1,721,057 research outputs found
Direct deconvolution techniques for pool libraries of small organic molecules
No full textA review with 99 refs. on techniques for linking the structures of library components with specific parts of the library (wells, pools, single beads, etc.)
Encoding techniques for pool libraries of small organic molecules
No full textA review with 92 refs. The aim of this chapter is to provide helpful information to decide if, when, and how to apply any of the encoding techniques to the synthesis of libraries of any format. The complementarity, rather than mutual exclusion, of the different methods is often highlighted
Concepts of combinatorial chemistry and combinatorial technologies
No full textA survey of basic concepts of combinatorial chemistry and combinatorial technologies and a great impact of this new approach on the traditional chemistry is presented. The main fields of application of CC/CT are reviewed and the reasons why CC/CT is so strongly needed and demanded are given. Besides obvious utilization of CC/CT in drug discovery, agro-chemical research and research and development of new materials and catalysts also gain from this approach. The paper describes the origins and development of the technique, formed on the basis of probabilistic justifications. The applicability of combinatorial technologies and main combinatorial tools are described together with computer-assisted combinatorial chemistry, molecular design and biological methods of CC/CT. A list of important Web resources relevant to the topic is also presented
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