199 research outputs found
Il glossario TECT: uno strumento lessicale per la schedatura della pittura parietale
No full textl volume raccoglie i contributi della Giornata di studio tenutasi a Padova il 20 marzo 2014 dal titolo "La pittura frammentaria di età romana. Metodi di catalogazione e studio dei reperti", organizzata con l'obiettivo prioritario di presentare ad un pubblico di specialisti le prime fasi del progetto TECT, il cui nome deriva dall'abbreviazione del termine latino tectorium (intonaco), sviluppato al fine di creare una banca dati delle pitture parietali di età romana rinvenute in Italia settentrionale.
La "filosofia" del database TECT viene esplicitata nel volume, non solo tramite la presentazione della scheda, ideata nell'ambito del progetto con lo scopo di sistematizzare le evidenze archeologiche (A. Didonè, G. Salvo), ma anche attraverso la proposta di un glossario - pensato per uniformare la descrizione delle testimonianze pittoriche e per facilitarne la ricerca - le cui fasi di elaborazione vengono illustrate in questi atti (R. Helg, A. Malgieri)
Modeling and Representing Conceptual Change in the Learning of Successive Theories: The Case of the Classical-Quantum Transition
No full textMost educational literature on conceptual change concerns the process by which introductory students acquire scientific knowledge. However, with modern developments in science and technology, the social significance of learning successive theories is steadily increasing, thus opening new areas of interest to discipline-based education research, e.g., quantum logic, quantum information, and communication. Here, we present an initial proposal for modeling the transition from the understanding of a theory to the understanding of its successor and explore its generative potential by applying it to a concrete case—the classical-quantum transition in physics. In pursue of such task, we make coordinated use of contributions from research not only on conceptual change in education, but also on the history and philosophy of science, on the teaching and learning of quantum mechanics, and on mathematics education. By means of analytical instruments developed for characterizing conceptual trajectories at different representational levels, we review empirical literature in the search for the connections between theory change and cognitive demands. The analysis shows a rich landscape of changes and new challenges that are absent in the traditionally considered cases of conceptual change. In order to fully disclose the educational potential of the analysis, we visualize categorical changes by means of dynamic frames, identifying recognizable patterns that answer to students’ need of comparability between the older and the new paradigm. Finally, we show how the frame representation can be used to suggest pattern-dependent strategies to promote the understanding of the new content, and may work as a guide to curricular design
The clearance of misfolded proteins in neurodegenerative diseases by zinc metalloproteases: An inorganic perspective
No full textIn recent years there has been a wide interest toward zinc metalloproteases involved in neurodegenerative diseases. Enzymes such as matrix metalloproteases, neprilysin, insulin degrading enzyme, etc. play a pivotal role in the homeostasis of peptides and proteins whose accumulation and fibrillation seem to be the major cause for the development of such diseases. It is also well known that chemical factors such as oxidative stress, small molecules and metal ions are able to significantly affect the activity of the above mentioned metalloproteases and therefore, very recently, many research groups have been focused on studying the interaction between those chemical factors and some of the enzymes involved in neurodegenerative diseases. Particularly, metal ions can play various roles (catalytic, structural, allosteric) in enzymes and both the coordination environment as well as the specific metal ion involved, determine the particular function of a metalloprotease.In this article, chemical factors which modulate the activity of zinc metalloproteases involved in neurodegenerative diseases are examined together with recently proposed therapeutic routes related to them. Moreover, two of the most used experimental techniques applied for studying such modulation are also reviewed. © 2013 Elsevier B.V
Editorial. The democracy of emergency at the time of the coronavirus: the virtues of privacy.
No full textApproximate time–energy uncertainty relationship from the fixed-energy sum over paths approach
No full textIn this article, we show how an approximate time–energy uncertainty relationship of the form ΔEΔt ≃ ћ can be derived in the context of the fixed-energy sum over paths approach to quantum bound systems. The relationship connects the indeterminacy Δt on the travel time of the quantum object to the width ΔE of the resonance in the approximate Green function corresponding to an allowed value of energy. The mathematical origin of the relationship is to be tracked to the Fourier transform relationship between the time propagator and energy-dependent Green function; however, the core of the derivation does not use advanced mathematics, may be carried out using mostly graphical and geometrical methods, and may provide insight to students on the meaning and origin of the time–energy uncertainty relationship. Our work may contribute to close a gap by which the time–energy relationship is most often taught with insufficient explanation at elementary level
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