1,721,041 research outputs found
Updates on coagulation testing
No full textSummary - This paper illustrates the difficulties of accurately assessing the coagulation profile due to the complexity of this system, which is strictly related to inflammatory conditions. Moreover, the classical interpretation of the blood coagulation cascade has been reviewed, and some new highlights pointed out. Currently, several tests are available to explore primary or secondary haemostasis as well as fibrinolysis. The decision to use a preliminary panel of tests readily accessible to veterinarians in practice is worthy. Tests included in the preliminary panel should give a basic interpretation in the several steps of coagulation with good sensitivity and specificity. Then, depending on the results obtained, more detailed assays could be used in order to characterize the defect or the exact deficiency in haemostasis
Leishmaniasis and tick borne diseases in dogs. Evaluation of the coagulation profile
No full textLeishmaniasis and tick borne diseases are disorders frequently detected in the Mediterranean area, and due to the increased movement of animals across Europe are increasingly recognized also in other countries. Moreover, the intermediate hosts of these pathogens (sandflies and ticks) are widely distributed in Europe due to climate changes over the last decades. A large program of research in tick borne diseases is currently under way and some aspects still remain to be explored in order to clarify the importance and spread of these disorders. In subclinical or asymptomatic dogs it is quite rare to detect involvement of the coagulation system. In clinically affected dogs, due both to the severe inflammation and immunological disarrangement, the hemostatic system is strongly solicited, cooperating in the disease progression, course and prognosis
Validation of an immunoturbidimetric D-dimer assay in canine citrated plasma
No full textD-dimer is a neoantigen formed when thrombin initiates the transformation of fibrinogen to fibrin; it is derived from plasmin digestion of cross-linked fibrin. In human medicine, the usefulness of this analyte in diagnosing disseminated intravascular coagulation (DIC) has been assessed in patients fulfilling the clini- cal and laboratory requirements for this disorder. In canine medicine, the use of D-dimer is relatively new. Detailed studies are needed to understand the relationship between D-dimer concentration in plasma and DIC status in dogs. We validated a D-dimer immunoturbidimetric assay (Tina-quant [a] D-Dimer, Boehringer Mannheim) in canine citrated plasma samples. Intra-assay and interassay variability (coefficient of variation) was 5.63% and 8.82%, respectively. The assay was linear, using 2 samples with low and high D-dimer concen- trations (r = .996 and .998). Accuracy was 102.2% and 95.7% based on a recovery study in which 2 samples were assessed. Reference values for D-dimer were established using 70 healthy dogs that were assessed clinically and evaluated on the basis of a complete laboratory workup. The reference range was set between 0.02 and 0.28 μg/mL (chi-square test for normal distribution, P > .05)
Evaluation of the main poisoning in dogs in the period 2005-2015. Focus on the prevalence, clinical pathologic findings and neurological signs
No full textTo evaluate the cases of poisoning in dogs in 15 years of activity of a 24h Veterinary Clinic located in Padua, Nothr Italy
Evaluation of the main poisoning in dogs in the period 2005-2015. Focus on the prevalence, clinical pathologic findings and neurological signs
No full textTo evaluate the cases of poisoning in dogs in 15 years of activity of a 24h Veterinary Clinic located in Padua, Nothr Italy
Computed tomographic adrenal gland quantification in canine adrenocorticotroph hormone-dependent hyperadrenocorticism
No full textWe conducted a retrospective study to determine whether multidetector computed tomography (CT) could be of value for adrenal gland assessment in dogs with pituitary-dependent hyperadrenocorticism. Adrenal gland attenuation and volume values of 49 dogs with hyperadrenocorticism were recorded and age, body weight, and gender were examined to determine if a relationship existed between these variables and adrenal gland morphology. There was not a statistically significant difference in mean X-ray attenuation of the left vs. right adrenal gland in normal dogs (35.3 +/- 6.1 HU), or in dogs with hyperadrenocorticism. The mean adrenal X-ray attenuation (+/- standard deviation [SD]) in dogs with microadenoma was 33.1 +/- 6.8 vs. 31.8 +/- 12.7 HU for dogs with macroadenoma, and these values were not statistically different. The mean volume of the left adrenal gland in normal dogs (0.59 +/- 0.17 cm3) was greater than that of the right adrenal gland (0.54 +/- 0.19 cm3) (P < 0.05). The mean CT volume (+/- SD) of the adrenal glands in dogs with microadenoma vs. macroadenoma were 1.60 +/- 1.25 vs. 2.88 +/- 1.60 cm3, respectively. There was no effect of age or gender on adrenal gland morphology or X-ray attenuation. The weight effect was the most important source of variation for the volume measurement in dogs with hyperadrenocorticism
Spontaneous acromegaly: A retrospective case control study in German shepherd dogs
No full textAcromegaly results from the overproduction of growth hormone in adulthood and is characterised by
overgrowth of soft tissue and/or bone as well as insulin resistance. There are few data indicating the risk
factors associated with this disease in dogs or its clinicopathological features and sequelae. The objective
of this retrospective study was to catalogue and assess these aspects of the disease in German shepherd
dogs (GSDs) which were found to be over-represented among acromegalic dogs attending two
veterinary referral clinics over a period of 7 years. Each acromegalic dog (AD) was compared with two
breed/age/sex matched controls.
Clinical signs of acromegaly included panting, polyuria/polydipsia, widened interdental spaces, weakness,
inspiratory stridor, macroglossia, weight gain, redundant skin folds, thick coat, exophthalmos and
mammary masses. Serum alkaline phosphatase, creatine-kinase, glucose, triglyceride, phosphate ion, and
‘calcium per phosphate product’ concentrations were significantly higher in acromegalic animals while
haemoglobin concentration, blood urea nitrogen, sodium and chloride ion concentrations, and urinary
specific gravity, osmolality and fractional excretion of phosphate were significantly lower. Although, in
the majority of cases clinicopathological abnormalities resolved following ovariohysterectomy, in one dog,
acromegalic signs abated and insulin-like growth factor-1 concentrations normalised only following the
surgical excision of mammary tumours carried out 2 months after ovariohysterectomy. The findings of
this study indicate that GSDs are predisposed to the development of acromegaly with a suspected inherited
susceptibility
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