272 research outputs found
INTEND AND VIBRATION ANALYSIS OF G+10 RC BUILDING WITH BASE ISOLATION METHOD
No full textToday's efforts to explore the insulating performance of the base of lead rubber bearings in standard construction and construction benefit from a study of the same standard and separate structure, designed in one of the highest seismic zones in India. Modeling for both the repaired base and the separate base structure is handled in a limited component of the stored structure (G + 10). LRB measurements are determined by using STADD PRO, which is also validated by using a Visual Basic (VB) script. The results of critical specimens consisting of variant in ground contrast, floor drift, floor cutting and precise investment in the separate structure are evaluated. Using the base insulation system at the base of the floor structure (G + 8), it was discovered that the structure was better protected; the theory that isolating the base was a perfect tool for tires over 6-7 floors. The optimal variation of the version is found to be essentially separated. Similarly, the floor of the floor and the floor were also detected at the minimum when it came to a structure separated from the base. Assessing earthquake movements on a web site is one of the most critical stages of a seismic pattern, as well as adjusting the frame. In the timeless techniques used in architectural assessment, it is assumed that movement in the degree of frame structure is equivalent to the movement of the complementary area of the earth. This assumption is suitable only for tires or very solid rocks. For soft-based frameworks, structure activity generally differs from complementary area activity, as well as the induction element activated by adaptability to assist in the direct activity of the structure that is included
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Vascular Biotransport Considerations in Signaling Cascades
No full textThe vasculature of our body sensitively responds to varied biomolecules. These biomolecules are critical in triggering downstream protein synthesis, mRNA transcription, and DNA synthesis, and hence vascular homeostasis. We take these studies as an opportunity to understand the orchestra of (1) charge properties, (2) mechanical topography, (3) fluid dynamics, and (4) molecular cues to obtain a systemic and integrative understanding of the vasculature. In this work, we introduce a novel in-situ streaming potential device to quantify the electrostatic contribution of morphological changes in confluent endothelial cells (ECs). We further study the effect of mechanical topographies of nan-patterned titanium on ECs. Both species mass transfer and mechanotransduction have been suggested as the underlying mechanisms for activating ECs. However, in recent years, the dominance of mechanotransduction at the endothelium has been qualitatively demonstrated through in-vitro experiments attempting to emulate the vasculature. Thus, it remains plausible that biomolecular mass transfer may be significant in vascular signaling pathways. This work shows that a more cautious analysis that delineates endothelial mechanotransduction from mass transfer remains warranted. Having said that, we propose a novel, in-vitro experimental methodology using membrane separations technology. The methodology is flexible and robust, in that it can be used with mass transfer-limited and reaction-limited processes and can address a number of controllable scenarios. Finally, we characterize the endothelial behavior in healthy and diseased ECs by characterizing the sub-endothelium and the underlying endothelial signaling pathways. The work presented here demonstrates the vast number of biotransport factors to be captured while studying the fascinating vascular endothelium. Understanding the mechanistic factors of ECs and the triggered signaling pathways is crucial to our search for novel therapeutics. Keywords - vaculature, charge, mechanical, mass transfer, mechanotransduction, signalin
Evaluation of Buccal Bone Penetrating Property of 4% Articaine with 1:100,000 Adrenaline Versus 2% Lignocaine with 1:80,000 Adrenaline Classic Inferior Alveolar Nerve Block Technique in Adult Patients undergoing Erupted Mandibular Molar Teeth Extraction
No full textSUMMARY AND CONCLUSION:
A classic inferior alveolar nerve block technique is technique sensitive with high failure rates 24 and complications when compared to a buccal and lingual infiltration (field block technique) 18,19. Due to the thick cortical buccal plate 2% Lignocaine 1:80,000 adrenaline cannot penetrate the bone and anesthetize the adult mandibular molar teeth. Hence for a single mandibular molar tooth extraction Inferior alveolar nerve block is inevitable .But 4% Articaine 1:100,000 adrenaline has been advantageous for the surgeon which anesthetizes the mandibular molar tooth adequately only by buccal and lingual infiltration and allows to complete the tooth extraction procedure successfuly thereby avoiding many complications of Inferior alveolar nerve block. This study recommends the use of 4% Articaine with 1:100,000 adrenaline to be given as buccal and lingual infiltration in adult patients undergoing erupted mandibular molar teeth extraction. However, further studies are needed to estimate the onset, duration of anesthesia and their use in cases of irreversible pulpitis in case of erupted mandibular teeth extraction in adults
Role of G-protein Coupled Receptor Kinase Interacting Protein 1 (GIT1) in Bone Homeostasis and Brain Development
No full textThesis (Ph.D.)--University of Rochester. School of Medicine and Dentistry. Dept. of Biomedical Genetics, 2009.G-protein coupled receptor kinase interacting protein-1 (GIT1) was identified as a 97-kd protein tyrosine phosphorylated by c-Src upon angiotension II (Ang II) stimulation in vascular smooth muscle cells (VSMC). GIT1 plays a key role in cytoskeleton dynamics, membrane trafficking and in recycling endosomes. Since GIT1 regulates cytoskeleton dynamics, we hypothesized that, deletion of GIT1 might perturb osteoclast function and bone remodeling homeostasis. Bone morphometric analyses show that GIT1 KO mice have a 2.3 fold increase in bone density compared to WT controls. Osteoclasts cultured from bone marrow cells of GIT1 KO were not able to form podosome belts at the cell periphery resulting in decreased bone resorbtion and impaired osteoclast function in comparison to WT. Furthermore we demonstrate that GIT1 is tyrosine phosphorylated upon RANK stimulation, interacts with RANK receptor and is required for PLC2 phosphorylation in osteoclasts. Thus we demonstrate that GIT1 regulates bone density in vivo through effects on RANK- PLC2 required for podosome belt formation in osteoclasts.
GIT1 is highly expressed in the brain. In vitro data have shown it to be important for spine( actin rich protrusiosn) and synapse formation in the brain. These processes are dependent on actin cytoskeleton organization. Hence we hypothesized that deletion of GIT1 might affect these process, which are known to be important for learning and memory. GIT1 KO mice showed markedly reduced dendritic length and spine density in the hippocampus by 36.7 % and 35.1% respectively. This correlated with their poor adaptation to new environments as shown by impaired performance on tasks dependent on learning. We also studied the effect of GIT1 gene deletion on brain microcirculation. In contrast to findings in systemic circulation, GIT1 KO mice had an intact blood-brain barrier and normal regional cerebral blood flow as determined with radiotracers. Thus, our data suggest that GIT1 plays an important role in brain in vivo by regulating spine density involved in synaptic plasticity that is required for processes involved in learning.
In conclusion, we show novel roles of GIT1, a multi-domain scaffold protein in bone homeostasis and for cognition in the brain by regulating process dependent on actin cytoskeleton dynamics
Set Theoretic Rajan Transform and its Properties
No full textIn this paper we describe the formulation of a novel transform called Set Theoretic Rajan Transform STRT which is an extension of Rajan Transform RT RT is a coding morphism by which a number sequence integer rational real or complex of length equal to any power of two is transformed into a highly correlated number sequence of same length STRT was introduced by G Sathya In STRT RT is applied to a sequence of sets instead of sequences of numbers Here the union U is analogous to addition operation and symmetric difference is analogous to subtraction - This transform satisfies some interesting set theoretic properties like Cyclic Shift Invariance Dyadic Shift invariance Graphical Inverse Invariance This paper explains in detail about STRT and all of its set theoretic propertie
The cyber pandemic: exploring the financial sextortion of young males
No full textAs the world grappled with Covid-19, another epidemic emerged in the cyber world in the form of financial sextortion. This organized crime lures and entraps victims who are primarily teenage males and young men. This exploratory study examines the growing trend of male sextortion in the past couple of years through the lens of Cyber Lifestyles-Routine Activities Theory (CLRAT) and the Modus Operandi (MO) of sextortionists. Using a semi-systematic literature review, this study investigates victimization through the key elements of CLRAT: exposure & proximity, target attractivity, and guardianship. There is also an examination of MO in both the possession and extortion stages, as a way to understand offending behaviours. The findings highlight how the interplay between CLRAT & MO explains the susceptibility of young males to victimization. This new wave of sextortion lures young males primarily for financial gains compared to conventional victims who are females targeted through sexual motives. The study explores the existing minor & gendered-focus lens on sextortion, calling attention to the unique challenges financial sextortion poses from a legal perspective, for law enforcement, and for victim services
Regularization of Highly Ill-Conditioned RBF Asymmetric Collocation Systems in Fractional Models
No full textModeling and Simulation of Genome Evolution Using Linear Boolean Functions Associated with One Dimensional Cellular Automata
No full textStructural and functional behavior of genomes could be studied using one dimensional binaryvalued three neighborhood cellular automata updating rules These updating rules are linear Boolean functions and they are applied to the adjoint sequences of adenine A Thymine T Guanine G and Cytosine C corresponding to the characteristic sequence of a genome This paper proposes the use of linear Boolean functions and demonstrates the textural or fractal behavior of genome evolution in terms of nucleotide adjoint
Localization and quantification of ductal carcinoma in the calcified regions of gamma corrected mammographic images
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