55 research outputs found
The role of ivabradine in diastolic heart failure with preserved ejection fraction. A doppler-echocardiographic study
No full textBackground: Ivabradine (IVA) is effective in patients with coronary artery disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in reducing heart rate (HR) and improving the time of left ventricular (LV) diastolic filling. The aim of this study was to evaluate the effects of IVA added to conventional therapy on patients with diastolic heart failure (DHF) and preserved ejection fraction (HFpEF). Methods: We evaluated 25 patients with DHF in the New York Heart Association (NYHA) Class II-III and sinus rhythm. In these, IVA per os (5 mg/twice a day) was added to the conventional medical therapy and given for 12 weeks. Immediately before the beginning of IVA therapy and 3 months later, patients underwent echocardiographic evaluation by two-dimensional (2D) ultrasound and tissue Doppler imaging (TDI). The patterns of diastolic mitral inflow and pulmonary venous flow were recorded using 2D echocardiography, while the diastolic phase of mitral flow was recorded by TDI, from the lateral mitral annulus. Results: Three months after the addition of IVA to conventional treatment, HR significantly decreased in comparison to the baseline values. On the contrary, the echocardiographic indexes of LV diastolic dysfunction improved. Conclusions: These results testify that the addition of IVA to conventional therapy in patients with HFpEF can improve LV diastolic function evaluated by 2D and tissue Doppler-echocardiographic patterns. These Doppler-echocardiographic results match with the clinical improvement of patients evaluated
Resistant hypertension in elderly patient with nephropathy in primary and secondary care settings
No full textResistant hypertension is defined as a blood pressure above therapeutic goals, despite the concurrent use of three or more antihypertensive drugs of different pharmacological classes, and all being administered according to an optimum dosage schedule. The prevalence of resistant hypertension in the older people has not yet been exactly quantified. The updated available estimates deriving from some clinical trials report a prevalence of approximately 20-30% of all hypertensive patients. Advanced age seems to be an important risk factor in resistant forms of high blood pressure. Therefore this clinical condition may potentially increase in the coming years. Chronic kidney disease is the most frequent comorbidity associated with resistant hypertension and often leads to poor prognosis. The article describes a case report of an older subject with such a clinical condition suggesting diagnostic and therapeutic plan based on a rational strategy to control hypertension and the most recent knowledge reported in the medical literature
Post-necrotic left ventricular dysfunction in diabetes mellitus: effects of Trimetazidine
No full text5'-methylthioformycin, a new structural analog of 5'-methylthioadenosine: effect on the enzymes of polyamine metabolism
No full text[S-adenosyl(5')-3-methylthiopropylamine as substrate and inhibitor of S-adenosylmethionine lyase from rat liver]
No full text
Analogs of 5'-deoxy-5'-methylthioadenosine modified in the purine ring: new synthetic procedure and effect on 5'-methylthioadenosine phosphorylase
No full textQuel S. Giacomo (e altri dipinti) di Nicola Cacciapuoti a Monteforte
No full textAttraverso un attento studio di ricerca l’autore attribuisce i dipinti che sono nell’altare maggiore della Chiesa di San Nicola a Monteforte Irpino al pittore giuglianese Nicola Cacciapuoti, allievo del Solimena e di Domenico Antonio Vaccaro. In particolare egli evidenzia l’accostamento del Cacciapuoti, tra il 1742 e il 1748, anche allo stile di Francesco De Mura. Attraverso un’analisi stilistica ed iconografica dei dipinti, emerge la figura di Nicola Cacciapuoti, di considerevole spessore culturale e protagonista nell’ambito della pittura della prima metà del Settecento nel Meridione. Il lavoro contribuisce a far luce su un pittore sinora ancora non sufficientemente conosciuto ed ap prezzato come merita.Through a careful research study, the author attributes the paintings that are in the high altar of the Church of San Nicola in Monteforte Irpino to the Giugliano’s painter Nicola Cacciapuoti, a pupil of Solimena and Domenico Antonio Vaccaro. In particular, he highlights the combination of Cacciapuoti, between 1742 and 1748, with the style of Francesco De Mura. Through a stylistic and iconographic analysis of the paintings, the considerable cultural value of Nicola Cacciapuoti emerges as protagonist in the painting of the first half of the eighteenth century in the South Italy. The current study helps to shed light on a painter not yet sufficiently known and appreciated as he deserves
Erratum to: Effect of moderate red wine intake on cardiac prognosis after recent acute myocardial infarction of subjects with Type 2 diabetes mellitus (Diabetic Medicine, (2006), 23, 9, (974-981), 10.1111/j.1464-5491.2006.01886.x)
No full textIn an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola.In an article by Marfella et al, the author name C. Saron is incorrect and should be listed as C. Sardu. Therefore the correct author list is: R. Marfella, F. Cacciapuoti, M. Siniscalchi, F. C. Sasso, F. Marchese, F. Cinone, E. Musacchio, M. A. Marfella, L. Ruggiero, G. Chiorazzo, D. Liberti, G. Chiorazzo, G. F. Nicoletti, C. Sardu, F. D'Andrea, C. Ammendola, M. Verza and L. Coppola
- …
