245 research outputs found
Reductions in viral load and increases in T lymphocyte numbers in treatment-naive patients with advanced HIV-1 infection treated with ritonavir, zidovudine and zalcitabine triple therapy.
No full textWeek 48 safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced participants (BRIGHTE study)
No full textAlle nostre città servono buoni medici
No full textFriedrich Engels aveva ventiquattro anni quando iniziò a scrivere La Situazione della classe operaia in Inghilterra (1845). Engels arrivò in Inghilterra nell’autunno del 1842 per rimanervi per la maggior parte dei due anni che seguirono. La sua opera vide la luce nella sua forma definitiva solo nell’estate del 1845 con una prefazione e una dedica rivolta alla classe operaia della Gran Bretagna. La prima pubblicazione in inglese del testo sarà quella americana del 1877, ristampata poi a Londra nel 1892. In Italia l’opera di Engels arriverà nel 1889 grazie all’editore Mongini, per poi essere ri- stampata dalla casa editrice Avanti a Milano nel 1914.
La misère du monde (1993) di Pierre Bourdieu verrà tradotta per la prima volta in italiano nel 2015 grazie al lavoro di cura di Antonello Petrillo e Ciro Tarantino. Negli anni Novanta, per realiz- zare la sua opera, il sociologo francese volle costruire una squadra di ricerca composita di cui facevano parte Sayad, Champagne, Wacquant, Bourgoise, Balazs, Lenoir, Christin, Pialoux, Beaud, Garcia, Pinto, Broccolichi, Euvrard, Accardo, Soulié, E. Bourdieu e Faguer. La traduzione italiana sarà realizzata sul testo della prima edi- zione francese in conformità a quanto disposto dal sociologo, al fine di essere il più fedele possibile al linguaggio parlato, così come gli autori delle interviste si erano sforzati di esserlo al momento del- la loro trascrizione
Evaluation of a computer algorithm for promoting both annual hepatitis C screening and hepatitis B vaccination among HIV-infected individuals (ORCHESTRA programme)
No full textFostemsavir in adults with multidrug-resistant HIV-1 infection
No full textAmong some patients with human immunodeficiency virus type 1 (HIV-1) infection who have undergone multiple antiretroviral therapies and have limited options for treatment, new classes of antiretroviral drugs with novel mechanisms of action are needed. Fostemsavir is the prodrug of temsavir, a first-in-class investigational HIV-1 attachment inhibitor. METHODS In this ongoing phase 3 trial in 23 countries, we enrolled patients with multidrug-resistant HIV-1 infection in two cohorts, according to their remaining treatment options. In the first cohort, we assigned (in a 3:1 ratio) patients who had the option of using at least one fully active, approved antiretroviral drug in at least one but no more than two antiretroviral classes to add either fostemsavir (at a dose of 600 mg twice daily) or placebo to their failing regimen for 8 days, followed by open-label fostemsavir plus optimized background therapy (randomized cohort). In the second cohort, patients who had no remaining antiretroviral options were started on open-label fostemsavir plus optimized background therapy on day 1 (nonrandomized cohort). The primary end point was the mean change in the HIV-1 RNA level from day 1 through day 8 in the randomized cohort. RESULTS A total of 371 patients were treated, including 272 in the randomized cohort and 99 in the nonrandomized cohort. At day 8, the mean decrease in the HIV-1 RNA level was 0.79 log10 copies per milliliter in the fostemsavir group and 0.17 log10 copies in the placebo group (P<0.001). At week 48, a virologic response (HIV-1 RNA level, <40 copies per milliliter) had occurred in 54% of the patients in the randomized cohort and in 38% of those in the nonrandomized cohort; the mean increase in the CD4+ T-cell count was 139 cells per cubic millimeter and 64 cells per cubic millimeter, respectively. Adverse events led to the discontinuation of fostemsavir in 7% of the patients. In the randomized cohort, glycoprotein 120 (gp120) substitutions were found in 20 of 47 patients (43%) with virologic failure. CONCLUSIONS In patients with multidrug-resistant HIV-1 infection with limited therapy options, those who received fostemsavir had a significantly greater decrease in the HIV-1 RNA level than those who received placebo during the first 8 days. Efficacy was sustained through 48 weeks
Méthodes d'entrainement modernes chez les footballeurs professionnels : l'utilisation des jeux réduits
No full textL'intégration de jeux réduits au cours des séances d'entrainements de football assure la possibilité d'optimiser le contact avec les joueurs, d'augmenter l'efficacité des exercices et de réduire la durée totale d'entraînement grâce aux caractéristiques multi-factorielles de ces type d'efforts tactique, technique et physique (Dellal et al., 2008; Owen et al., 2004). Les jeux réduits ont été démontré comme des outils intéressant de motivation intrinsèque comparativement à un autre type d'entrainement générique ou d'autres formes d'exercices (course continue, interval-training) à charge de travail équivalente (Hill-Haas et al., 2009). Cette méthode d'entrainement est particulièrement bénéfique pour les joueurs de haut niveau qui ont un temps d'entrainement limité et ayant un grand nombre de période intenses. En partant de ces constats, l'objectif de cette thèse est d'apporter une revue de littérature complète sur l'utilisation des jeux réduits afin de cibler précisément leurs impacts physique, physiologique, technique et tactique sur des joueurs d'un niveau professionnel. Après avoir démontré et relevé l'importance du développement de la composante « technico-physique » à haut niveau, le premier objectif de cette thèse consiste à comparer s'il existe des différences technique, physique et physiologique selon les variations de surfaces de jeux utilisées (ARTICLE I). Après avoir comparé qu'il y avait bien des ressemblances mais également de forte différence selon les ratios par joueur utilisé (en mètre carré par joueur), nous avons analysé les différences tactique, physiques et techniques exactes lors de jeux à surfaces très réduites, moyennement réduites et des jeux à dimensions proche des conditions de matchs (SSGs vs. MSGs vs. LSGs, ARTICLE II). Les résultats de ces deux protocoles expérimentaux ont permis de fournir une trame permettant de mieux appréhender l'intégration des jeux réduits au sein de l'entraînement en la considérant comme un outil « intégré » de travail athlétique, notamment chez le footballeur professionnel. L'ARTICLE III a testé les effets de l'utilisation de SSG en démontrant qu'il est un outil de développement des performances athlétiques. En conclusion, bien que l'intérêt de l'utilisation des jeux réduits comme une forme de travail développant les qualités technicotactico- athlétiques » ait bien été démontré au sein de ce travail de thèse, l'auteur souligne le fait que les coaches doivent être très attentif dans la préparation, l'organisation, la planification et la mise en place des jeux réduits afin d'obtenir les résultats souhaités en relation avec les besoins du football moderneIntegrating the use of SSGs as part of the technical coaching programs within soccer training, ensures coaches have the opportunity to maximize their contact time with players, increase the efficiency of training and subsequently reduce the total training time due to their multifunctional nature (Dellal et al., 2008; Owen et al., 2004). SSGs have also been suggested to increase player motivation to train when compared to generic running intervals eliciting the same intrinsic loading (Hill-Haas et al., 2009). It is believed that this type of training is particularly beneficial for those elite players whom have limited training time as a result of intense fixture periods. In this context, the intention of this thesis is to draw from current literature in order to establish the key physical, physiological, technical and tactical demands imposed upon players at the elite professional level of the game. Having outlined and linked these specific demands and in turn highlighted key physical-technical components needed for physical performance development at the elite level, the primary aim of the thesis is to further develop the literature through identifying whether or not there are similar physiological and technical demands when comparing small vs. larger sided training games (Paper I). Having established if a link between the two game types exist, the literature will be progressed through the examination of SSGs, MSG and LSGs in order to evaluate the reliability and variation levels in physical and technical activities between these game formats (Paper II). Findings from the initial investigations within this thesis will be used to provide a framework for the use of more functional training (SSGs) as part of a training intervention aimed at improving physical performance in elite level players (Paper III). Finally, based on the findings of the studies within this thesis, the author will attempt to highlight the need for careful preparation, advanced planning and the successful implementation of SSGs to supplement the day to day training of modern day professional soccer player
Association between serum cytokine profiles and schistosomiasis-related hepatic fibrosis: Infection by Schistosoma japonicum versus S-mansoni
No full textDevouring the town and its fritter. The peripheries and the left-wing identity politics
No full textServing as the starting point for this article, Didier Eribon’s Returning to Reims reveals the personal and psychological costs suffered by a person who abandons the folk class they were born into and makes it to the upper class. It is a significant issue for many intellectuals, particularly those who, like Eribon, are inclined towards left-wing views. Not only are they lodged in their non-places but they also lose the possibility to contact their loved ones among whom they feel like strangers. Acknowledging Eribon’s path, anyone who advances socially abandons their class and, like Eribon, sometimes feels repulsed by it. The author of the article tries to show that Eribon’s experience should not be universalised and that other identity strategies are possible to enable both the family ties and the advancement of the political and social project. Based on Returning to Reims and Retour sur la condition ouvrière by Stéphane Beaud and Michel Pialoux, the left-wing vision appears to be split into what constitutes a communal-conservative project and a liberal-individual project. If the left wing is to be effective, it needs to be fused together. The folk class is not as conservative as it seems, and it is not for conservative reasons that it tends to vote for right-wing parties
Chikungunya Fever: A Killer Epidemic in Ahmedabad City, India
No full textBackground The Chikungunya virus is an alphavirus native to tropical Africa and Asia and is transmitted to humans by the bite of infected Aedes mosquitoes. The symptoms of Chikungunya include sudden onset of fever, severe arthralgia, and maculopapular rash. Thirty percent of the population on the French R�union Island was afflicted with Chikungunya in the past year. They reported 237 deaths. India on the other hand reported 1.39 million cases of Chikungunya but no deaths. Methods Mortality data from 2002-2006 was obtained from the Ahmedabad Municipal Corporation (AMC). Actual mortality rate of 2006 was compared to the mortality rate of 2002-05 and its statistical significance tests were carried out. Findings Mortality data obtained from the Ahmedabad Municipal Corporation (AMC) suggests that 3112 excess deaths occurred in August-November (epidemic period) compared to the average deaths in the same months during the previous four years. These differences in deaths were found to be highly statistically significant. A peak in excess mortality is seen in the month of September when 1489 additional deaths were recorded. Case fatality rates for Ahmedabad also turn out to be much higher than that of the Reunion Island. Interpretation The Chikungunya epidemic was raging when the excess deaths occurred. There were no other adverse events or other epidemics that took place could explain this excess mortality. Government authorities, WHO and other international public health agencies should take these findings of excess mortality seriously and investigate into this occurrence of excess deaths to understand this reemerging disease and prevent future epidemics and mortality.
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