1,721,176 research outputs found
“Quale gerarchia? Capi ed esperti alla ricerca del proprio ruolo nei sistemi tecnologici integrati”
No full textImpresa, gruppi professionali e sindacato nella progettazione delle tecnologie informatiche. Metodi e forme di partecipazione
No full textQuaderni della Fondazione Adriano Olivetti ;
A mathematical model for the therapy of the HIV infection
No full textIn [17] it was introduced a model to describe the dynamics of the HIV infection when the
patient is under chemotherapy (either RTI or PI). The main idea in [17] was to introduce the
effectiveness of the drug as a dynamical variable.
In this paper we pursue this idea starting from an analysis of the fitness of the virus during
the therapy. We introduce an adaptive model in which the ability of the viruses to infect
the target cells is related to the number of contacts between viruses and T–cells that have
been inhibited by the drug. This approach is similar to the model proposed in [10] for a
predator-prey system. However the biological interpretation is different here because in our
context the adaptation of the virus is due to the development of resistant virus strains. We
analyze different combination therapies with three antiviral drugs, which consist of reverse
transcriptase inhibitor (RTI) and protease inhibitor (PI) and we show the possibility of very
long latency periods, during which the viral load goes below the detectable level. These
periods are followed by a rebound followed by the re–establishing of the conditions previous
to the therapy. This dynamics is in good qualitative agreement with the available clinical
data
Passato, presente e possibile futuro della valutazione individuale nella pubblica amministrazione
No full textLa contrattazione collettiva : un nuovo equilibrio tra centralizzazione e decentramento?
No full text
Toxicity of some synthetic pyrethroids to red swamp crayfish (Procambarus clarkii, Girard 1852) and common carp (Cyprinus carpio, L. 1758), in laboratory tests.
No full text
Pharmacokinetics and residue depletion of erythromycin in gilthead sea bream Sparus aurata L. after oral administration
No full textErythromycin (ERY) is an antibiotic effective against Streptococcus iniae, a microorganism responsible for significant losses in aquaculture. No data are available on the pharmacokinetics and residue depletion of ERY in sea bream. The aim of this study was thus to evaluate the pharmacokinetics of ERY in this species after a single oral administration at 75 mg kg-1 b.w. and to assess its residue depletion from tissues after prolonged treatment for 10 days. ERY was rapidly absorbed in sea bream (Cmax = 10.04 μg g-1 and Tmax=1 h), with a half-life of 9.35 h and an AUC0-24 of 56.81 (h μg mL-1). The data obtained and the evaluation of pharmacokinetic/pharmacodynamic parameters allowed us to hypothesize that dosage used in this study should be effective against S. iniae. A rapid reduction in erythromycin concentrations was observed in tissues, with the drug being detectable only during the first day post-treatment. In Europe, the use of ERY in aquaculture is allowed by off-label prescription with a withdrawal time of 500 °C day-1. The absence of ERY residues in tissues already at 24 h post-treatment suggests that ERY in sea bream should not pose human food safety issues
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