570 research outputs found
From the 'Rescue of the Nation State' to the Emergence of European Spaces. EUIJ-Kansai Workshop on "New Research Horizons of the History of European Integration", May 10, 2008, Toyonaka (Osaka)
No full textThe aim of this paper is to make some contribution to the discussion on the future direction of the historical research on the European integration processes. What I intend to do here is, broadly, to link the contemporary European studies to the Historical studies, and concretely, to emphasise the transnational dimension of European integration. This exercise should be read as presenting my "wish list" to the Integration Historians
The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC
No full text主査：宮澤正顯 教授 学内授与番号：医第1396号
Hiroaki Kanemura, Hidetoshi Hayashi, Shuta Tomida, Junko Tanizaki, Shinichiro Suzuki, Yusuke Kawanaka, Asuka Tsuya, Yasushi Fukuda, Hiroyasu Kaneda, Keita Kudo, Takayuki Takahama, Ryosuke Imai, Koji Haratani, Yasutaka Chiba, Tomoyuki Otani, Akihiko Ito, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa "The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC" JTO Clinical and Research Reports, Volume 3, Issue 8, August 2022,
https://doi.org/10.1016/j.jtocrr.2022.100373 掲
The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC
No full text近畿大学Kindai University博士（医学）主査：宮澤正顯 教授 学内授与番号：医第1396号
Hiroaki Kanemura, Hidetoshi Hayashi, Shuta Tomida, Junko Tanizaki, Shinichiro Suzuki, Yusuke Kawanaka, Asuka Tsuya, Yasushi Fukuda, Hiroyasu Kaneda, Keita Kudo, Takayuki Takahama, Ryosuke Imai, Koji Haratani, Yasutaka Chiba, Tomoyuki Otani, Akihiko Ito, Kazuko Sakai, Kazuto Nishio, Kazuhiko Nakagawa "The Tumor Immune Microenvironment and Frameshift Neoantigen Load Determine Response to PD-L1 Blockade in Extensive-Stage SCLC" JTO Clinical and Research Reports, Volume 3, Issue 8, August 2022,
https://doi.org/10.1016/j.jtocrr.2022.100373 掲載doctoral thesi
A Case of Strangulated Bowel Obstruction Caused by Barbed Suture Following Laparoscopic Sacrocolpopexy
No full textA 63-year-old woman underwent laparoscopic sacrocolpopexy for pelvic organ prolapse. Four days postoperatively, she underwent an abdominal computed tomography scan because she developed a stomachache, and a strangulated bowel obstruction was suspected. The patient then underwent an emergency laparotomy which revealed strangulation of the small intestine caused by a band formed between the stump of a barbed suture and the mesentery. The strangulation was released by resecting the stump, and intestinal resection was not necessary. Nine days following the re-intervention, the patient was discharged from our hospital. As of four months after the surgery, she has not experienced any recurrence of pelvic organ prolapse or other postoperative complications. We need some ingenuity when using barbed suture in situations where the thread and the intestine come into contact
Gambaran Kyouiku Papa Yang Tercermin Pada Tokoh Ayah Dalam Drama Gekokujo Juken Karya Sutradara Ryosuke Fukuda
No full textKyouiku papa adalah suatu konsep pendidikan dimana ayah memiliki peran
dalam pengasuhan dan pendidikan anak. Para ayah tidak hanya melaksananakan
perannya sebagai pencari nafkah saja, namun ikut serta dalam mengurus pendidikan
anak. Tujuan dari penelitian ini adalah untuk mengetahui gambaran konsep kyouiku
papa yang tercermin pada tokoh Shinichi Sakurai dan Naoyasu Tokugawa.
Penelitian ini menggunakan metode deskriptif analisis. Pendekatan yang
digunakan adalah sosiologi sastra, Kyouiku papa oleh Fukasawa, teori tokoh dan
penokohan dan teori mise-en-scene untuk menganalisis data yang ditemukan.
Hasil penelitian ini menunjukkan bahwa tokoh Shinichi Sakurai dan
Naoyasu Tokugawa sangat memperhatikan pendidikan anaknya. Tidak hanya
berperan sebagai pencari nafkah bagi keluarga saja, namun sangat peduli terhadap
pendidikan dan pengasuhan anak. Hal tersebut terlihat dari ketertarikan dalam
mendidik dan mengasuh anaknya, seperti memiliki metode khusus yang dibuat
dalam mengasuh anaknya, memiliki harapan besar terhadap anaknya, namun
memberikan kebebasan anaknya untuk mengambil keputusa
SimpleBounce: A simple package for the false vacuum decay
No full textWe present SimpleBounce, a C++ package for finding the bounce solution for the false vacuum decay. This package is based on a flow equation which is proposed by the author R. Sato (2020) and solves Coleman–Glaser–Martin’s reduced problem (S. R. Coleman et al. 1978): the minimization problem of the kinetic energy while fixing the potential energy. The bounce configuration is obtained by a scale transformation of the solution of this problem. For models with 1–8 scalar field(s), the bounce action can be calculated with O(0.1) % accuracy in O(0.1) s. This package is available at http://github.com/rsato64/SimpleBounce
APPLICATION OF A MARKOV PROCESS TO A MECHANICAL MODEL OF GRANULAR MATERIALS (2)
No full textIn the previous paper the author proposed a mechanical model of particulate materials as aMarkov process and explained the concepts of the potential barrier and the potential slip planewhich are introduced in the proposed model. Furthermore, the strain of particulate materialswas defined by using the change of contact angles at the contact points of particles and the dis-continuous motion of particles.In this paper the results of shearing tests obtained by the modified triaxial apparatus whichis designed and constructed, and can generate three different principal stresses are presented.The results of numerical experiments which are carried out by using the proposed model arealso presented. From both results it is shown that the proposed model can versatilely follow themechanical behaviours of particulate materials such as sands with complicated stress paths include-ing the stress reverse and repeated loading.In the previous paper the author proposed a mechanical model of particulate materials as aMarkov process and explained the concepts of the potential barrier and the potential slip planewhich are introduced in the proposed model. Furthermore, the strain of particulate materialswas defined by using the change of contact angles at the contact points of particles and the dis-continuous motion of particles.In this paper the results of shearing tests obtained by the modified triaxial apparatus whichis designed and constructed, and can generate three different principal stresses are presented.The results of numerical experiments which are carried out by using the proposed model arealso presented. From both results it is shown that the proposed model can versatilely follow themechanical behaviours of particulate materials such as sands with complicated stress paths include-ing the stress reverse and repeated loading
Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing
No full textSummarySpinal and bulbar muscular atrophy (SBMA), a progressive degenerative disorder, is caused by a CAG/glutamine expansion in the androgen receptor (polyQ AR). Recent studies demonstrate that skeletal muscle is an important site of toxicity that contributes to the SBMA phenotype. Here, we sought to identify critical pathways altered in muscle that underlie disease manifestations in AR113Q mice. This led to the unanticipated identification of gene expression changes affecting regulators of carbohydrate metabolism, similar to those triggered by denervation. AR113Q muscle exhibits diminished glycolysis, altered mitochondria, and an impaired response to exercise. Strikingly, the expression of genes regulating muscle energy metabolism is rescued following peripheral polyQ AR gene silencing by antisense oligonucleotides (ASO), a therapeutic strategy that alleviates disease. Our data establish the occurrence of a metabolic imbalance in SBMA muscle triggered by peripheral expression of the polyQ AR and indicate that alterations in energy utilization contribute to non-neuronal disease manifestations
Peripheral Protein Quality Control as a Novel Drug Target for CFTR Stabilizer
No full textConformationally defective cystic fibrosis transmembrane conductance regulator (CFTR) including rescued ΔF508-CFTR is rapidly eliminated from the plasma membrane (PM) even in the presence of a CFTR corrector and potentiator, limiting the therapeutic effort of the combination therapy. CFTR elimination from the PM is determined by the conformation-dependent ubiquitination as a part of the peripheral quality control (PQC) mechanism. Recently, the molecular machineries responsible for the CFTR PQC mechanism which includes molecular chaperones and ubiquitination enzymes have been revealed. This review summarizes the molecular mechanism of the CFTR PQC and discusses the possibility that the peripheral ubiquitination mechanism becomes a novel drug target to develop the CFTR stabilizer as a novel class of CFTR modulator
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