1,721,030 research outputs found
A new synthesis of 2-hydroxy-3-alkylcyclopent-2-en-1-ones.
No full textA synthesis of the title compound, based upon acid-catalyzed rearrangement of 2,3-epoxy-2-alkylcyclopentanones,readly obtainable by alkaline hydrogen peroxyde oxydation of the corresponding 2,alkylcyclopent-2-en-1-ones, is reported
An improved procedure for the preparation of β-nitroethylamines
No full textNitroethylene and α-nitrostyrene, generated in situ from 2-benzoyloxy-1-nitroethane and 2-benzoyloxy-1-nitro-1-phenylethane respectively, reacted with aliphatic amines to give the corresponding Michael adducts in near quantitative yield
A new preparation of sulfonyl chlorides via pyridinium sulfonates
No full textThis communication describes the reaction of pyridinium sulfonates with phosphorous pentachloride or thionyl chloride which presents a new preparation of sulfonyl chloride
Recent advances in the stereoselective synthesis of trans-3,4- disubstituted-piperidines: applications to (-)paroxetine
No full textPiperidine ring systems are the key structural elements in a vast array of natural products as well as in a large class of biologically
active natural products, being also often embedded within scaffolds recognized as privileged structures by medicinal chemists.
Accordingly, new stereoselective routes to substituted piperidines are of widespread interest. An overview of the asymmetric synthetic
routes to trans-3,4-disubstituted piperidines, featuring the substitution pattern of ( )-paroxetine [(3S,4R)-4-(4-fluorophenyl)-3-(3,4-
methylenedioxyphenoxymethyl)piperidine], a well-known selective serotonin reuptake inhibitor (SSRI) used worldwide as an antidepressant
in humans, is presented. This review is mainly focused on the enantioselective routes to ( )-paroxetine, which has become a very
popular synthetic target to test the efficiency of new methodologies. Some recent stereoselective approaches to the racemic compound are
also included
The use of phase-transfer catalysis for the ZV-alkylation of indole
No full textThe indole is exclusively N-alkylated in good yield by transfercatalysi
A new elegant route to a key intermediate for the synthesis of 9(O)-methanoprostacyclin
No full textA novel synthesis of functionalyzed bicyclo[3,3,0]octane,anadvanced intemediate for the synthesis of carbaprostacyclin, is reported
Enantioselective formal synthesis of Acromelic acid A via tandem Michael reaction methodoligy
No full textA new formal synthesis of the potent neurotoxin,Acromelic acid A, has been accomplished by a tandem Michael reaction involving a 2-nitro-1,3-diene incorporated into a dihydropyridone nucleus as electrophilic alkene and an unsaturated glutamic ester derivative prepared from D-serine as a tool for the stereoselective construction of the 2,3,4-trisubstitued pyrrolidine ring sistem
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