1,557 research outputs found
The Wide Band Spectral Analysis: A New Insight Into Modulation of Blood Pressure, Heart Rate and Baroreflex Sensitivity
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Power Spectra of Blood Pressure in Normotensive and Spontaneously Hypertensive Rats: Relationship with Sympathetic Cardiovascular Control
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Spontaneous Baroreflex Sensitivity: From the Cardiovascular Laboratory to Patient's Bedside
No full textDynamic adaptation of cardiac baroreflex sensitivity to prolonged exposure to microgravity: data from a 16-day spaceflight
No full textDi Rienzo M, Castiglioni P, Iellamo F, Volterrani M, Pagani M, Mancia G, Karemaker JM, Parati G. Dynamic adaptation of cardiac baroreflex sensitivity to prolonged exposure to microgravity: data from a 16-day spaceflight. J Appl Physiol 105: 1569-1575, 2008. First published August 28, 2008; doi:10.1152/japplphysiol.90625.2008.-This study explored the process of arterial baroreflex adaptation to microgravity, starting from the first day of flight, during the 16-day STS-107 Columbia Space Shuttle mission. Continuous blood pressure (BP), ECG, and respiratory frequency were collected in four astronauts on ground (baseline) and during flight at days 0-1, 6-7, and 12-13, both at rest and during moderate exercise (75 W) on a cycle ergometer. Sensitivity of the baroreflex heart rate control (BRS) was assessed by sequence and spectral alpha methods. Baroreflex effectiveness index (BEI); low-frequency (LF) power and high-frequency (HF) power of systolic BP (SBP), diastolic BP (DBP), and R-R interval (RRI); the RRI LF/HF ratio; and the RRI root mean square of successive differences (RMSSD) index were also estimated. We found that, at rest, BRS increased in early flight phase, compared with baseline (means +/- SE: 18.3 +/- 3.4 vs. 10.4 +/- 1.2 ms/mmHg; P < 0.05), and it tended to return to baseline in subsequent days. During exercise, BRS was lower than at rest, without differences between preflight and in-flight values. At rest, in the early flight phase, RMSSD and RRI HF power increased (P < 0.05) compared with baseline, whereas LF powers of SBP and DBP decreased. No statistical difference was found in these parameters during exercise before vs. during flight. These findings demonstrate that heart rate baroreflex sensitivity and markers of cardiac vagal modulation are enhanced during early exposure to microgravity, likely because of the blood centralization, and return to baseline values in subsequent flight phases, possibly because of the fluid loss. No deconditioning seems to occur in the baroreflex control of the heart
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
No full text Page H377–H383: G. Bertinieri, M. DiRienzo, A. Cavallazzi, A. U. Ferrari, A. Pedotti, and G. Mancia. “Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats.” Page H380: Table 3 should appear as the following: (See PDF) </jats:p
Different effects of antihypertensive regimens based on fosinopril or hydrochlorothiazide with or without lipid lowering by pravastatin on progression of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a randomized double-blind trial.
No full text1. Stroke. 2004 Dec;35(12):2807-12. Epub 2004 Oct 28.
Different effects of antihypertensive regimens based on fosinopril or
hydrochlorothiazide with or without lipid lowering by pravastatin on progression
of asymptomatic carotid atherosclerosis: principal results of PHYLLIS--a
randomized double-blind trial.
Zanchetti A, Crepaldi G, Bond MG, Gallus G, Veglia F, Mancia G, Ventura A, Baggio
G, Sampieri L, Rubba P, Sperti G, Magni A; PHYLLIS Investigators.
Istituto Auxologico Italiano, Ospedale Maggiore, University of Milan, Italy.
[email protected]
BACKGROUND AND PURPOSE: The Plaque Hypertension Lipid-Lowering Italian Study
(PHYLLIS) tested whether (1) the angiotensin-converting enzyme (ACE) inhibitor
fosinopril (20 mg per day) was more effective on carotid atherosclerosis
progression than the diuretic hydrochlorothiazide (25 mg per day), (2)
pravastatin (40 mg per day) was more effective than placebo when added to either
hydrochlorothiazide or fosinopril, and (3) there were additive effects of ACE
inhibitor and lipid-lowering therapies.
METHODS: A total of 508 hypertensive, hypercholesterolemic patients with
asymptomatic carotid atherosclerosis were randomized to: (A) hydrochlorothiazide;
(B) fosinopril; (C) hydrochlorothiazide plus pravastatin; and (D) fosinopril plus
pravastatin, and followed up blindly for 2.6 years. B-Mode carotid scans were
performed yearly by certified sonographers in 13 hospitals and read centrally.
Corrections for drift were calculated from readings repeated at study end.
Primary outcome was change in mean maximum intima-media thickness of far and near
walls of common carotids and bifurcations bilaterally (CBM(max)).
RESULTS: CBM(max) significantly progressed (0.010+/-0.004 mm per year; P=0.01) in
group A (hydrochlorothiazide alone) but not in groups B, C, and D. CBM(max)
changes in groups B, C, and D were significantly different from changes in group
A. Changes in group A were concentrated at the bifurcations. "Clinic" and
"ambulatory" blood pressure reductions were not significantly different between
groups, but total and low-density lipoprotein cholesterol decreased by
approximately 1 mmol/L in groups C and D.
CONCLUSIONS: Progression of carotid atherosclerosis occurred with
hydrochlorothiazide but not with fosinopril. Progression could also be avoided by
associating pravastatin with hydrochlorothiazide.
PMID: 15514192 [PubMed - indexed for MEDLINE
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
No full text Page H377–H383: G. Bertinieri, M. DiRienzo, A. Cavallazzi, A. U. Ferrari, A. Pedotti, and G. Mancia. “Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats.” Page H380: Table 3 should appear as the following: (See PDF) </jats:p
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