57,555 research outputs found
Usher syndrome associated with Fuchs’ heterochromic uveitis: a case report
No full textEce Turan-Vural, Banu Torun-Acar, Nejla Tükenmez, M Şahin Sevim, Bulent Buttanri, Suphi AcarOphthalmology Clinic, Haydarpasa Numune Education and Research Hospital, Istanbul, TurkeyAbstract: We report a case of Usher syndrome in association with unilateral Fuchs' heterochromic uveitis.Keywords: Fuchs’ heterochromic uveitis, Usher syndrome, deafness, blindnes
Urinary neopterin concentrations and T-cell subset data in HIV-1 infection
No full textReibnegger G, Fuchs D, Goedert JJ, et al. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 1990;68(1):43-48.We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression
Settling of finite-size particles in isotropically forced, homogeneous turbulence: interface-resolved simulations
No full textWe have simulated the gravity-induced settling of finite-size particles in a turbulent background flow which is forced in a statistically-stationary fashion. The simulations are accurately resolving the solid-fluid interface with the aid of an immersed boundary technique [1]. The parameters of the simulation are (apart from background turbulence) identical to those of reference [2], where particle clustering was observed at a Galileo number of 178 and a solid volume fraction of 0.005. In the present case, it is found that a relative turbulence intensity of 0.24 leads to the disappearance of the clusters; as a consequence, the increase in average particle settling velocity found in [2] also vanishes. [1] M. Uhlmann. An immersed boundary method with direct forcing for the simulation of particulate flows. J. Comput. Phys., 209(2):448–476, 2005. [2] M. Uhlmann and T. Doychev. Sedimentation of a dilute suspension of rigid spheres at intermediate Galileo numbers: the effect of clustering upon the particle motion. J. Fluid Mech., 752:310–348, 2014
Immunohistochemical analysis of iris biopsy specimens from patients with Fuchs' heterochromic cyclitis
No full textUsing immunohistochemical techniques, we analyzed iris biopsy specimens from eight patients with Fuchs' heterochromic cyclitis, seven patients with various other types of uveitis, and eight glaucoma patients without uveitis. No specific abnormalities related to Fuchs' heterochromic cyclitis could be detected. Four of the patients with Fuchs' heterochromic cyclitis and four of the patients with uveitis showed evidence of an inflammatory cell infiltrate, which was a mixture of interleukin-2 receptor-negative T helper and suppressor cells, B lymphocytes, and plasma cells. Only an occasional T lymphocyte could be seen in two of the patients without uveitis. The class II antigen HLA-DR was expressed on iris stromal cells in every patient in the Fuchs' heterochromic cyclitis group and uveitis group and in six of the patients in the nonuveitis group. In six of the Fuchs' heterochromic cyclitis patients, including two without immunohistochemical evidence of inflammatory cell infiltrate, histologic abnormalities were present on hematoxylin and eosin sections
UNUSUALLY COORDINATED PHOSPHORUS-COMPOUNDS .39. PHOSPHATRIAFULVENES - PHOSPHAALKENES WITH INVERSE ELECTRON-DENSITY
No full textFUCHS EPO, HEYDT H, REGITZ M, Schoeller W, BUSCH T. UNUSUALLY COORDINATED PHOSPHORUS-COMPOUNDS .39. PHOSPHATRIAFULVENES - PHOSPHAALKENES WITH INVERSE ELECTRON-DENSITY. TETRAHEDRON LETTERS. 1989;30(38):5111-5114
A new gene locus of Bordetella pertussis defines a novel family of prokaryotic transcriptional accessory proteins
No full textRecently, a novel type of regulatory mutation causing differential effects on the expression of virulence genes due to a slight overexpression of the RNA polymerase α subunit (RpoA) was found in Bordetella pertussis (N. H. Carbonetti, T. M. Fuchs, A. A. Patamawenu, T. J. Irish, H. Deppisch, and R. Gross, J. Bacteriol. 176:7267-7273, 1994). To gather information on the molecular events behind this phenomenon, we isolated suppressor mutants of the RpoA-overexpressing strains after random mutagenesis. Genetic characterization of these suppressor strains revealed the existence of at least three distinct groups of dominant alleles. Mutations occurred either in the rpoA locus itself, in the bvg locus, or in unknown gene loci. One mutant of the latter group was further characterized. By the introduction of a cosmid library containing genomic B. pertussis DNA into this suppressor strain, we isolated a cosmid which suppressed the phenotype of the suppressor strain, thus restoring the negative effect on transcription of the ptx and cya toxin genes. Mutagenesis of the cosmid with Tn5 led to the identification of the gene locus responsible for this phenomenon. Its DNA sequence revealed the presence of an open reading frame (ORF) consisting of 2,373 bp coding for a hypothetical 86-kDa protein with extensive sequence similarities to ORFs with not yet identified functions of Escherichia coli, Haemophilus influenzae, and Neisseria meningitidis. The new gene, termed tex, for toxin expression, seems to be an essential factor for B. pertussis, as it cannot be deleted from the bacterial chromosome. All members of this new protein family show significant sequence similarities with the mannitol repressor protein MtIR and with the presumptive RNA-binding domains of the Pnp and ribosomal S1 proteins of E. coli in their N- and C- terminal parts, respectively. These sequence similarities and the fact that the tex gene was isolated by virtue of its effects on gene expression in B. pertussis indicate that the members of this new protein family may play an important role in the transcription machinery of prokaryotic organisms
Immunohistochemical analysis of iris biopsy specimens from patients with Fuchs' heterochromic cyclitis
No full textUsing immunohistochemical techniques, we analyzed iris biopsy specimens from eight patients with Fuchs' heterochromic cyclitis, seven patients with various other types of uveitis, and eight glaucoma patients without uveitis. No specific abnormalities related to Fuchs' heterochromic cyclitis could be detected. Four of the patients with Fuchs' heterochromic cyclitis and four of the patients with uveitis showed evidence of an inflammatory cell infiltrate, which was a mixture of interleukin-2 receptor-negative T helper and suppressor cells, B lymphocytes, and plasma cells. Only an occasional T lymphocyte could be seen in two of the patients without uveitis. The class II antigen HLA-DR was expressed on iris stromal cells in every patient in the Fuchs' heterochromic cyclitis group and uveitis group and in six of the patients in the nonuveitis group. In six of the Fuchs' heterochromic cyclitis patients, including two without immunohistochemical evidence of inflammatory cell infiltrate, histologic abnormalities were present on hematoxylin and eosin sections
The Visible Vortex Interactive Analysis and Extraction of Vortices in Large Time-dependent Flow
No full textComputersimulation physikalischer und chemischer Prozesse sind ein essentielles Hilfsmittelzum Verständnis von Problemen aus dem Bereich der Strömungslehre geworden. Mit aktuellenSimulationspaketen ist es möglich für realistische Szenarien zeitabhängige Lösungenzu berechnen. Die berechneten Lösungen werden in großen Gitternetzen gespeichert, sindhäufig zeitabhängig und enthalten die multivariaten Ergebnisse der numerischen Simulation.Mit zunehmender Komplexität der Simulationsergebnisse entsteht die Notwendigkeitgeeignete Analyse- und Darstellungswerkzeuge zu verwenden, um aus den erzeugten Daten Erkenntnisse zu gewinnen und die gegebene Fragestellung lösen zu können. Dafür sindneue Methoden und Algorithmen notwendig um wichtige Teile der Daten zu extrahieren,wichtige Strukturen in der Strömung zu erkennen und das Strömungsverhalten interaktivanalysieren zu können.Das Hauptmotiv dieser Arbeit ist die Erweiterung vonWirbelkriterien auf zeitabhängigeLösungen und die Kombination dieser Wirbelkriterien mit den Methoden der interaktivenvisuellen Analyse. Um ein Verständnis für die Simulationsergebnisse zu entwickeln ist esnotwendig Attribute der Simulation miteinander vergleichen und mit größeren Strukturenwie Strömungswirbeln in Verbindung bringen zu können. Es wird gezeigt, wie automatischeWirbeldetektoren und interaktive Analyse kombiniert werden um sowohl Erkennung alsauch Analyse von Wirbelstrukturen zu verbessern.Indem klassische Wirbeldetektoren erweitert und in die visuelle Analyse integriert werden,ist es möglich die Auswirkung von Wirbeln auf wichtige Attribute der Flüssigkeit unddie Entwicklung der Strömung zu verstehen. Wir zeigen anhand von praktischen Beispielenaus dem Bereich der Motorentwicklung, dass Wirbel einen entscheidenden Einfluss aufanwendungskritische Variablen der Strömung haben können und demonstrieren wie interaktivevisuelle Analyse helfen kann diesen Einfluss einzuschätzen. Weiterhin besprechenwir wie zeitabhängige Größen in die Wirbelbestimmung einfließen können um die Qualitätder gefundenen Merkmale zu verbessern. - Computational simulation of physical and chemical processes has become an essential toolto tackle questions from the field of fluid dynamics. Using current simulation packagesit is possible to compute unsteady flow simulations for realistic scenarios. The resultingsolutions are stored in large to very large grids in 2D or 3D, frequently time-dependent,with multi-variate results from the numeric simulation. With increasing complexity ofsimulation results, powerful analysis and visualization tools are needed to make sense ofthe computed information and answer the question at hand. To do this we need newapproaches and algorithms to locate regions of interest, find important structures in theflow and analyze the behavior of the flow interactively.The main motives of this thesis are the extension of vortex detection criteria to unsteadyflow and the combination of vortex detectors with interactive visual analysis. To developan understanding for the simulation results it is necessary to compare attributes of thesimulation to each other and to be able to relate them to larger structures such as vortices.It is shown how automatic feature detection algorithms can be combined with interactiveanalysis techniques such that both detection and analysis benefit.By extending and integrating vortex detectors into the process of visual analysis, itbecomes possible to understand the impact of vortex structures on the development ofthe flow. Using real-world examples from the field of engine design we discuss how vortexstructures can have critical impact on the performance of a prototype. We illustrate howinteractive visual analysis can support prototype design and evaluation. Furthermore, weshow that taking the unsteady nature of the flow into account improves the quality of theextracted structures.EG Graphics Dissertation Onlin
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