1,721,304 research outputs found
Mechanical properties and surface reactivity in relationship to toxicity of new Ti-Cu based hard metals
No full textNanosized TiO2 is internalized by dorsal root ganglion cells and causes damage via apoptosis
Full text linkTitanium dioxide (TiO2) is widely used as ingredient in several products in the nanoform. TiO2-nanoparticles (NPs) are also currently studied for different medical applications. A large debate exists on possible adverse health effects related to their exposure. While there is some evidence of TiO2-NP central nervous system toxicity, their effects on peripheral neurons have been poorly explored. In this study we investigated the effects of TiO2-NPs on dorsal root ganglion (DRG) sensory neurons and satellite glial cells that may be reached by nanoparticles from the bloodstream. We found that TiO2-NPs are internalized in DRG cells and induce apoptosis in a dose dependent manner in both types of cells, ROS production and changes in expression of proinflammatory cytokine IL-1β. Furthermore, we found that the axonal retrograde transport is altered in neurons upon exposure to TiO2-NPs. Overall, the results indicate a potential neurotoxic effect of TiO2-NPs on DRG cells
Sulla applicabilità del principio di aspecificità a depressivi del sistema nervoso centrale
No full textManufactured nanoparticles : proprietà chimico-fisiche e potenziali rischi per la salute e per l'ambiente"
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Surface characterization of various silicas. A tentative correlation between the energy of adsorption sites and the different biological activities
No full textIn vitro cleavage by asbestos fibers of the fifth component of human complement through free-radical generation and kallicrein activation
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