5,118 research outputs found
Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease
No full textHuman herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease associations. A role for HHV-6A/B has been proposed in several autoimmune disorders (AD), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. The focus of this review is to discuss the above-mentioned AD associated with HHV-6 and the mechanisms proposed for HHV-6A/B-induced autoimmunity. HHV-6A/B could trigger autoimmunity by exposing high amounts of normally sequestered cell antigens, through lysis of infected cells. Another potential trigger is represented by molecular mimicry, with the synthesis of viral proteins that resemble cellular molecules, as a mechanism of immune escape. The virus could also induce aberrant expression of histocompatibility molecules thereby promoting the presentation of autoantigens. CD46-HHV-6A/B interaction is a new attractive mechanism proposed: HHV-6A/B (especially HHV-6A) could participate in neuroinflammation in the context of MS by promoting inflammatory processes through CD46 binding. Although HHV-6A/B has the ability to trigger all the above-mentioned mechanisms, more studies are required to fully elucidate the possible role of HHV-6A/B as a trigger of AD
Possible role of human herpesvirus 6 as a trigger of autoimmune disease
No full textHuman herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease associations. A role for HHV-6A/B has been proposed in several autoimmune disorders (AD), including multiple sclerosis (MS), autoimmune connective tissue diseases, and Hashimoto's thyroiditis. The focus of this review is to discuss the above-mentioned AD associated with HHV-6 and the mechanisms proposed for HHV-6A/B-induced autoimmunity. HHV-6A/B could trigger autoimmunity by exposing high amounts of normally sequestered cell antigens, through lysis of infected cells. Another potential trigger is represented by molecular mimicry, with the synthesis of viral proteins that resemble cellular molecules, as a mechanism of immune escape. The virus could also induce aberrant expression of histocompatibility molecules thereby promoting the presentation of autoantigens. CD46-HHV-6A/B interaction is a new attractive mechanism proposed: HHV-6A/B (especially HHV-6A) could participate in neuroinflammation in the context of MS by promoting inflammatory processes through CD46 binding. Although HHV-6A/B has the ability to trigger all the above-mentioned mechanisms, more studies are required to fully elucidate the possible role of HHV-6A/B as a trigger of AD. © 2013 Francesco Broccolo et al
Description of author Lisa Price\u27s hiking trip through the Hundred Mile Wilderne
No full textDescription of author Lisa Price\u27s hiking trip through the Hundred Mile Wilderness, the final section of the Appalachian Trail in Maine. Price, who has hiked the Appalachian Trail for four years, one section at a time, meets up with fellow hikers Noel and Caroline at Shaw\u27s Boarding House in Monson, and the three reach the summit of Mount Katahdin together
Conversatorio con Lisa Garforth=Conversation with Lisa Garforth
No full textJulia Ramírez-Blanco conversa con Lisa Garforth, autora del libro Green Utopias y especialista en utopías medioambientales. Con ella, hablamos acerca de las posibles maneras de definir las ecotopías, y cómo estas se manifiestan tanto en la literatura como en distintas formas de práctica social.Julia Ramírez-Blanco interviews Lisa Garforth, author of the book Green Utopias and specialist in environmental utopias. With her, we talk about the possible ways of defining ecotopias, and how they manifest themselves both in literature and in different forms of social practice.http://re-visiones.net/audio/Entrevista-Lisa-Garfoth.mp
An interview with Alfredo Falcone and Lisa Salvatore: RECOURSE and trifluridine/tipiracil in metastatic colorectal cancer
No full textProfessor Alfredo Falcone and Dr Lisa Salvatore speak to Roshaine Gunawardana, Managing Commissioning Editor: Professor Alfredo Falcone is the Director of the Department of Oncology and the Specialization School at the University Hospital of Pisa, Italy. He trained in Pisa and Genoa, Italy, and has held major positions in Italian oncology since 2000. He currently has more than 300 publications, including papers in peer-reviewed international and national journals, book chapters, and more than 600 abstracts of presentations to international and national conferences. The majority of his papers regard clinical and translational research, with a particular focus on metastatic colorectal cancer. Dr Lisa Salvatore is a medical oncologist in the Department of Translational Research and New Technologies in Medicine and Surgery at the University of Pisa. She has been an author on about 40 publications in major peer-reviewed publications and has made numerous presentations in national and international conferences. Her main interest is focused on clinical and translational research in metastatic colorectal cancer
RHM Author Interview: Dr. Lisa Melonçon, RHM Editor, Interviews Dr. Abby Dubisar and Sara Davis on Their Persuasion Brief, "Communicating Elective Sterilization: A Feminist Perspective"
No full textRHM Author Interview: Dr. Lisa Meloncon, RHM Editor, interviews Dr. Abby Dubisar and Sara Davis on Their Persuasion Brief, “Communicating Elective Sterilization: A Feminist Perspective.
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Q & A with Lisa Duggan
No full textLisa Duggan is a Professor in American Studies at New York University. She was chair of this year's plenary session, which was entitled “Lesbian, Counter, and Queer: New Directions in the Study of Femininity.” She is author of Sapphic Slashers: Sex, Violence, and American Modernity, which won the John Boswell Prize of the American Historical Association in 2001. Her new book, The End of Marriage: The War over the Future of State Sponsored Love, will be published by University of California Press
Preservation assessment of the collections at the Oregon State Library, Salem, Oregon: October 6, 7 & 8, 2009
No full textReport -- Appendix A. Documentation Images -- Appendix B. Resources -- Appendix C. Recommended Books, Collection Policy Resources, Organizations for Reference & Vendors for Supplies -- Appendix D. Cost Estimates.prepared by Lisa Duncan, Art Conservator, LLC.Title from PDF title page (viewed on February 8, 2023).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Includes bibliographical references.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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