1,701 research outputs found
Basic symptoms and the prediction of first-episode psychosis
No full textRecent focus on early detection and intervention in psychosis has renewed interest in subtle psychopathology beyond positive and negative symptoms. Such self-experienced sub-clinical disturbances are described in detail by the basic symptom concept. This review will give an introduction into the concept of basic symptoms and describe the development of the current instruments for their assessment, the Schizophrenia Proneness Instrument, Adult (SPI-A) and Child and Youth version (SPI-CY), as well as of the two at-risk criteria: the at-risk criterion Cognitive-Perceptive Basic Symptoms (COPER) and the high-risk criterion Cognitive Disturbances (COGDIS). Further, an overview of prospective studies using both or either basic symptom criteria and transition rates related to these will be given, and the potential benefit of combining ultra-high risk criteria, particularly attenuated psychotic symptoms, and basic symptom criteria will be discussed. Finally, their prevalence in psychosis patients, i.e. the sensitivity, as well as in general population samples will be described. It is concluded that both COPER and COGDIS are able to identify subjects at a high risk of developing psychosis. Further, they appear to be sufficiently frequent prior to onset of the first psychotic episode as well as sufficiently rare in persons of general population to be considered as valuable for an early detection of psychosis
What percentage of people in the general population satisfies the current clinical at-risk criteria of psychosis?
No full textThe clinical validity of at-risk criteria of psychosis had been questioned based on epidemiological studies that have reported much higher prevalence and annual incidence rates of psychotic-like experiences (PLEs as assessed by either self rating questionnaires or layperson interviews) in the general population than of the clinical phenotype of psychotic disorders (van Os et al., 2009). Thus, it is unclear whether “current at-risk criteria reflect behaviors so common among adolescents and young adults that a valid distinction between ill and non-ill persons is difficult” (Carpenter, 2009). We therefore assessed the 3-month prevalence of at-risk criteria by means of telephone interviews in a randomly drawn general population sample from the at-risk age segment (age 16–35 years) in the Canton Bern, Switzerland. Eighty-five of 102 subjects had valid phone numbers, 21 of these subjects refused (although 6 of them signaled willingness to participate at a later time), 4 could not be contacted. Sixty subjects (71% of the enrollment fraction) participated. Two participants met exclusion criteria (one for being psychotic, one for lack of language skills).
Twenty-two at-risk symptoms were assessed for their prevalence and severity within the 3 months prior to the interview by trained clinical raters using (i) the Structured Interview for Prodromal Syndromes (SIPS; Miller et al., 2002) for the evaluation of 5 attenuated psychotic and 3 brief limited intermittent psychotic symptoms (APS, BLIPS) as well as state-trait criteria of the ultra-high-risk (UHR) criteria and (ii) the Schizophrenia Proneness Instrument, Adult version (SPI-A; Schultze-Lutter et al., 2007) for the evaluation of the 14 basic symptoms included in COPER and COGDIS (Schultze-Lutter et al., 2008). Further, psychiatric axis I diagnoses were assessed by means of the Mini-International Neuropsychiatric Interview, M.I.N.I. (Sheehan et al., 1998), and psychosocial functioning by the Scale of Occupational and Functional Assessment (SOFAS; APA, 1994). All interviewees felt ‘rather’ or ‘very’ comfortable with the interview.
Of the 58 included subjects, only 1 (2%) fulfilled APS criteria by reporting the attenuated, non-delusional idea of his mind being literally read by others at a frequency of 2–3 times a week that had newly occurred 6 weeks ago. BLIPS, COPER, COGDIS or state-trait UHR criteria were not reported. Yet, twelve subjects (21%) described sub-threshold at-risk symptoms: 7 (12%) reported APS relevant symptoms but did not meet time/frequency criteria of APS, and 9 (16%) reported COPER and/or COGDIS relevant basic symptoms but at an insufficient frequency or as a trait lacking increase in severity; 4 of these 12 subjects reported both sub-threshold APS and sub-threshold basic symptoms. Table 1 displays type and frequency of the sub-threshold at-risk symptoms
Independent Component Analysis of normal and abnormal rhythm in Twin pregnancies
No full textWe investigated the utility of ICA for evaluation of fetal rhythm in five
uncomplicated twin pregnancies and in five twin pregnancies complicated by fetal arrhythmia. Using objective and subjective criteria, we sought to determine how the signal-to-noise ratio, signal fidelity and interference rejection are affected when synthesizing the fetal signal using all the signal containing ICA components (rank-p ICA) versus using the single dominant component (rank-1 ICA). The signal of each fetus was most commonly distributed over 1 or 2 ICA components, as previously observed in studies of singleton pregnancies; however, in 8 of 26 (31%) cases the signal of each fetus
was distributed over 3, 4 or even 5 ICA components. Rank-1 ICA provided the highest SNR and interference rejection, but at the cost of reduced signal fidelity. Our results corroborate that in twin pregnancies, including twin pregnancies complicated by fetal arrhythmia, rank-1 ICA is very effective in isolating the
QRS complexes of each fetus; however, it has some limitations when used for fetal rhythm evaluation due to signal distortion. Occasionally, rank-1 ICA completely separates the P-wave and the T-wave from the QRS complex, thus requiring the mixing of several ICA components to achieve acceptable signal fidelity
Unacknowledged Health Benefits Of Genetically Modified Food - Salmon And Heart Disease Deaths
No full textRandall Lutter and Katherine Tuckerargue that the marketing of GM salmon will lower salmon prices and increase consumption of salmon, an exceptionally good source of omega-3 fatty acids linked to lower risk of heart disease.The authors estimateestimate that the resulting increase in omega-3 intake will prevent between 600 and 2600 deaths per year in the U.S.Environment, Health and Safety
Determination of dead-layer variation in HPGe detectors
No full textThe dead-layer uniformity of the top surface of two high purity germanium detectors has been studied using a novel automated scanning set-up that allows a fine-grained topography of a detector's top and lateral surfaces. Comparisons between measurements and Monte Carlo simulations allowed implementation of a dead-layer variation into the detector model, which reproduces the measurements results. The effect of the non-uniform dead-layer on activity determinations based on low-energy gamma-rays (i.e. below 100 key) has been determined to be of the order of 10% or more. (C) 2013 Elsevier Ltd. All rights reserved
Underground gamma-ray measurements of radium isotopes from hydrothermal plumes in the deep Pacific Ocean
No full text© The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hult, M., Charette, M., Lutter, G., Marissens, G., Henderson, P., Sobiech-Matura, K., & Simgen, H. Underground gamma-ray measurements of radium isotopes from hydrothermal plumes in the deep Pacific Ocean. Applied Radiation and Isotopes, 153, (2019): 108831, doi:10.1016/j.apradiso.2019.108831.The radium isotopes 226Ra and 228Ra can provide important data on the dynamics of deep-sea hydrothermal plumes that travel the oceans for decades and have great impact on the ocean chemistry. This study focuses on parameters important for obtaining low detection limits for 228Ra using gamma-ray spectrometry. It is present at mBq-levels in samples collected during the US GEOTRACES 2013 cruise to the Southeast Pacific Ocean.The work of the HADES-staff of Euridice at SCK•CEN is gratefully acknowledged. We are most grateful to Dr. Faidra Tzika for her work in the precursor to this project. Many thanks to Heiko Stroh for quality control and measurements in HADES. This research was supported in part by grants from the U.S. National Science Foundation, Ocean Sciences division (OCE-1232669 and OCE-1736277)
Validation of TOPAS MC for modelling the efficiency of an extended-range coaxial p-type HPGe detector
No full textTOPAS MC software was used to model the efficiency of a coaxial p-type HPGe detector, type GX9023 from Canberra. The model was validated by comparing experimental efficiencies with efficiencies calculated by TOPAS MC simulations. Three different geometries of radionuclide sources, placed at different heights from the detector endcap, were used to validate the model. The imposed criteria of 5% relative difference was met for a range of radionuclides and gamma-ray energies. As a result, the created detector model with TOPAS MC was considered validated.The research was conducted under a PhD grant at Hasselt University. This work also received support from the open access scheme EUFRAT at the European Commission’s Joint Research Centre in Geel, Belgium. The author would also like to thank the developer team of TOPAS MC for the special licence allowing the use of TOPAS MC for gamma-ray spec-trometry application
The adoption of lotteries in the United States, 1964 - 2007. A model of conditional and time-dynamical diffusion
No full textThe paper examines the determinants of the diffusion of state lotteries as a process of policy innovation. After more than 100 years of prohibition, U.S. states began to establish lotteries in the 1960s. The article uses statistical event history analysis to show that the adoption and diffusion of state lotteries depends on fiscal, political, and regional factors of competition as well as on normative factors of social legitimization. The article develops two further arguments, first by discussing an advanced model of regional diffusion that views the regional effect as being dependent on the ideologicalinstitutional context and second by analyzing time dynamics in the diffusion process to show how initial explanatory factors change over time. In general, the findings point to the institutional environment as a factor influencing the diffusion of organizations. -- Der Aufsatz beschäftigt sich mit den Determinanten der Diffusion staatlicher Lotterien als Beispiel einer politischen Innovation. Nach einer Verbotszeit von mehr als einhundert Jahren führten US-Bundesstaaten Lotterien ab den 1960er-Jahren schrittweise wieder ein. Anhand von statistischen Ereignisdatenanalysen zeigt der Beitrag, dass der Diffusionsprozess von fiskalischen, politischen und regionalen Faktoren ebenso wie von normativen Faktoren der sozialen Legitimierung abhängt. Der Aufsatz stellt zwei weitere Aspekte heraus, die empirisch demonstriert werden: Zum einen wird ein erweitertes regionales Diffusionsmodell diskutiert, das die räumliche Ausbreitung in Abhängigkeit zur ideologischen Struktur angrenzender Staaten erfasst; zum anderen wird die zeitliche Dynamik des Prozesses modelliert. Hierfür ist der soziologische Neo-Institutionalismus der theoretische Bezugspunkt, und es wird angenommen, dass mit zunehmender Dauer des Diffusionsprozesses die ursprünglichen Kausalfaktoren ihre Erklärungskraft zugunsten eines Bedeutungsgewinns von Legitimitätsaspekten verlieren. Die Ergebnisse dokumentieren isomorphische Adaptionsprozesse und in organisationsökologischer Hinsicht die Bedeutung institutioneller Umwelten für die Ausbreitung von Organisationen.
Lutter contre les discriminations, Sous la direction de Daniel Borrillo, 2003. Race politics in Britain and France : ideas and policymaking since the 1960s, Erik Bleich, 2003
No full textHargreaves Alec. G. Lutter contre les discriminations, Sous la direction de Daniel Borrillo, 2003. Race politics in Britain and France : ideas and policymaking since the 1960s, Erik Bleich, 2003. In: Hommes et Migrations, n°1246, Novembre-décembre 2003. France-USA : agir contre la discrimination. II – Méthodes et pratiques. pp. 132-134
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