5 research outputs found
Localization of the pathogenic gene of Behçet's disease by microsatellite analysis of three different populations
No full text
Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian
No full textWe recently identified a trinucleotide repeat polymorphism, (GCT)n, within the transmembrane (TM) segment of the human MHC class I MICA gene (MHC class I chain-related gene A). Five distinct alleles (A4, A5, A5.1, A6, A9) corresponding to 4, 5, 5 with one nucleotide insertion, 6 and 9 repetitions, respectively, have been detected in various HLA homozygous B cell lines. Here we present allele frequencies for this trimeric short tandem repeat (STR) in 604 unrelated individuals collected from nine human populations (Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian) determined using the polymerase chain reaction (PCR) combined with fluorescent-based automated fragment detection technology. All alleles were present in each population, but allelic distributions varied from one population to another. No new alleles (such as A7 or A8) were identified. The evolutionary and structural significance of these data as well as the potential application to forensic medicine is discussed
Cultural perspectives on the meaning of corporate social responsibility in a third sector organisation
No full textHow can Corporate Social Responsibility best be understood, what is its range of application and what insights can culture provide when considering the responsibilities of a third sector organisation? This thesis addresses these questions through ethnographic enquiry conducted in a third sector organization (Groundwork Northumberland). Challenging the rigid conventions which restrict the relevance of Corporate Social Responsibility to the private sector it demonstrates both the contest and construction of meaning and frame of reference of Corporate Social Responsibility by employees in Groundwork Northumberland. All eight members of the organization have participated by engaging in semi-structured interviews (with me), keeping a research diary (individually) and participating in a focus group (with colleagues). These engagements have generated multiple accounts which demonstrate the tensions and dilemmas that mark their work, particularly in meeting expectations of stakeholders. Through these engagements the self-understandings of participants are shown to have been challenged and changed through the research process. Equally the ‘concept’ of Corporate Social Responsibility has been shown to be similarly changeable while remaining unintelligible outside a context of practice in which at least some self-understandings are shared. Martin’s framework has been considered as a means to represent the culture of the organisation. The third perspective highlighting ambiguity, paradox and contradiction seems to best represent the accounts of the research engagement with GN. The presence of tension and difference as well as a sense of disorder suggest a place for debate, discussion and plurivocality, a place in which there is indecision and the possibility of decision (Derrida). It can therefore be suggested that a responsible organization and person will be more marked by fragmentation than integration or differentiation, and that fragmentation provides conditions which Derrida discusses through the terms ‘aporia’ and ‘undecidability’. These accounts exhibit the radical undecidability of Derrida’s ethical situation in all its lived messiness. The culture of an organization which has engaged in such meaning construction is shown to be marked by the acknowledgment of the responsibility of meaning-making and is aporetic. The contribution of this thesis is to demonstrate the responsibilities inherent to an engagement with the precariousness of meaning exhibited by Corporate Social Responsibility in an organization which has chosen such engagement
