110 research outputs found
A Novel Reactivity of -Nitro Ketone Tosylhydrazones with DBU. Synthesis of -Unsaturated Enone Tosylhydrazones
No full textSynthesis of alpha,beta-unsaturated carbonyl derivatives from 2-nitroketone
Discrete Time Variable Structure Control of Robotic Manipulators Based on Fully Tuned RBF Neural Networks
No full textThis paper presents a discrete-time variable structure control based on neural networks for a planar robotic manipulator. Radial basis function neural networks are used to learn about uncertainties affecting the system. The learning algorithm combines the growth criterion of the resource allocating network technique with an adaptive extended Kalman filter to update all network parameters. The analysis of the control stability is given and the controller is evaluated on the ERICC robot arm. Simulations show that the proposed controller produces good trajectory tracking performance and is robust in the presence of model inaccuracies
Minerali fibrosi anfibolici naturali e sintetici tra microstrutture fibrillari ed organizzazione molecolare. Un caleidoscopio bio-funzionale.
No full textDiscrete time sliding mode control of robotic manipulators: Development and experimental validation
No full textThis paper presents a robust discrete-time sliding mode control coupled with an uncertainty estimator designed for planar robotic manipulators. Experimental evidence shows satisfactory trajectory tracking performances and noticeable robustness in the presence of model inaccuracies, disturbances and payload perturbations. Ultimate boundedness of the tracking errors is proved, as well as boundedness of the estimation error with arbitrary precision
Electrons and phonons in the ternary alloy CaAl2-xSix as a function of composition
No full textWe report a detailed first-principles study of the structural, electronic, and vibrational properties of the superconducting C32 phase of the ternary alloy CaAl2?xSix, both in the experimental range 0.6x1.2, for which the alloy has been synthesized, and in the theoretical limits of high aluminum and high silicon concen- tration. Our results indicate that, in the experimental range, the dependence of the electronic bands on com- position is well described by a rigid-band model, which breaks down outside this range. Such a breakdown, in the theoretical limit of high aluminum concentration, is connected to the appearance of vibrational instabili- ties and results in important differences between CaAl2 and MgB2. Unlike MgB2, the interlayer band and the out-of-plane phonons play a major role on the stability and superconductivity of CaAlSi and related C32 intermetallic compounds
Paslahepevirus balyani in Suidae coming from the Monti Sibillini National Park (2020-2024)
No full textPaslahepevirus balayani or hepatitis E virus (HEV) represents one the most diffused viral zoonotic foodborne pathogens in Europe, and genotype 3 results one of the most identified in Italy among Suidae. For this reason, the aim of this work was to carry out biomolecular and phylogenetic evaluations of the persistence and evolution of HEV-3 in wild boars (Sus scrofa) and domestic swines (Sus scrofa domesticus) from the Monti Sibillini National Park (Ascoli Piceno province) in the period between 2020 and 2024. More in detail, from December 2020 to January 2024, the sampling of n. 1054 Suidae was performed and two aliquots (15±2 g) of tissue were taken from each of them: one from the liver and one from muscle tissue (diaphragm pillar) obtained by plucks conferred at the slaughterhouse level in Ascoli Piceno (EU Reg. No. 624/2019, No. 625/2017, and R.L. Marche No. 13/2012). In the tested population, 818/1054 (77.61%) were wild boars and 236/1054 (22.39%) were domestic pigs raised with extensive methods for domestic consumption. Tissues followed the same standardized laboratory procedures: homogenization, RNA extraction by the Trizol LS method, and finally biomolecular tests: real time RT-qPCR and nested RT-PCR of the codifying regions ORF-1, ORF-2, and ORF-3 of HEV. Sequencing of the positive ones was followed by: nucleotide similarity, alignment and evolutionary analysis (phylogenetic tree construction using Neighboring-Joining) using MEGA X software. Finally, they have been deposited and published on the GenBank platform. The results showed that HEV RNA was amplified by the liver of 114/1054 (10.81%) (102 GE/ μL) subjects tested, and 26/114 (22.81%) of them also presented positive muscle tissues too. None of them harbored HEV RNA in the muscle only. From a comparative and species point of view, wild boars presented a prevalence of 72/114 (63.16%), and domestic pigs of 42/114 (36.84%). The ORF-1 region was mostly amplified by 97/114 (85.08%) (103 GE/μL) of Suidae, while ORF-2 (102 GE/μL) only in the wild boar populations 72/114 (63.16%). In the period between 2020-2024, the loaded sequences on the GenBank platform were as follow: MN20202101, MN20202102, MN20202103, MN20202104, OR933697, OR93398, MN2020210201, MN2020210208, MN2020210212, ON364349, ON364350, ON364351, ON364352. In all positive cases, nucleotide similarity (over 98.0% average), alignments and phylogenetic analyses have demonstrated the involvement of HEV-3c during the five years 2020-2024. The radicalization of the presence and persistence of HEV-3c (from 2020 to 2024) in the Ascoli Piceno province confirms that the Suidae have a fundamental role as reservoirs in urban and wild cycles. The sharing of areas between extensive domestic pigs’ farms and the coexistence with wild boars within the Monti Sibillini National Park have allowed possible cross species -infection, as supported by the analysis of the discovered sequences. It is therefore clear that biomolecular surveillance on the territory has a fundamental role in terms of food safety and prevention for the final consumer
Proposal of a system for diagnosing with inefficient occupant behaviour and systems malfunctioning in the household sector
No full textOne of the key factors in curbing energy consumption in the household sector, together with energy efficiency and renewable energies, is widely recognized to be the amendment of occupant erroneous behaviour and systems malfunctioning, mainly explained by the lack of awareness of the final user.
The aim of this work is to propose a diagnostic system in the household sector which can improve the users’ awareness with respect to the energy consumption in final uses.
In particular, this paper presents an energy, environmental and economic analysis of different diagnostics systems, corresponding to different degrees of complexity and cost.
Given a reference occupancy and thermal user profile, for each diagnostic system the relevant energy consumption is assessed by simulation and the subsequent economic savings are calculated and compared to the diagnostic system cost in order to evaluate the payback period of the architecture proposed
Design and development of a web platform for the environmental monitoring of industrial emissions
No full textVascular endothelial growth factor/semaphorin-3A ratio and SEMA3A expression in cutaneous malignant melanoma
No full textBreslow thickness and Clark level are still important factors for cutaneous melanoma, but do not provide a precise prognosis in all cases. It is necessary to find new factors capable of a more accurate prediction of the tumor course. Angiogenesis is essential for tumor development and progression and is regulated by vascular endothelial growth factor A (VEGF-A) and semaphorins (SEMA), in particular, SEMA3A inhibits angiogenesis by affecting VEGF signaling. However, the prognostic role of angiogenetic factors remains unclear. To date, no information is available on SEMA3A in human melanoma. Microvessel density, immunohistochemical and mRNA VEGF and SEMA3A expression level in 60 thin (Breslow thickness ≤ 1.0 mm), 60 intermediate (1.1-4.0 mm) and 50 thick (>4.0 mm) primary human cutaneous melanomas were investigated and related to clinical/pathological parameters and disease-specific survival. No positive association between Breslow thickness, Clark level, metastasis presence and survival was identified; Clark level was poorly related to survival. VEGF and microvessel density were significantly higher in intermediate and thick melanomas and related to Breslow thickness and Clark level but not to metastasis status and survival. On the contrary, SEMA3A was significantly reduced in intermediate and thick melanomas and associated to metastasis and poor survival. VEGF/SEMA3A ratio was higher in the worst prognosis, resulting the most closely related factor with metastasis and survival. SEMA3A expression and VEGF/SEMA3A ratio turned out to be valuable prognostic biomarkers in patients affected by cutaneous melanoma, in particular with Breslow thickness >1 mm. SEMA3A might serve as a candidate tumor suppressor in cutaneous melanoma therapy
Malfunction and Bad Behavior Diagnosis on Domestic Environment
No full textAbstractGreenhouse gas emissions from homes arise primarily from fossil fuels burned for heat, the use of products that contain greenhouse gases, and the handling of waste. Human activities are responsible for almost all of the increase in greenhouse gases in the atmosphere over the last 150 years. The household sector is one of the biggest aggregate consumers and this is the reason why increasingly policies have been considering it. One of the key factors in curbing energy consumption in this sector is widely recognized to be due to erroneous behaviors and systems malfunctioning, mainly explained by the lack of awareness of the final user; so, training the final user to energy awareness can be more effective and cheaper than other policies. In this context, energy management in homes is playing, and will play even more in future, a key role in increasing the final consumer awareness towards its own energy consumption and consequently in bursting its active role in smart grids. The aim of this paper is to highlight the economic benefits of low cost intelligent control domestic devices, to identify energy behavior, system status and improve energy efficiency. The scope is to develop interaction between final users to create a network of energy consumption efficiency. The paper presents an application of Multi-scale Principal Component Analysis to diagnose inefficient occupant behavior and systems malfunctioning and suggest good practices of energy conservation
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