2,597 research outputs found

    La tomba del Tifone: effetti speciali etruschi

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    Gli autori esaminano la Tomba del Tifone di Tarquinia da tre diversi punti di vista archeologici: architettura e impaginato (G. Bagnasco Gianni); pittura tombale (M. Marzullo); scelte iconografiche legate a creature mostruose (L. Perego

    Device for mHealth

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    Nowadays, wearable technology is the most promising and market growing technology. Wearable can be considered the winning card up to the mHealth sleeve. Despite mHealth born around the 2000s, only in the last lustrum, it has seen a massive diffusion both for monitoring and diagnosis. Moreover, many existing devices and products have been equipped with data transmission technologies in order to improve the capability of communicating data over the Internet by means of mobile devices (smartphone or tablet) or direct connection. Data transmission allow for communicating health data directly to physicians. This permits to monitor the patient from a distance directly from home, increasing their life quality and, in the meantime, decreasing the welfare costs. This chapter wants to be a compendium of the existing solution in term of wearable, but also non-wearable devices for mobile health. The last paragraph of the chapter reports current and future development of wearable devices, with invisible technology, smart garments, and Wearable 2.0

    Humour and audiovisual translation: An overview

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    The paper offers a brief overview of the history of audiovisual translation with a focus on humour and the difficulties implied in translating it

    SN1-XFEXOY - A NEW MATERIAL WITH HIGH-CARBON MONOXIDE SENSITIVITY

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    The preparation method and the sensing properties (sensitivity and selectivity to interfering gases) towards carbon monoxide of the new ternary compound Sn1-xFexOy, deposited in the form of thin films, are presented in this paper. The metal of the VIIIB group is introduced with concentrations in the range 0<x<25 at. %. Thin films are sputtered using the RGTO (rheotaxial growth and thermal oxidation) technique. This technique consists of metal deposition onto a substrate maintained at a temperature higher than the metal melting point and metal oxidation by means of an annealing cycle in pure oxygen. Particular emphasis is given to the relations between some preparation parameters of the material, namely the atomic percentage of iron or the annealing cycle, and to the sensor sensitivity towards CO and other interfering gases like C2H5OH, H-2 and NOx diluted in dry air. A sensitivity S=(C-gas-G(air))/G(air)=3.5 towards 10 ppm of CO has been measured: the kinetic characteristics of the sensors are also presented, together with the working mechanism

    Kobayashi--Hitchin correspondence for twisted vector bundles

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    We prove the Kobayashi--Hitchin correspondence and the approximate Kobayashi--Hitchin correspondence for twisted holomorphic vector bundles on compact Kähler manifolds. More precisely, if X is a compact manifold and g is a Gauduchon metric on X, a twisted holomorphic vector bundle on X is g−polystable if and only if it is g−Hermite-Einstein, and if X is a compact Kähler manifold and g is a Kähler metric on X, then a twisted holomorphic vector bundle on X is g−semistable if and only if it is approximate g−Hermite-Einstein

    Molecular cloning and tissue-specific expression of the mouse homolog of the rat brain 14-3-3 theta protein: characterization of its cellular and developmental pattern of expression in the male germ line

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    The highly conserved 14-3-3 family of proteins, originally reported as brain-specific and then found in various somatic cells and oocytes, interacts with several important signal transduction kinases so that actually the 14-3-3 proteins ave considered as modulators of multiple signal transduction pathways. Here we show that a 14-3-3 protein is also expressed in the male germ cells, thus extending the protein cellular distribution to a cell line never reported to express 14-3-3 proteins. Screening of a mouse spermatogenic cells lambda gt11 cDNA library with affinity-purified polyclonal antibodies to the tyrosine kinase SP42 allowed the isolation of several positive clones. Sequencing of a positive cDNA clone revealed a 735-nucleotide open reading frame encoding a protein of 245 amino acids (27,778 Da). The predicted protein was found to be identical to the most recently discovered 14-3-3 isoform, the theta subtype from a rat brain. Here we demonstrate that 14-3-3 theta mRNA is highly expressed in testis and brain only. Western immunoblot analyses confirm the Northern blot data. Developmental Northern and Western blot analyses are consistent with an expression and translation of the 14-3-3 theta gene throughout spermatogenesis. However, analysis of RNA from purified populations of spermatogenic cells at different developmental stages and immunohistochemistry on adult testis sections reveal that within the testis the 14-3-3 theta gene products are most abundant in meiotic prophase spermatocytes, and, above all, in differentiating spermatids. Both testicular and epididymal spermatozoa are negative. The present study is the first report on the presence and molecular characterization of the 14-3-3 theta gene product in the male germ line. Our observations suggest that this specific member of the 14-3-3 protein family could play distinct modulatory roles in the complex development of the mammalian male germ cell lineage

    Selective mass scaling for distorted solid-shell elements in explicit dynamics: optimal scaling factor and stable time step estimate

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    The use of solid-shell elements in explicit dynamics has been so far limited by the small critical time step resulting from the small thickness of these elements in comparison with the in-plane dimensions. To reduce the element highest eigenfrequency in inertia dominated problems, the selective mass scaling approach previously proposed in [G. Cocchetti, M. Pagani and U. Perego, Comp. \& Struct. 2013; 127:39-52.] for parallelepiped elements is here reformulated for distorted solid-shell elements. The two following objectives are achieved: the critical time step is governed by the smallest element in-plane dimension and not anymore by the thickness; the mass matrix remains diagonal after the selective mass scaling. The proposed approach makes reference to one Gauss point, trilinear brick element, for which the maximum eigenfrequency can be computed analytically. For this element, it is shown that the proposed mass scaling can be interpreted as a geometric thickness scaling, obtaining in this way a simple criterion for the definition of the optimal mass scaling factor. A strategy for the effective computation of the element maximum eigenfrequency is also proposed. The considered mass scaling preserves the element translational inertia, while it modifies the rotational one, leading to errors in the kinetic energy when the motion rotational component is dominant. The error has been rigorously assessed for an individual element, and a simple formula for its estimate has been derived. Numerical tests, both in small and large displacements and rotations, using a state-of-the-art solid-shell element taken from the literature, confirm the effectiveness and accuracy of the proposed approach. Copyright {\copyright} 2014 John Wiley \& Sons, Ltd

    A four-season molecule : osteocalcin. Updates in its physiological roles

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    Osteocalcin (OC) is the main non-collagenous hydroxyapatite-binding protein synthesized by osteoblasts, odontoblasts, and hypertrophic chondrocytes. It has a regulatory role in mineralization and it is considered a marker of bone cell metabolism. Recent findings evidenced new extra-skeletal roles for OC, depicting it as a real hormone. OC shares many functional features with the common hormones, such as tissue-specific expression, circadian rhythm, and synthesis as a pre-pro-molecule. However, it has some peculiar features making it a unique molecule: OC exists in different forms based on the degree of carboxylation. Indeed, OC has three glutamic acid residues, in position 17, 21, and 24, which are subject to γ-carboxylation, through the action of a vitamin K-dependent γ-glutamyl carboxytransferase. The degree of carboxylation, and thus the negative charge density, determines the affinity for the calcium ions deposited in the extracellular matrix of the bone. The modulation of the carboxylation could, thus, represent the mechanism by which the body controls the circulating levels, and hence the hormonal function, of OC. There are evidences linking OC, and the bone metabolism, with a series of endocrine (glucose metabolism, energy metabolism, fertility) physiological (muscle activity) and pathological functions (ectopic calcification). Aim of this review is to give a full overview of the physiological roles of OC by collecting the newest experimental findings on this intriguing molecule
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