30,569 research outputs found
Euraca Seminary. L/E/N/G/UA/J/E/o: Dispositivo transatlántico de publicación & republicación de textos del Seminario Euraca
No full textEuraca Seminary. L/E/N/G/UA/J/E/o: Dispositivo transatlántico de publicación & republicación de textos del Seminario Euraca. Septiembre 2017 (1), Madriz. Web: seminarioeuraca.wordpress.com/revista-lenguajeo
Seminario Euraca. L/E/N/G/UA/J/E/o: Dispositivo transatlántico de publicación & republicación de textos del Seminario Euraca
No full textSeminario Euraca. L/E/N/G/UA/J/E/o: Dispositivo transatlántico de publicación & republicación de textos del Seminario Euraca. Septiembre 2017 (1), Madriz. Web: seminarioeuraca.wordpress.com/revista-lenguajeo
Effect of electromagnetic field exposure on the transcription of repetitive DNA elements in human cells
No full textRepetitive DNA (RE-DNA) was long thought to be silent and inert; only recent research has shown that it can be transcribed and that transcription alteration can be induced by environmental stress conditions, causing human pathological effects. The aim of this study was to determine whether exposure to radiofrequency electromagnetic fields (RF-EMF) could affect the transcription of RE-DNA. To this purpose, three different human cell lines (HeLa, BE(2)C and SH-SY5Y) were exposed to 900 MHz GSM-modulated RF-EMF at specific absorption rate of 1 W/kg or to sham. After exposure, mRNA levels of RE-DNA were evaluated through quantitative real-time PCR. The following RE-DNA types were investigated: Long Interspersed nucleotide Element 1, DNA alpha satellite and Human Endogenous Retroviruses-like sequences. When comparing cells exposed to RF-EMF versus control samples, different results were found for the three cell lines evaluated, indicating that RF-EMF exposure can significantly affect RE-DNA transcription and that the effects strongly depend on the cellular context and the tissue type. Further studies are needed to elucidate which molecular mechanisms could be involved
Epílogo. Una vida más alla del trabajo=Epilogue. A Life Beyond Work
No full textEpílogo del libro El problema del trabajo, Madrid, Traficantes de sueños, 2020.Cesión por parte de la autora y la editorial Epilogue of the book The problem with work, Madrid, Traficantes de sueños, 2020.Assignment by the author and publishe
Corrosione sotto sforzo e infragilimento da idrogeno. Esperienze del Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta” del Politecnico di Milano
No full textL’interesse del Dipartimento di Chimica, Materiali e Ingegneria Chimica “G. Natta” del Politecnico di Milano per i fenomeni di corrosione sotto sforzo, corrosione-fatica e infragilimento da idrogeno nei metalli e per le problematiche ingegneristiche legate a questa famiglia di fenomeni risale almeno agli anni ’70 del secolo scorso. In quel periodo Pietro Pedeferri, Bruno Mazza e Dany Sinigaglia si occuparono, in collaborazione con aziende e centri di ricerca, di alcune delle problematiche più importanti, come la corrosione fatica delle strutture offshore e la corrosione sotto sforzo nell’estrazione e trasporto degli idrocarburi. Il contributo della scuola di Pietro Pedeferri è stato relativo sia all’avanzamento delle conoscenze scientifiche, sia all’innovazione metodologica (applicazioni della meccanica della frattura, della microscopia elettronica ...), sia alla divulgazione. L’attività proseguì nei decenni successivi coinvolgendo anche altri ambiti di ricerca, quali la corrosione delle armature nel calcestruzzo e la sua prevenzione. Nell’articolo sono richiamati anche altri argomenti più specialistici affrontati nei decenni successivi e la collaborazione con il Dipartimento di Meccanica del Politecnico di Milano sul comportamento di diverse classi di acciai in ambienti che promuovono l’assorbimento di idrogeno, iniziata negli anni ‘2000 e che prosegue tuttora
Conversatorio con Lisa Garforth=Conversation with Lisa Garforth
No full textJulia Ramírez-Blanco conversa con Lisa Garforth, autora del libro Green Utopias y especialista en utopías medioambientales. Con ella, hablamos acerca de las posibles maneras de definir las ecotopías, y cómo estas se manifiestan tanto en la literatura como en distintas formas de práctica social.Julia Ramírez-Blanco interviews Lisa Garforth, author of the book Green Utopias and specialist in environmental utopias. With her, we talk about the possible ways of defining ecotopias, and how they manifest themselves both in literature and in different forms of social practice.http://re-visiones.net/audio/Entrevista-Lisa-Garfoth.mp
Long INterspersed element-1 mobility as a sensor of environmental stresses
No full textLong INterspersed element (LINE-1, L1) retrotransposons are the most abundant transposable elements in the human genome, constituting approximately 17%. They move by a “copy-paste” mechanism, involving reverse transcription of an RNA intermediate and insertion of its cDNA copy at a new site in the genome. L1 retrotransposition (L1-RTP) can cause insertional mutations, alter gene expression, transduce exons, and induce epigenetic dysregulation. L1-RTP is generally repressed; however, a number of observations collected over about 15 years revealed that it can occur in response to environmental stresses. Moreover, emerging evidence indicates that L1-RTP can play a role in the onset of several neurological and oncological diseases in humans. In recent years, great attention has been paid to the exposome paradigm, which proposes that health effects of an environmental factor should be evaluated considering both cumulative environmental exposures and the endogenous processes resulting from the biological response. L1-RTP could be an endogenous process considered for this application. Here, we summarize the current understanding of environmental factors that can affect the retrotransposition of human L1 elements. Evidence indicates that L1-RTP alteration is triggered by numerous and various environmental stressors, such as chemical agents (heavy metals, carcinogens, oxidants, and drugs), physical agents (ionizing and non-ionizing radiations), and experiential factors (voluntary exercise, social isolation, maternal care, and environmental light/dark cycles). These data come from in vitro studies on cell lines and in vivo studies on transgenic animals: future investigations should be focused on physiologically relevant models to gain a better understanding of this topic
Surface electrostatic potentials on macromolecules in a monopole approximation: a computer program and an application to cytochromes.
No full textA new tool for detg. and analyzing mol. electrostatic potentials (MEP) of very large biomols. is presented and illustrated. The MEP's are computed in a monopole approxn. with inclusion of inductive effects by a chain of computer programs (running even on small computers) based on net charges calcd. in a σ-π sepn. scheme according to the method of G. Del Re (1964). This method is applicable to virtually any macromol. and yields fairly reliable net charges. The use of MEP's in the study of reaction mechanisms as well as the solvent problem and use of ad hoc dielec. consts. are briefly discussed. Since MEP's are esp. well suited to the study of oxido-reaction mechanisms, the scope of the new program is illustrated on the maps of reduced and oxidized states of some monoheme cytochromes at their van der Waals frontiers. The results throw further light on the way in which the protein modulates the properties of the heme grou
Prefazione a: René Thom: Prevedere non è spiegare
No full textsi inquadra la ristampa in nuova edizione italiana dello scritto di Thom nella sua concezione generale della matematica di tipo qualitativo e relazionale e non banalmente quantitativo con riferimento sia all'adesione di Thom alla visione aristotelica della scienza sia alla sua teoria delle catastrofi e al suo approccio modellistico e dinamico. Se ne illustrano quindi sia gli aspetti filosofico-epistemologici sia quelli più tecnic
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