216 research outputs found
9. März 1916
No full textStadtarchiv Solingen, Bergische Arbeiterstimme 9. März 1916 Die Beyenburger Munition AG Hindrich und Auffermann vermeldet einen Millionengewinn Kriegsgewinne der Rüstungsindustrie. Wie alle Unternehmungen der Kriegsindustrie, haben auch die Munitionsmaterial- und Metallwerke Hindrich u[nd] Auffermann A.-G. in Beyenburg bei Barmen Riesengewinne zu verzeichnen. Das erste Geschäfts- halbjahr 1915/16 brachte einen Reingewinn von 1,1 Millionen Mark, wobei die Anteile, Abschreibungen u..
Idiotype vaccination using dendritic cells after autologous peripheral blood progenitor cell transplantation for multiple myeloma
No full textAbstractThe idiotype (Id) determinants on the multiple myeloma immunoglobulin can serve as tumor-specific antigens. An anti-Id immune response may stem the growth of the malignant clone. We report on 26 patients treated at our institution with high-dose chemotherapy and peripheral blood progenitor cell transplantation (PBPCT) and vaccinated with the Id protein. The patients received chemotherapy and PBPCT to establish a minimal residual disease state. After high-dose therapy, the patients received a series of monthly immunizations consisting of 2 intravenous infusions of dendritic cells (DCs) pulsed with either Id protein or Id coupled with keyhole limpet hemocyanin (KLH) as an immunogenic carrier protein, followed by subcutaneous boosts of Id-KLH conjugates. DCs were obtained in all patients from a leukapheresis product 3 to 9 months after PBPCT. Patients were observed for toxicity, immune responses, and tumor status. The DC infusions and the administration of Id-KLH boosts were well tolerated, with patients experiencing only minor and transient side effects. Of the patients, 24 of 26 generated a KLH-specific cellular proliferative immune response. Only 4 patients developed an Id-specific proliferative immune response. Three of these immune responders were in complete remission at the time of vaccination. A total of 17 patients are alive at a median follow-up of 30 months after transplantation. Id vaccination with autologous DCs is feasible for myeloma patients after transplantation. Id-specific cellular responses can be induced in patients who are in complete remission. Further studies are needed to increase the rate of anti-Id immune responses in patients who do not achieve complete remission.Biol Blood Marrow Transplant 2000;6(6):621-7
Hydrogen dynamics in heavy alkali metal hydrides obtained through inelastic neutron scattering
No full textInelastic neutron scattering spectra from polycrystalline NaH, KH, RbH and CsH, measured at low temperature in the energy transfer range 3 meV < E < 500 meV, are reported. From the medium-energy regions, coinciding with the optical phonon bands, accurate hydrogen-projected densities of phonon states are extracted and compared to ab initio lattice dynamics results. The overall agreement is very good. Further lattice dynamics calculations, based on a pairwise Born–Mayer semi-empirical potential scheme, were also performed, providing only limited and qualitative agreement with the experimental data. In conclusion, incoherent inelastic neutron spectroscopy proves to be a stringent validation tool for lattice dynamics simulations of H-containing materials.Fil: Auffermann, G.. Max Planck Institut fur Chemische Physik fester Stoffe; AlemaniaFil: Barrera, Gustavo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Patagonia "San Juan Bosco". Facultad de Ciencias Naturales - Sede Comodoro. Departamento de Química; ArgentinaFil: Colognesi, D.. Istituto di Fisica Applicata ‘Nello Carrara’. Consiglio Nazionale delle Ricerche; ItaliaFil: Corradi, G.. Istituto di Fisica Applicata ‘Nello Carrara’. Consiglio Nazionale delle Ricerche; ItaliaFil: Ramirez Cuesta, A. J.. Rutherford Appleton Laboratory; Reino UnidoFil: Zoppi, M.. Istituto di Fisica Applicata ‘Nello Carrara’. Consiglio Nazionale delle Ricerche; Itali
Hochdrucksynthese und Kristallstruktur von YbH2.67
No full textYtterbiumhydrides can be synthesized by reaction of ytterbium metal in hydrogen atmosphere above 600 K. The experiments were carried out in the pressure range from 200 to 3200 bar. X-ray investigations on powdered samples and elastic neutron diffraction experiments on deuterated compounds led to a complete structure determination. YbH2.67 is obtained at reaction pressures of 200, 1400 und 3200 bar. In contrast to reports in literature the deuterides crystallize with trigonal symmetry (P (3) over bar 1m, a = 6.344(1) Angstrom, c = 9.002(1) Angstrom, Z = 9) and not in the cubic crystal system. The composition YbD2.67 was additionally checked by chemical analysis. The crystal structure can be described as a close packing of ytterbium atoms (stacking sequence ...ABC...) in which all tetrahedral holes and 2/3 of the octahedral holes are occupied in an ordered manner by hydrogen. Magnetic susceptibility measurements are in agreement with literature data
Hochdrucksynthese und Struktur von Rb2PtH6 und Cs2PtH6, ternären Hydriden mit K2PtCl6-Struktur
No full textTernary complex transition metal deuterides: Structure determination, investigations of the reaction mechanisms and phase transition studies
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Hochdrucksynthese und Struktur von Rb<sub>2</sub>PtH<sub>6</sub> und Cs<sub>2</sub>PtH<sub>6</sub>, ternaeren Hydriden mit K<sub>2</sub>PtCl<sub>6</sub> - Struktur
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