586 research outputs found
Ivabradine: A new frontier in the treatment of stable coronary artery disease and chronic heart failure
No full textIvabradine (IVA) is an inhibitor of the If channel, the main determinant of the pacemaker function of the sinus node. This pure heart rate-lowering agent possesses well-documented antianginal and anti-ischemic properties comparable to well-established antianginal agents, such as β-blockers and calcium channel blockers. IVA lowers heart rate (HR) without affecting contractility or vascular tone and it is licensed for HR control in chronic heart diseases. The heart rate reduction is beneficial in patients with coronary artery disease (CAD), chronic stable angina pectoris, and chronic heart failure (CHF). Published trials documented not only pharmacodynamic and pharmacokinetic properties but also acceptable tolerance and safety profile of IVA, compared to other currently used cardiovascular drugs, including betablockers. The aim of this review is to describe recent evidences with IVA an interesting medicament, able to lower HR by selective inhibition of the If current, and to describe its applications
Ivabradine: beyond heart rate control.
No full textChronic stable angina pectoris (CSAP) usually occurs in patients with coronary artery disease (CAD) that affects one or more large epicardial arteries. It results when myocardial perfusion is insufficient to meet cardiac metabolic demand. Elevated heart rate (HR) is an important factor in the development of myocardial ischemia and angina pectoris. The pharmacologic agents most commonly administered in the treatment of CSAP are beta-blockers and calcium channel blockers (CCBs). However, the use of beta-blockers is limited by poor compliance related to contraindications and comorbidities, especially in elderly patients. Ivabradine is a new selective HR-lowering agent that selectively inhibits the pacemaker current I (f) in the sinus atrial node. In several randomized controlled trials, ivabradine 5-10 mg twice daily has demonstrated equivalent anti-ischemic and anti-anginal activity to beta-blockers and CCBs, with a good safety and tolerability profile. Although ivabradine has been shown not to improve cardiac outcomes in patients with stable CAD and left ventricular systolic dysfunction, it may be used to reduce the incidence of CAD outcomes in a subgroup of patients with HR a parts per thousand yen70 bpm. The aim of this short review is to summarize the use of ivabradine in the treatment of CSAP, and its potential utility in atherosclerosis, primitive and dilatative cardiomyopathy, and arrhythmias, such as postural tachycardia syndrome and inappropriate sinus tachycardia, where exclusive lowering of elevated HR may prove beneficial
2. La Vergine in trono con bambino, l’arcangelo e le figure di santi dalla Cappella H9 di San Lorenzo fuori le mura
No full textscheda epigrafica in La pittura medievale a Roma 312-1431, Corpus e Atlante, IV vol., Riforma e Tradizione, a cura di S. Romano, Milano, Jaca Book, 200
7. Rilievi di Castel di Sangro
No full textscheda epigrafica in A. Cadei, Nicola da Guardiagrele. Un protagonista dell’autunno del Medioevo in Abruzzo, Cinisello Balsamo (MI), Silvana editoriale, 200
"Children’s Effortful Control and Socio-Emotional adjustment "
No full textThe goal of this study is to examine the associations between children’s Effortful Control and their socio-emotional learning on a sample of italian elementary school children. The following socio-emotional skills were considered (CASEL, 2023): Self-Awareness, Self-Management, Social-Awareness, Relationship Skills, and Responsible Decision Making.
Previous studies have proved the relevance of Effortful Control for the development and mastering of effective emotion and behavior regulation strategies, which in turn are of paramount importance for appropriate social functioning (e.g., Eisenberg et al., 2001; 2010).
Participants include 38 children (57% females; mean age = 9.18, S.D. = 0.80), their parents (N = 29; 82% mothers) and their teachers from an elementary school in Rome.
After collecting consent forms from parents and teachers, the children were exposed to a intervention aimed at promoting Socio-Emotional Learning (SEL) with on-line sessions, in small groups, facilitated by a virtual robot (Gordon et al., 2023; Riccioni et al., 2023). The sessions were created following the guidance of previous validated programs aimed at promoting children’s SEL-related competences (e.g., CASEL, 2017; Caprara et al. 2014, 2015; 2020; Kendall et al., 2002). A battery of questionnaires was administered to all the participants at pre- and post-test. The questionnaires assessed the five SEL competencies (Elliott et al., 2020) and children’s Effortful Control (Simonds & Rothbart, 2004).
Preliminary repeated measure ANOVAs showed an overall improvement of children’s SEL skills.
Weak or not significant associations emerged for the SEL-related skills across informants.
Effortful Control was associated with Self-Management across informants.
No significant correlation emerged between Effortful Control and Social Awareness across informants, except for a moderate positive correlation for parent-reports.
Effortful Control was correlated only with child- and parent-reported Relationship Skills, and with Responsible Decision-Making across informants.
The present study contributes to the identification of individual variability in children’s SEL, and the results presented may be useful in gaining understanding on the individual mechanisms of children involved in intervention programs aimed at promoting well-being, in order to better understand who can benefit more from them. Moreover, the present study contributes to provide information about the correlation between children’s Effortful Control and SEL skills within a specific Socio-Emotional competencies framework, i.e., CASEL’s.
Given the plenty of Socio-Emotional dimensions identified (e.g., Cefai et al., 2018), embedding the analysis within a specific framework may provide more clarity and make replication easier
3. Ostensiorio di Atessa
No full textscheda epigrafica in A. Cadei, Nicola da Guardiagrele. Un protagonista dell’autunno del Medioevo in Abruzzo, Cinisello Balsamo (MI), Silvana editoriale, 200
37. I frammenti della decorazione affrescata di San Marcello al Corso, 37a. La decorazione dell’abside settentrionale e delle pareti adiacenti
No full textscheda epigrafica in La pittura medievale a Roma 312-1431, Corpus e Atlante, IV vol., Riforma e Tradizione, a cura di S. Romano, Milano, Jaca Book, 200
3. Ostensiorio di Atessa
No full textscheda epigrafica in A. Cadei, Nicola da Guardiagrele. Un protagonista dell’autunno del Medioevo in Abruzzo, Cinisello Balsamo (MI), Silvana editoriale, 200
Chartae Latinae Antiquiores. Facsimile edition of the Latin charters 2nd series ninth century. Part L, Italy XXII, Cava dei Tirreni, ed. by G. Cavallo e G. Nicolaj, Dietikon-Zurich 1997
No full text- …
