206 research outputs found
CAD tools for control design in linear periodic discrete-time systems subject to input constraints
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Use of trace elements in therapy of secretory otitis media; preliminary results [Uso di oligoelementi nella terapia dell'otite media secretiva; primi risultati]
No full textAfter a brief review of the evolution of knowledge, empirical at first and subsequently scientific, concerning trace elements and their therapeutic use, the authors describe their mechanism of action. The effects of treatment with trace elements have been tested in 100 children aged 6 to 14 and suffering from mono or bilateral secretory otitis media. Above, the results are reported of a preliminary study in 24 children. In addition to history, the following explorations were performed before, and after every month of treatment: ORL-examination, audiometry, tympanometry, tubal patency and time of nasal muco-ciliary transport. The children were divided into four groups: one group was not submitted to any treatment, one was submitted to traditional treatment consisting of the administration of an antiinflammatory and a mucolytic agent for the first 10 days of each of four consecutive months; one was treated with trace elements, Mn and Cu in an single 2 ml dose daily throughout the study period, and one group received both traditional and trace element treatment. On the basis of the results obtained and of their statistical evaluation, the authors conclude that the group submitted to traditional treatment plus trace elements had the best results
Resistance to azetidine-2-carboxylic acid and sodium chloride tolerance in carrot cell cultures and Spirulina platensis.
No full textMutants of Spirulina platensis and of Daucus carota resistant to azetidine-2-carboxylic acid were tested for NaCl tolerance. A positive correlation was found between proline overproduction and osmotolerance. In carrot lines proline overproduction was not strictly proportional to NaCl tolerance insofar as cells characterized by differences in proline overproduction showed similar osmotolerance, suggesting that other factors could be involved
Evaluation of antioxidant, antimicrobial and tyrosinase inhibitory activities of extracts from tricholosporum goniospermum, an edible wild mushroom
No full textTricholosporum goniospermum (Bres.) Guzmán ex T.J. Baroni is an excellent edible mushroom whose compounds and biological properties are still unknown. In this study, n-hexane, ethyl acetate and methanol extracts from fruiting bodies and liquid-cultured mycelia were compared for the analysis of phenolic compounds, the evaluation of scavenger (DPPH, ABTS) and reducing (CUPRAC, FRAP) activities, and the enzyme inhibition of α-amylase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase. Additionally, T. goniospermum extracts were evaluated for antibacterial and antimycotic activities against Gram+ and Gram- bacteria, and clinical yeast and fungal dermatophytes. Finally, based on the extract content in phenolic compounds, in silico studies, including the docking approach, were conducted to predict the putative targets (namely tyrosinase, lanosterol-14-α-demethylase, the multidrug efflux system transporters of E. coli (mdtK) and P. aeruginosa (pmpM), and S. aureus β-lactamase (ORF259)) underlying the observed bio-pharmacological and microbiological effects. The methanolic extract from mycelia was the richest in gallic acid, whereas the ethyl acetate extract from fruiting bodies was the sole extract to show levels of catechin. Specifically, docking runs demonstrated an affinity of catechin towards all docked proteins, in the micromolar range. These in silico data are consistent, at least in part, with the highest activity of ethyl acetate extract as an antimicrobial and anti-tyrosinase (554.30 mg KAE/g for fruiting bodies and 412.81 mg KAE/g for mycelia) agent. The ethyl acetate extracts were also noted as being the most active (2.97 mmol ACAE/g for fruiting bodies and 2.25 mmol ACAE/g for mycelia) on α-amylase. BChE inhibitory activities varied from 2.61 to 26.78 mg GALAE/g, while the tested extracts were not active on AChE. In conclusion, all mushroom extracts tested in this study had potent antimicrobial activities. Particularly, among the tested extracts, the ethyl acetate extract showed the highest efficacy as both an antimicrobial and anti-tyrosinase agent. This could be related, albeit partially, to its content of catechin. In this regard, the bioinformatics analyses showed interactions of catechin with tyrosinase and specific microbial proteins involved in the resistance to chemotherapeutic drugs, thus suggesting innovative pharmacological applications of T. goniospermum extracts
Resistance to azetidin-2-carboxylic acid and sodium chloride tolerance in carrot cell cultures and Spirulina platensis.
No full textMutants of Spirulina platensis and of Daucus carota resistant to azetidine-2carboxylic acid were tested for NaCl tolerance. A positivr correlation was found between proline overproduction and osmotolerance. In carrot lines proline overproduction was not strictly proportional to NaCl tolerance insofar as cells chracterized by differences in proline overproduction showed similar osmotolerance, suggesting that pother factors could be involved
Bioremediation of cultual heritage: removal of sulphates, nitrates and organic substances
No full text
Correction to: Effectiveness and Safety of Different Vascular Closure Devices: Multicentre Prospective Observational Study (CardioVascular and Interventional Radiology, (2023), 46, 7, (827-834), 10.1007/s00270-023-03463-5)
No full textIn the original text, Claudio Carrubba’s name was misspelled as Claudio Carruba in the authors list. The correct authors list for the article Effectiveness and Safety of Different Vascular Closure Devices: Multicentre Prospective Observational study is therefore: Anna Maria Ierardi, Andrea Coppola, Matteo Renzulli, Filippo Piacentino, Federico Fontana, Andrea Paladini, Giuseppe Guzzardi, Vittorio Semeraro, Carmine Di Stasi, Francesco Giurazza, Raffaella Niola, Matteo Stefanini, Andrea Contegiacomo, Claudio Carrubba, Andrea Discalzi, Fernanda Ciferri, Serena Carriero, Carolina Lanza, Pierpaolo Biondetti, Giovanni Coniglio, Paolo Fonio, Massimo Venturini, Gianpaolo Carrafiello & Costantino Del Giudice
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