549 research outputs found
Rossardini, luthier des théâtres nationaux / grav. d'après G. Frison
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Fatality due to gamma-hydroxybutyric acid (GHB) and heroin intoxication
No full textThe first case of fatal intoxication due to ingestion of gamma- hydroxybutyric acid (GHB) and intravenous use of heroin i s reported. A 42- year-old man, known to have been a heroin addict and to have taken other psychoactive substances, who had been in treatment with GHB for several months, was found dead. Anatomohistopathologic examination showed generalized visceral congestion, edema and pulmonary anthracosis, chronic bronchitis and chronic active hepatitis. Toxicological findings included fluid and tissue distributions of GHB, morphine and 6-monoacetylmorphine. GHB and morphine concentrations were respectively 11.5 and 0.77 μ/mL (blood), 84.3 and 0.3 μg/mL (vitreous humor), 258.3 and 1.35 μg/mL (urine), 57.0 and 14.3 μg/mL (bile), 40.0 and 0.43 μg/g (brain), 43.0 and 0.60 μg/g (liver), 47.0 and 0.68 μg/g (kidney). Blood and urine levels of 6-monoacetylmorphine were 28.5 and 12.1 ng/mL respectively. The presumed mechanism of action and pharmacokinetics of GHB are briefly reviewed, with reference to its therapeutic use and to reports of non-fatal GHB intoxication
An improved method for cyanide determination in blood using solid-phase microextraction and gas chromatography/mass spectrometry
No full textA new method is described for the qualitative and quantitative analysis of cyanide, a very short-acting and powerful toxic agent, in human whole blood. It involves the conversion of cyanide into hydrogen cyanide and its subsequent headspace solid-phase microextraction (HS-SPME) and detection by gas chromatography/mass spectrometry (GC/MS) in selected ion monitoring (SIM) mode. Optimizing the conditions for the GC/MS (type of column, injection conditions, temperature program) and SPME (choice of SPME fiber, effect of salts, adsorption and desorption times, adsorption temperature) led to the choice of a 75-mu m carboxen/polydimethylsiloxane SPME fiber, with D-3-acetonitrile as internal standard, and a capillary GC column with a polar stationary phase. Method validation was carried out in terms of linearity, precision and accuracy in both aqueous solutions and blood. The limit of detection (LOD) and limit of quantitation (LOQ) were determined only in aqueous solutions. The assay is linear over three orders of magnitude (water 0.01-10, blood 0.05-10 mu g/mL); and the LOD and LOQ in water were 0.006 and 0.01 mu g/mL, respectively. Good intra- and inter-assay precision was obtained, always < 8%. The method is simple, fast and sensitive enough for the rapid diagnosis of cyanide intoxication in clinical and forensic toxicology
La Cronicha di Giorgio Dolfin (origini-1458) nel contesto culturale della Venezia del sec. XV
No full textA copy (XVI cent.) of a work entitled La Cronicha dela nobil cità de Venetia et dela sua provintia et destretto is preserved in the ms. It. VII, 794 (=8503), located at the Biblioteca Nazionale Marciana of Venice. The text documents the history of the city from its origins up to 1458. Its main author is Giorgio Dolfin (1396-1458), member of one of the most important Venetian aristocratic families; other contributors are Dolfin’s son Pietro, and Andrea and Nicolò Gussoni, the later owners of the volume containing the Cronicha. The chronicle remained unpublished up to the present day, although it represents a key source in the analysis of the work of Marin Sanudo the Younger (1466-1536), especially in regards to his digressions on number and inner workings of those Venetian judicial institutions assuring the good functioning of the Serenissima. Dolfin’s point of view is a profoundly religious one, aiming to represent Venetians as “veri et boni Christiani” and at the same time to celebrate their political and administrative independence. The events in the time of doge Francesco Foscari (1423-1457) are narrated in a truly passionate and affected manner, not only because the author and the Doge lived in the same period, but also because their two families were also related.La Cronicha dela nobil cità de Venetia et dela sua provintia et destretto (origini-1458) è conservata in una copia del XVI sec. nel manoscritto della Biblioteca Nazionale Marciana di Venezia It. VII, 794 (=8503) e racconta la storia di Venezia dalle origini al 1458. Il suo autore principale è Giorgio Dolfin (1396-1458), appartenente ad una delle maggiori famiglie del patriziato veneziano, ma contiene anche interventi del figlio Pietro e di Andrea e Nicolò Gussoni, successivi possessori del codice in cui è contenuta. La cronaca è rimasta inedita fino ai nostri giorni, pur costituendo una delle fonti principali per l’opera di Marin Sanudo il giovane (1466-1536), in particolare per la parte in cui si si dilunga ad elencare e spiegare le magistrature che riescono a garantire a Venezia il buon funzionamento dello Stato. Il punto di vista del Dolfin è profondamente religioso e mira a mettere in luce i Veneziani come “veri et boni Christiani” e la loro indipendenza politica ed amministrativa. Gli episodi relativi alle vicende del doge Francesco Foscari (1423-1457) sono raccontate in modo più accorato e commosso, sia perché contemporanee all’autore, sia perché i Dolfin erano legati da vincoli di parentela al doge
Dans l'Europe du Nord des Vlle-IXe siècles : commerce frison ou commerce franco-frison ?
No full textNorthern Europe from the 7th-9th Centuries: Frisian Trade or Frankish-Frisian Trade? S. Lebecq.
In this article, the author intends to make explicit some of the ideas put forward in his book: "Marchands et navigateurs frisons du Haut Moyen Age" (Lille, 1983). He wants to emphasize, in particular, the need for the "great Frisian trade" in the 7th-9th centuries not to be underrated, so long as, when evoking Friesland and the Frisians, one takes into account the reference in contemporary sources to a vast territory located between the Scheldt and the Weser; this includes the Rhine's great delta, dominated by Dorestad, whose population, at this point, was experiencing both the Frankish and Frisian apogee. Consequently, it appears that, while the Frisians were backing up this expansion in trade with their maritime experience and technique, which was unequalled to start with, the Franks doted it with a pacific and prosperous hinterland (at least as long as the apogee lasted), making efforts to integrate it within the framework of a genuine Northern policy, the aim of which was to penetrate the Northern countries whose threat was becoming more and more perceptible under Charlemagne and Louis the Pious.Lebecq Stéphane. Dans l'Europe du Nord des Vlle-IXe siècles : commerce frison ou commerce franco-frison ?. In: Annales. Économies, Sociétés, Civilisations. 41ᵉ année, N. 2, 1986. pp. 361-377
Full-Aeroelastic Model of CAARC Building: Iterative Design Procedure and Wind Tunnel Tests
No full textA first step of a broader framework, concerning the investigation of tall buildings’ dynamic response to wind load, is presented. In order to accomplish this challenging task, a well-known benchmark has been selected: the CAARC (Commonwealth Advisory Aeronautical Research Council) standard tall building. Decades of literatures on the subject make it the perfect candidate to tackle the complexity of wind-structure interaction phenomena. The present work concerns the design of a full-aeroelastic multi degrees of freedom model. The configuration proposed by J. Holmes at International Conference on Wind Engineering (2007), accounting for both flexural and torsional decoupled modes of vibrations, is adopted. A design theory present in literature is re-proposed, from a different prospective, in a semi-automated fashion through a Python script. At last, preliminary results are shown, demonstrating the method’s efficiency and applicability, not only to tall buildings, but more generally to structures with continuous distribution of mass
HFBB model test for tall buildings: A comparative benchmark with a full-aeroelastic model
No full textA novel approach to full-aeroelastic model design is presented, considering continuous structures and coupled modes. Its validity is proven by building a full-aeroelastic CAARC standard tall building model featuring 12-degrees-of-freedom at 1:360 scale. A complete description of its design, manufacturing, tuning, and dynamic identification is reported. The model is tested in a novel wind-tunnel experimental campaign performed at the CRIACIV facility (Prato, Italy). A comparative study of aerodynamic and full-aeroelastic response in terms of base moment and accelerations shows that the aerodynamic model tends to overpredict the response along the broader side of the model. The contribution of second modes is found to be relevant for induced acceleration at the rooftop
QUALITY CONTROL IN TOXICOLOGICAL ANALYSIS
No full textThe validity and effectiveness of quality control procedures are reviewed here in light of the principles of analytical toxicology, and of the professional responsibility involved in awareness of the profound influence which analytical results have in the fields of health and social security. Regardless of the methods used, laboratory work should aim essentially at achieving a very high degree of reliability. Factors contributing to the 'quality' of analytical results and methods used to check their reliability are discussed here. The technical background and organization of internal and external quality control procedures are presented, with particular reference to educational aspects, and to the ways in which computer and internet technologies may be exploited for further improvement of the effectiveness of these procedures
A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract.
No full textBeta-carboline alkaloids harmine, harmaline, and tetrahydroharmine can stimulate the central nervous system by inhibiting the metabolism of amine neurotransmitters, or by direct interaction with specific receptors; they are found in numerous plants, including Peganum harmala, Passiflora incarnata and Banisteriopsis caapi, and in the entheogen preparation Ayahuasca, which is traditionally brewed using B. caapi to enhance the activity of amine hallucinogenic drugs. The ingestion of plant preparations containing beta-carboline alkaloids may result in toxic effects, namely visual and auditory hallucinations, locomotor ataxia, nausea, vomiting, confusion and agitation. We report a case of intoxication following intentional ingestion of P. harmala seed infusion; P. harmala seeds were bought over the Internet. The harmala alkaloids were identified by gas chromatography-mass spectrometry in the seed extract and the patient's urine. This is, to our knowledge, the first case of P. harmala intoxication corroborated by toxicological findings
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