1,008 research outputs found
Land and changing social relations in South Africa's former reserves : the case of Luphaphasi in Sakhisizwe Local Municipality, Eastern Cape.
No full textIncludes abstract.
Includes bibliographical references
Le miniature del Vangelo arabo della Biblioteca Medicea Laurenziana di Firenze, codice Orientali 387 (Mardin, 1299 d.C.)
No full textEdizione facsimilare del manoscritto con introduzione al testo e descrizione delle miniature. A cura di Sara Fani la sezione "c. Il restauro del codice" pp. 317-319 e le interpretazioni del colophon e delle didascalie delle miniature
Reference Intervals and innovative parameters using Sysmex XN-2000V in horses
No full textThe evaluation of the hemogram is a key component in diagnosing diseases and monitoring animal health. This study aims to establish reference intervals (RIs) for healthy horses using a next-generation hematology analyzer designed for veterinary medicine (Sysmex XN-2000V). In addition to conventional hemogram parameters, this instrument provides innovative indices such as immature reticulocyte fraction (IRF) and can determine platelet count by three methods: impedance (PLT-I), optical (PLT-O), and fluorescence (PLT-F). Moreover, a specific fluorescent platelet channel can determine an important thrombopoietic marker named immature platelets fraction (IPF).
For this study, hemograms from 50 clinically healthy adult horses were analyzed. Mean, median and standard deviation were assessed, and RIs were calculated using the percentile method (2.5%; 97.5%). The following RIs were determined: HCT (26.94–39.24 %), HGB (9.89–14.10 g/dl), RBC (5.5–8.3 10^6/μL), MCH (15.52–17.90 g/dl), MCHC (34.16–37.40 g/dl), MCV (43.13–50.04 fL), RDW (19.4–22.27 %), RET-HE (18.90–24.50 pg), RETICULOCYTES (0.05–0.22 %), RPI (0.00–0.10), WBC (4.50–8.70 10^3/μL), corrected WBC (4.50–8.70 10^3/μL), BAS (0.00–0.10 10^3//μL), EOS (0.00–0.30 10^3/μL), LYMPH (1.30–3.47 10^3/μL), MON (0.20–0.40 10^3/μL), NEU (2.40–5.41 10^3/μL), MPV (7.12–8.70 fL), PCT (0.08–0.13 %), PLT-I (61.20–152.80 10^3/μL), PLT-O (96.90–170.00 10^3/μL), PLT-F (96.75–160.60 10^3/μL), HFR (0.00–11.40 %), IRF (0.00–11.8 7%), LFR (59.95–100.00 %), MFR (0.00–2.14%), IPF (0.30–4.06 %), PDW (6.51–15.21 fL), P-LCR (4.32–15.21 %), IPF# (0.4–4.14 10^3/μL).
Establishing species-specific RIs based on the analytical instrument used is essential for accurately assessing the health status of both healthy and diseased horses, covering both standard and innovative parameters.
[1] O. Jornet-Rius, M. Mesalles-Naranjo and J. Pastor, “Performance of the Sysmex XN-V hematology analyzer in determining the immature platelet fraction in dogs: A preliminary study and reference values”, Vet. Clin. Pathol., vol 52, pp. 433-442, 2023
[2] K.R. Friedrichs, K.E. Harr, K.P. Freeman, B. Szladovits, R.M. Walton, K.F Barnhart and J. Blanco-Chavez, “ASVCP reference interval guidelines: determination of de novo reference intervals in veterinary species and other related topics”, Vet. Clin. Pathol, vol. 41, pp. 441-453, 2012
[3] A. Gavazza, C. Fani, C. Masci and G. Rossi, “Performance of platelet determination using the Sysmex XN 2000V analyzer and reference intervals in horses”, Proc. 26th ESVCP Congress, Budapest, pp. 140, August 2024
[4] M. Quagliardi, L. Galosi, G. Rossi, A. Roncarati and A. Gavazza, “Reference Intervals (RIs) in Veterinary Medicine”, ACTA IMEKO, vol 13, pp 1 – 5, 202
Stability analysis and control of the flow in a symmetric channel with a sudden expansion
No full textThe laminar flow in two-dimensional diffusers may produce either symmetric or nonsymmetric steady solutions, depending on the value of the Reynolds number as compared with some critical value. The stability properties of the flow are studied in the context of linear theory. In this context, a sensitivity analysis of the flow instability is carried out with respect to perturbations that may be produced by a realistic passive control, thus providing qualitative hints and quantitative information for the control design. Following the so-obtained information, a passive control is built by introducing a small cylinder in the flow with the aim of stabilizing the unstable symmetric flow configuration in the diffuser. The effectiveness of this control is finally assessed by direct numerical simulation. It is shown that the introduction of the cylinder, placed following the indications of the linear sensitivity analysis in the stable asymmetric flow configuration, allows a steady completely symmetric or less asymmetric flow to be recovered. The flow transient between the uncontrolled asymmetric solution and the symmetric controlled one is analyzed in terms of streamlines and vorticity evolution; the effects of the cylinder introduction on flow dissipation are also assessed
Integrated simulation and optimization of continuous pharmaceutical manufacturing
No full textThe goal of this work focuses mainly in the development of reduced-order modeling tools for the design and optimization of manufacturing of pharmaceutical oral solid dosage form products. This work- as part of a collective effort of the Engineering Research Center for Structured Organic Particulate Systems (ERC-SOPS)- aims to combine all the research findings of the Center in terms of material properties and process understanding in order to design efficient continuous integrated manufacturing processes. Different surrogate-based methodologies are assessed for reduced-order model building based on either experimental data or computer simulation data. In addition, the effects of uncertainty of the available data, material properties and model parameters on model performance are addressed systematically. Finally, unit operation models are combined into a flowsheet simulation model which can be used for process design through the development of a simulation-based optimization strategy for noisy expensive flowsheets with complex constraints.Ph. D.Includes bibliographical referencesIncludes vitaby Fani Boukouval
Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy
No full textAmyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions are neurodegenerative disorders that share the cytosolic deposition of TDP-43 (TAR DNA-binding protein 43) in the CNS. TDP-43 is well known as being actively degraded by both the proteasome and macroautophagy. The well-documented decrease in the efficiency of these clearance systems in aging and neurodegeneration, as well as the genetic evidence that many of the familial forms of TDP-43 proteinopathies involve genes that are associated with them, suggest that a failure of these protein degradation systems is a major factor that contributes to the onset of TDP-43-associated disorders. Here, we inserted preformed human TDP-43 aggregates in the cytosol of murine NSC34 and N2a cells in diffuse form and observed their degradation under conditions in which exogenous TDP-43 is not expressed and endogenous nuclear TDP-43 is not recruited, thereby allowing a time zero to be established in TDP-43 degradation and to observe its disposal kinetically and analytically. TDP-43 degradation was observed in the absence and presence of selective inhibitors and small interfering RNAs against the proteasome and autophagy. We found that cytosolic diffuse aggregates of TDP-43 can be distinguished in 3 different classes on the basis of their vulnerability to degradation, which contributed to the definition-with previous reports-of a total of 6 distinct classes of misfolded TDP-43 species that range from soluble monomer to undegradable macroaggregates. We also found that the proteasome and macroautophagy-degradable pools of TDP-43 are fully distinguishable, rather than in equilibrium between them on the time scale required for degradation, and that a significant crosstalk exists between the 2 degradation processes.-Cascella, R., Fani, G., Capitini, C., Rusmini, P., Poletti, A., Cecchi, C., Chiti, F. Quantitative assessment of the degradation of aggregated TDP-43 mediated by the ubiquitin proteasome system and macroautophagy
A Memorandum Outlining the Diplomatic Relations of the Holy See with Persia in the Last Decades of the Sixteenth Century (ASF, Misc. Med. 719, ins. 56.2)
No full textEdizione diplomatica e ampia introduzione a un documento conservato presso l'Archivio di Stato di Firenze redatto da Giovanni Battista Raimondi, direttore scientifico della Typographia Medicea delle lingue orientali, in cui vengono messi in evidenza i rapporti diplomatici della Sante sede con la Persia Safavide
Giovanni Battista Raimondi on the Management of the Typographia Vaticana (BNCF, Naz. II.V.157, fols 1r-6v)
No full textPubblicazione di un documento conservato presso la Biblioteca Nazionale Centrale di Firenze e relativo alla attività editoriali di Giovanni Battista Raimondi, direttore scientifico della Typographia Medicea. Edizione diplomatica del documento corredata di ampia introduzione che tratteggia le connessioni tra alcune officine tipografiche romane operanti alla fine del XVI secolo, e dedicate alla stampa di opere in lingue orientali
Giovanni Battista Raimondi’s Involvement in the Laminae Granatenses Affair (BNCF, II.V.157, fols 23r-34v; Magl. Cl.III.76)
No full textEdizione e ampio commento introduttivo di alcuni documenti relativi al coinvolgimento di Giovanni Battista Raimondi, direttore scientifico della Typografia Medicea delle lingue orientali nella vicenda delle celebri Laminae Granatensis. I documenti sono relativi ad un suo saggio di traduzione e analisi grammaticale di un estratto del testo delle Laminae
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