1,720,974 research outputs found
Modeling ISFET microsensor and ISFET-based microsystems: a review
No full textSilicon technology is one of the most promising for sensor development. Moreover, electronic simulation tools, originally introduced to design electronic circuits, can be adapted to design silicon-based chemical- and bio-sensors. These considerations lead to the description of the models we developed and implemented in the program SPICE for simulating ion-sensitive field-effect transistors (ISFETs) and ISFET-based microsystems. The implementation in SPICE and the simulation results are described in terms of each model. In particular, a new model of a Si3N4-gate ISFET operating under subthreshold conditions and the related electrochemical characterization are presented.
The ISFET models were then used to develop a CAD system that can be considered as a general-purpose tool for designing integrated ISFET-based sensors and microsystems with on-chip processing and control capabilitie
Transduction mechanisms from biological membranes to silicon sensors : modelling and computer simulations
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Cultured neurons coupled to microelectrode arrays: Circuit models, simulations and experimental data
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A CAD System for Developing Chemical Sensor-Based Microsystems with an ISFET-CMOS Compatible Technology
No full textA CAD system, which makes use of an ad hoc technology [ISFET/CMNOS (ionsensitive field-effect transistor/complementary metal nitride-oxide semiconductor) technology] for fabricating ISFET-based microsystems, has been developed. This technology combines ISFET fabrication technology and CMOS IC processes. To test it, we designed and built a microsystem consisting of three blocks (sensor, amplifier, and test structures) which allows us to check the electrochemical characteristics of the ISFET-based sensor, to evaluate the response of the microsystem under different measurement conditions, and to extract the parameters for BIOSPICE. The extraction of electrical and chemical parameters necessary to simulate the sensor behavior and to optimize the circuit design represents the basic and fundamental link between design and manufacturing. The CAD system developed can be considered a general purpose tool for designing integrated and ` intelligent` sensing probes based on ISFET sensors. Similar microsystems can be used for any biomedical, environmental and biotechnological applications where slight variations around a static pH value are expected and miniaturization is require
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