1,774 research outputs found
Distribution ofnon-phosphorylated and phosphorylated neurofilament proteins in the spinal cord of an anuran amphibian during development and regeneration.
No full textslet-Like Clusters Derived from Mesenchymal Stem Cells in Wharton’s Jelly of the Human Umbilical Cord for Transplantation to Control Type 1 Diabetes.
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β-carotene as a novel adjuvant in the therapy with 5-FU of p53 deleted colon cancer cells
No full textColon cancer is one of the leading causes of cancer-related death worldwide. The main cause of failure in colon cancer therapy is represented by drug resistance in the course of treatment which has become very common. Despite recent therapeutic advancements, resistance to 5- Fluoruracil (5-FU) is still a major obstacle to successful treatments of this disease. Consequently, how to overcome 5-FU resistance is a key issue for cancer management. In order to study novel therapeutic approaches taking advantage from natural compounds showing anticancer effects we focused our interest on beta-carotene and its potential antiproliferative effects to overcome drug resistance. This compound is the most abundant carotenoid in the human diet and a well-known precursor of retinoids which, as regulator of cell proliferation and differentiation, has been shown to inhibit colon cancer progression [1]. In this study we assessed the potential role of beta-carotene as adjuvant of 5-FU in the treatment with 5-FU of p53 deleted colon cancer cells.
Our results led us to propose beta-carotene in combination with 5-FU as a promising cancer therapy by examining p53 profiles in tumors to yield a better clinical outcomes.
1. Lee NY, Kim Y, Kim YS, Shin JH, Rubin LP, Kim Y. β-Carotene exerts anti-colon cancer effects by regulating M2 macrophages and activated fibroblasts. J Nutr Biochem. 2020 Aug;82:108402. doi: 10.1016/j.jnutbio.2020.108402. Epub 2020 Apr 24. PMID: 32450500
Unexpected pregnancy and ovarian hyperstimulation syndrome following IVF cycle with all embryos frozen : a case report
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Determination of linear alkylbenzenesulfonates in modern sediments from core Zhu-9 and its significance
No full textArtificial interspecific hybridization between Macrobrachium species
Full text linkViable F-1 hybrids were obtained from crosses of female Macrobrachium nipponense and male Macrobrachium hainanense involving spermatophore transfer and artificial insemination. This represents the first successful known case of hybridization of two Macrobrachium species by means of artificial insemination. The hatching rate was over 90%. About 20-60% of newly hatched larvae metamorphosed to postlarvae. The morphological characteristics of the hybrids resembled a combination of features of both parents. Malate dehydrogenase (MDH) and esterase (EST) isozyme electrophoresis indicated parents and F-1 hybrids showed co-dominant expression of the paternal and maternal alleles controlling the isozymes and confirmed the hybridization. (C) 2004 Elsevier B.V. All rights reserved.Viable F-1 hybrids were obtained from crosses of female Macrobrachium nipponense and male Macrobrachium hainanense involving spermatophore transfer and artificial insemination. This represents the first successful known case of hybridization of two Macrobrachium species by means of artificial insemination. The hatching rate was over 90%. About 20-60% of newly hatched larvae metamorphosed to postlarvae. The morphological characteristics of the hybrids resembled a combination of features of both parents. Malate dehydrogenase (MDH) and esterase (EST) isozyme electrophoresis indicated parents and F-1 hybrids showed co-dominant expression of the paternal and maternal alleles controlling the isozymes and confirmed the hybridization. (C) 2004 Elsevier B.V. All rights reserved
Author's reply to comment on ""Biological removal of polychlorinated dibenzo-p-dioxins from incinerator fly ash by sphingomonas wittichii RW1"" by Rolf U. Halden
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