1,721,176 research outputs found
Pharmaceutical composition of [(3-hydroxy-4 -pyron-2-yl) methyl] -amine derivatives and DNA demethylating agents and their use as anti-neoplastic drugs
No full textThe present invention concerns pharmaceutical compositions comprising compounds with general formula I or polyalkyl-bis- maltolic molecules and in particular derivatives of [(3-hydroxy-4- pyron-2-yl)methyl]-amine in combination with DNA demethylating agents as anti-neoplastic drugs. In particular, for the preparation of a medicament for the treatment of neoplastic pathologies
DERIVATIVES OF [(3-HYDROXY-4-PYRON-2-YL)-METHYL]-AMINE AND USE THEREOF AS ANTI-NEOPLASTIC DRUGS
No full textDERIVATI DI [(3-IDROSSI-4-PIRON-2-IL)METIL]-AMINA E LORO USO COME FARMACI ANTI-NEOPLASTICI
No full textDerivative of [(3-hydroxy-4-pyron-2-yl)-methyl]-amine and use thereof as anti-neoplastic drugs
No full textThe present invention relates to compounds heaving general formula (I), i.e. poly-alkyl-bis-maltolic molecules and in particular to derivates of [(3-hydroxy-4-pyron-2-yl)methyl]-amine and pharmaceutically accetable salts thereof, and to the use thereof as anti-neoplastic drugs, in particular, for a preparation of a medicament for the treatment of neoplastic disease
Combination of light and Ru(II) polypyridyl complexes: Recent advances in the development of new anticancer drugs
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N,N′-bis[(3-hydroxy-4(4H)-oxypyran-2-yl)methyl]-N,N′-dimethylethylene-1,2-diammonium tetrachloridoplatinate(II) dihydrate
No full textThe title compound (C16H22N2O 6)[PtCl4]·2H2O, shows antiproliferative activity in eight tumor cell lines. The asymmetric unit consists of one solvent water molecule on a general position, and one half of each of the polyammonium cation and the tetrachloridoplatinate(II) anion, both of them located on centers of inversion. In the crystal, the cations are connected via hydrogen bonding between the carbonyl O atoms and the hydroxyl H atoms into zigzag chains that elongate in the c-axis direction. In addition, the carbonyl O atom is hydrogen-bonded to the water molecule which, in turn, interacts with the [PtCl4]2- anion. Finally, the chains are linked by N-H +⋯Cl interactions into a three-dimensional network
Chimica. Principi generali con esercizi
No full textUn libro realizzato come testo per il primo corso di chimica presente nei vari Corsi di Laurea del nostro sistema universitario. Sono trattati i principi generali alla base della chimica che devono essere bagaglio imprescindibile per uno studente che affronta un qualsiasi percorso di laurea scientifica dal futuro chimico al biologo, dal geologo al biotecnologo, dal nutrizionista al medico, dall’ingegnere al farmacista, dall’agronomo al fisico e così via. Ad integrazione di questi principi, e per facilitare la verifica da parte dello studente della comprensione degli argomenti trattati, sono stati inseriti alla fine di ogni capitolo sia
un paragrafo concernente gli obiettivi minimi che dovrebbero essere acquisiti sia una serie di domande di autovalutazione con le quali lo studente può valutare il proprio grado di preparazione. Nel libro è inclusa la stechiometria, cioè quel ramo della chimica che si occupa delle relazioni quantitative nelle trasformazioni chimiche, necessaria per una corretta comprensione di molti degli argomenti trattati e per la loro applicazione reale. Questa è stata sviluppata inserendo, nei capitoli interessati, un’ampia casistica per la risoluzione guidata degli esercizi e una serie di esercizi non risolti per i quali sono state riportate le soluzioni a fine testo. La presenza della parte stechiometrica permette al libro di essere adottato come testo
unico in qualsiasi primo corso di chimica di livello universitario
2,5-Bis[2-({bis[3-(dimethylazaniumyl)propyl]azaniumyl}methyl)phenyl]-1,3,4-oxadiazole hexakis(perchlorate) sesquihydrate
No full textIn the title hydrated salt, C36H66N8O6+·6ClO4−·1.5H2O, the asymmetric unit consists of a hexaprotonated [H6L]6+ cation, five perchlorate anions in general positions, two on twofold rotation axes (one of which is disordered), and two water molecules of crystallization in general positions, one of them disordered around a twofold crystallographic axis. In the [H6L]6+ cation, two strong intramolecular N—H...N hydrogen bonds occur, involving the N atoms of the oxadiazole ring as acceptors and the closest NH+ groups of each dipropylenetriamine unit. In the crystal, the [H6L]6+ cations form channels along the a-axis direction, in which the perchlorate counter-ions and the water molecules are lodged. The crystal packing features a network of N—H...O and O—H...O hydrogen bonds involving the NH+ groups of the [H6L]6+ cation, the perchlorate anions and the water molecules
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