615 research outputs found
ALPHA(2)-ADRENERGIC RECEPTOR SENSITIVITY IN PANIC DISORDER .1. GH RESPONSE TO GHRH AND CLONIDINE STIMULATION IN PANIC DISORDER
No full textBaseline levels of GH and somatomedin C (SmC) and GH responses to GHRH (1 mu g/kg b.w.) and to clonidine (150 mu g) were measured in 10 outpatients with panic disorder before and after 30 days of 2-2.5 mg of alprazolam therapy, and in 10 psychophysically healthy controls. Basal levels of GH were normal in the patients and those of SmC significantly elevated, both before and after therapy. Basal GH responses to GHRH stimulation were normal and did not change after alprazolam treatment. Basal GH responses to clonidine stimulation were blunted in the patients and improved after therapy, in parallel with an amelioration of the psychopathology. Our data suggest that adrenoceptor sensitivity, investigated by the clonidine test, is reduced in panic disorder
ALPHA(2)-ADRENERGIC RECEPTOR SENSITIVITY IN PANIC DISORDER .2. CORTISOL RESPONSE TO CLONIDINE STIMULATION IN PANIC DISORDER
No full textThe cortisol responses to acute administration of saline and of clonidine (Cion), 150 mu g IV, were examined in 12 patients with panic disorder and agoraphobia, before and after 32 days of alprazolam therapy (2.5 mg/day), and in 12 normal controls. The responses in the Clon test corrected for the responses to saline differed in the two groups, and in patients were not changed by the therapy even though significant symptomatological improvement was achieved. The results suggest that presynaptic alpha(2)- or postsynaptic alpha(1)-beta-adrenoceptor sensitivity is impaired in panic disorder
Alle origini del divieto di domande suggestive ai testimoni
No full textLe origini dell'odierno divieto, previsto dal codice di procedura penale, di porre domande suggestive ai testimoni, nell'ambito dell'individuazione di una corretta metodologia di interrogatorio.
Ricostruzione del percorso legislativo e giurisprudenziale che ha portato all'elaborazione di uno dei cardini dell'odierno processo penale
The five “Ws” for bone pain due to the administration of granulocyte-colony stimulating factors (G-CSFs)
No full textGranulocyte-colony stimulating factors (G-CSFs) are commonly employed in clinical practice. The most relevant adverse event of G-CSF administration is bone pain. Approximately 20% of cancer patients experienced bone pain with the administration of prophylactic daily G-CSFs (lenograstim and filgrastim). The reported incidence of bone pain in cancer patients undergoing pegfilgrastim prophylaxis ranged from 25% to 38%. In healthy donors the incidence of bone pain was higher than in cancer patients, ranging from 52% to 84%. There are four main causes of G-CSF related bone pain: bone marrow quantitative and qualitative expansion, peripheral nociceptor sensitization to nociceptive stimuli, modulation of immune function and direct effect on bone metabolism. For the prevention and treatment of bone pain occurring after or during GCSFs administration, acetaminophen and nonsteroidal anti-inflammatory agents are commonly used as first-line treatment; antihistamines, opioids and dose reduction of G-CSFs are considered as second line therapy. The only randomized clinical trial conducted for the prevention and treatment of G-CSF induced bone pain showed the efficacy of naproxen in reducing the incidence, the severity and the duration of bone pain induced by the administration of pegfilgrastim. (C) 2013 Elsevier Ireland Ltd. All rights reserved
Obsessive compulsive disorder and mood disorders: A family study
No full textObsessive compulsive disorder (OCD) often coexists with major depression (MD), with rates varying from 35 to 75%. The nature of the depressive symptomatology can be investigated by familial aggregation analysis, assuming that the disorder which occurs first is the one showing greater genetic liability and should have higher familial concentration. Therefore, the aim of our study was to assess the familial loading for OCD and mood disorders in the families of OCD patients with different chronology of onset for the mood disorder, to evaluate how the familial pattern of the diseases differs with different temporal sequences in which the two syndromes occur, A total of 172 OCD patients entered the study; 112 were pure OCD probands, 12 were unable to separate the onset of the two syndromes, 11 had prior mood disorder, and 37 of them had experienced their first depressive episodes after the onset of OCD. Information about the family history was collected by means of the Family History-Research Diagnostic Criteria (FH-RDC) and by directly interviewing at least 2 relatives per family. Morbidity risks for OCD indicate a familial concentration of the disorder in all groups, except the MD/OCD group. We found the highest rate of relatives affected by mood disorders in the families of patients with first onset of MD (28.8%), whereas in the other 3 groups MRs were much lower, These results suggest the affective nature of OCD patients who experienced first onset of MD. Thus, the chronology of onset seems to identify 2 different typologies of familial distribution. (C) 1995 Wiley-Liss, Inc. Z8 0 ZR 0 ZS
El capitán Bellodi, o el escándalo de la lechuza cuando de día aparece
No full textLeonardo Sciascia, escritor siciliano, considera la literatura como escritura para aludir a personajes y situaciones que no caben en el periodismo y el ensayo. Su literatura es una constante reflexión crítica en torno a temas de justicia, legalidad y criminalidad en Italia. La construcción del personaje central de su novela El día de la lechuza, (1961), el capitán Bellodi, le permite ahondar en la realidad siciliana de la mafia, denunciar el sistema político y social que permite su existencia sin dejar de apostarle a la fuerza de las instituciones democráticas como la justicia y la ley.Leonardo Sciascia's writing, and more specifically his novel The Day of the Owl, is an example of how literature can dialogue with the world of law, urging reflection on the reality of violence, injustice and impunity. The author chooses the literary genre of the novel to say other things, to allude to characters and situations that do not fit in journalism and essays. His literature is a constant critical reflection on issues of justice, legality and criminality in Italy. The construction of the central character, Captain Bellodi, allows him to delve into the Sicilian reality of the mafia, denouncing the political and social system that allows its existence while at the same time relying on the strength of democratic institutions such as justice and the law.Primera edición
Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I Growth hormone Response to Clonidine stimulation
No full textIn 15 patients with obsessive-compulsive disorder (OCD) and in 15 healthy controls postsynaptic alpha-2-adrenoceptor sensitivity was examined by measuring the growth hormone (GH) response to growth hormone-releasing hormone (GHRH) and to clonidine stimulation. Basal values of GH and somatomedin-C (SMD-C) and mean GH responses to GHRH were the same in patients and controls, thus suggesting that a peripheral pathology of the somatotropic axis should not be present. GH responses to clonidine stimulation were blunted in patients suggesting that post-synaptic alpha-2-adrenoceptors are subsensitive, possibly due to higher than normal noradrenergic secretion
Approximate entropy of respiratory patterns in panic disorder
No full textOBJECTIVE: Considerable evidence suggests a connection between panic disorder and respiration, but the nature of the respiratory abnormalities in panic disorder remains unclear. The authors investigated the breath-by-breath complexity of respiration dynamics in panic disorder. METHOD: Respiratory physiology was assessed in 40 patients with panic disorder and 31 healthy comparison subjects by using a breath-by-breath stationary system for testing cardiorespiratory function. Irregularity in the breathing pattern was determined by applying the approximate entropy index, which is an indicator of the irregularity and the "disorder" of the measure.
RESULTS: The patients with panic disorder showed significantly higher approximate entropy indexes than the healthy subjects for the measured respiratory parameters. Sighs contributed to the irregularity of breathing patterns but did not account for all the differences in approximate entropy between the patients with panic disorder and the comparison subjects. Anxiety state, severity of illness, and somatic and individual variables such as participation in sports and cigarette smoking did not seem to influence the results.
CONCLUSIONS: Patients with panic disorder showed greater entropy in baseline respiratory patterns, indicating higher levels of irregularity and complexity in their respiratory function. Greater respiratory entropy could be a factor in vulnerability to panic attacks
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