329,342 research outputs found
Kikuchi-Fujimoto disease complicated by peripheral neuropathy
No full textKikuchi-Fujimoto disease is a necrotizing lymphadenitis, mainly characterized by lymphadenopathy, fever, hepatosplenomegaly, nocturnal sweats, myalgia, weight loss, and arthralgia. Its diagnosis is most often based on lymph node biopsy. Differential diagnoses with several other diseases, e.g., malignant lymphoma, necrotizing lymphadenitis, and infective lymphadenopathies, may be challenging. Neurologic involvement is rarely reported in patients diagnosed with Kikuchi-Fujimoto disease. In this subset of patients, the great majority manifest signs involving the central nervous system. We present a 14-year-old boy with a severe form of Kikuchi-Fujimoto disease, complicated by peripheral neuropathy. This patient is interesting for both his age and his peculiar complication
The Kikuchi-Fujimoto Disease in Nigeria: A Case Report and Literature Review
No full textThe Kikuchi-Fujimoto is a rare, self-limiting disease, which is characterized by regional lymphadenopathy. It occurs worldwide with a higher prevalence among Asians and women below the age of forty years. We present 41-year-old Nigerian woman who was investigated extensively for unilateral left cervical lymphadenopathy. She was eventually diagnosed as having the Kikuchi-Fujimoto disease and was managed conservatively thereafter. We describe a case report and review of literature for better awareness of the disease amongst medical practitioners and pathologists in Africa
Kikuchi-Fujimoto disease complicated by peripheral neuropathy.
No full textKikuchi-Fujimoto disease is a necrotizing lymphadenitis, mainly characterized by lymphadenopathy, fever, hepatosplenomegaly, nocturnal sweats, myalgia, weight loss, and arthralgia. Its diagnosis is most often based on lymph node biopsy. Differential diagnoses with several other diseases, e.g., malignant lymphoma, necrotizing lymphadenitis, and infective lymphadenopathies, may be challenging. Neurologic involvement is rarely reported in patients diagnosed with Kikuchi-Fujimoto disease. In this subset of patients, the great majority manifest signs involving the central nervous system. We present a 14-year-old boy with a severe form of Kikuchi-Fujimoto disease, complicated by peripheral neuropathy. This patient is interesting for both his age and his peculiar complication
Kikuchi-Fujimoto`s Disease with Adult Onset Still`s Disease
No full textKikuchi-Fujimoto`s disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign and self-limiting disease. KFD are confused with systemic autoimmune disease as they present with localized lymphadenopathy, fever, fatigue, arthritis, leukopenia. Furthermore as KFD can occur associated with other autoimmune disease, we need to diagnose carefully. Here, we describe a case of 27-year-old female patient, diagnosed as KFD, who subsequently developed adult onset Still`s disesase (AOSD). As far as we know, this is the first case of KFD with AOSD in Korea.ope
Kikuchi-Fujimoto disease from eastern India
No full textKikuchi′s disease, a rare disorder which usually presents with fever painful lymphadenopathy, rash and arthritis, all of which are close mimickers of infective and immunological disorders. It is essentially a histopathological diagnosis and tests to rule out other connective tissue disorders or infective etiology must be undertaken. We present a series of two cases of kikuchi-fujimoto′s disease presenting primarily with lymphadenopathy and fever in all cases. The first is a case of generalized lymphadenopathy and the second case of kikuchi′s disease with SLE, a rare association. Lymph node excision biopsy and histopathology documented Kikuchi Fujimoto disease in above cases. All the cases improved on follow up and had no residual stigmata
Nonlinear input-normal realizations based on the differential eigenstructure of hankel operators
No full textThis paper investigates the differential eigenstructure of Hankel operators for nonlinear systems. First, it is proven that the variational system and the Hamiltonian extension with extended input and output spaces can be interpreted as the Gâteaux differential and its adjoint of a dynamical input-output system, respectively. Second, the Gâteaux differential is utilized to clarify the main result the differential eigenstructure of the nonlinear Hankel operator which is closely related to the Hankel norm of the original system. Third, a new characterization of the nonlinear extension of Hankel singular values are given based on the differential eigenstructure. Finally, a balancing procedure to obtain a new input-normal/output-diagonal realization is derived. The results in this paper thus provide new insights to the realization and balancing theory for nonlinear systems.
Articulatory effects of vowel context on fricatives: an MRI study
No full textMagnetic resonance imaging (MRI) is increasingly used in speech production research, particularly to obtain three-dimensional images of sustainable sounds such as fricatives or vowels. However, acoustic studies of fricatives [Shadle et al., Proc. ETRW, 193-196 (1996)] have shown that the spectral shape varies with vowel context, with the amount of variation depending on the fricative. This study, therefore, uses MRI to study the articulatory correlates of vowel context effects on fricatives. Two subjects (male French, female American English) for whom a large acoustic, aerodynamic, and articulatory database of fricatives already existed, were studied. Three different imaging methods were used that varied in acquisition time, image quality, and image extent: midsagittal turbo-flash (2 s), midsagittal spin-echo (15 s), and full coronal and axial spin-echo scans (approx. 2 min each). The subjects uttered the fricatives [f, theta, s, S] in vowel contexts [a, i, u]. Results indicate that not only are vowel context effects preserved in the longer duration images, they are often heightened. [f] showed the greatest variation in configuration with vowel context. Comparison to acoustic results and other MRI studies will be presented. [Work supported by ATR HIP Laboratories, while the first author was an invited researcher at ATR.]
A case of Kikuchi-Fujimoto disease misdiagnosed as Hodgkin's lymphoma: the importance of second opinion
No full textKikuchi-Fujimoto disease (KFD), a rare clinicopathological entity, is a benign and self-limiting disease. It was first described in 1972 by Kikuchi and Fujimoto in Japan independently KFD is prevalent in Asia, although it may be seen in wide geographical areas, including Turkey. It mainly affects young women. Cervical lymphadenopathy is the most prominent sign and should be differentiated from lymphoproliferative, autoimmune, and infectious diseases. We report on a 30-year-old female patient who was referred to our medical oncology unit for chemotherapy and/or radiotherapy with diagnosis of Hodgkin's lymphoma. Ultimately her diagnosis was corrected as KFD after second opinion of the pathology, specimens. We herein provide a brief review about KFD and the importance of second opinion of the pathology specimens
Enfermedad de Kikuchi-Fujimoto: presentación de un caso pediátrico
No full textLa enfermedad de Kikuchi-Fujimoto, o linfadenitis necrosante histiocítica, es una afección benigna, poco frecuente, generalmente de resolución espontánea, en un periodo de seis meses. La presentación
clínica característica incluye linfadenopatía cervical, leucopenia y síndrome febril prolongado. Se presenta con mayor frecuencia en mujeres asiáticas jóvenes y existen pocas descripciones de esta
enfermedad en la población pediátrica.
Frecuentemente simula linfadenitis tuberculosa, linfoma maligno, lupus eritematoso sistémico y muchas otras condiciones benignas y malignas. La etiología es desconocida; sin embargo, se ha sugerido un origen viral o autoinmunitario. Los hallazgos de laboratorio generalmente son inespecíficos, siendo los más frecuentes la leucopenia, el aumento de la sedimentación globular, la anemia y la presencia de anticuerpos antinucleares.
En vista de lo inespecífico de las manifestaciones clínicas y de laboratorio, el hallazgo histológico es lo que permite definir el diagnóstico. El diagnóstico temprano es importante, entre otras razones para evitar el uso inapropiado de antibióticos.
Se describe el caso de una paciente de 10 años, con síndrome febril prolongado y adenopatías cervicales secundarias a enfermedad de Kikuchi-Fujimoto
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