771 research outputs found
Exposure to the agricultural fungicide tebuconazole promotes Aspergillus fumigatus cross-resistance to clinical azoles. [Comini S. is the co-first author; Banche G. is the corresponding author; Cuffini A.M. is the co-corresponding author]
No full textResistance to clinical triazoles in Aspergillus fumigatus is a growing concern for individuals at high risk of Aspergillus infection. Two triazole resistance selection routes are currently being investigated: one occurring in triazole-treated patients in healthcare settings, and the second taking place in the environment due to the widespread use of agricultural triazoles. This study aimed to assess the ability of agricultural azoles to promote cross-resistance to clinical azoles in A. fumigatus. Five A. fumigatus isolates susceptible to clinical azoles were exposed to the triazole 14α-demethylase inhibitor, tebuconazole (TBC), and then antifungal susceptibility tests for voriconazole, itraconazole, posaconazole and isavuconazole were performed. Under TBC selection pressure, all A. fumigatus isolates exhibited resistance to clinical triazoles. However, only two displayed a multiresistant phenotype to clinical azoles. TBC exposure was also associated with delayed conidia formation and progressive absence of conidiation. Noteworthy, no TBC-exposed clones harbored TR34/L98H mutation, as judged by real-time PCR assays. The observation that TBC exposure promotes cross-resistance to clinical triazoles warrants careful and thorough assessment of the human health risk associated with agricultural azoles. The absence of TR34/L98H mutation in cross-resistant A. fumigatus isolates suggests that other cyp51A mutations may be involved in clinical azole cross-resistance
Compositionality properties of SLD-derivations
No full textThe paper introduces a semantics for definite logic programs expressed in terms of SLD-derivations and studies various properties of SLD-derivations by using the above semantics, The semantics of a program is a goal-independent denotation, which can equivalently be specified by a denotational semantics and a transition system. The denotation is proved to be correct, minimal, AND-compositional and OR-compositional. The denotational semantics and the transition system are defined in terms of a set of primitive semantic operators, whose properties are directly related to the properties of the denotation. The SLD-derivations semantics has been designed to act as collecting semantics for a framework of abstract semantics (Comini et al., 1995, 1996). (C) 1999-Elsevier Science B.V. All rights reserved
Evaluation of the Amplex eazyplex SuperBug Acineto test for direct detection of multidrug- resistant Acinetobacter baumannii bloodstream infections in high endemicity settings [S. Comini is the corresponding author]
No full textA Streamfunction-Vorticity Based Finite-Element Formulation for Laminar-Convection Problems
No full textOpen Boundary Conditions for the Streamfunction-Vorticity Formulation of Unsteady Laminar Convection
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INFLOW AND OUTFLOW BOUNDARY CONDITIONS IN THE FINITE ELEMENT SOLUTION OF THE STREAMFUNCTION-VORTICITY EQUATIONS
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