437 research outputs found
Asymptotic behavior of solutions to the conformal quotient equation
No full textWe classify all radial admissible solutions to the conformal quotient equation on the punctured Euclidean space and prove that an admissible solution to the conformal quotient equation with an isolated singular point is asymptotic to a radial solution. We also provide an alternative proof to obtain higher order expansion of solutions using analysis of the linearized operators. This dissertation is based on a preprint of the author [89].Ph. D.Includes bibliographical referencesIncludes vitaby Yunpeng Wan
The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference
No full textDu, Chao, Liu, Li, Liu, Yunpeng, Fu, Zhaohui (2020): The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference. Zootaxa 4810 (2): 351-360, DOI: https://doi.org/10.11646/zootaxa.4810.2.
FIG. 3 in The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference
No full textFIG. 3. Phylogenetic trees of 17 piciform species based on the nucleotide dataset inferred from Bayesian inference (a) and maximum likelihood (b). The numbers abutting branches refer to Bayesian posterior probabilities (BPP) and bootstrap support (BS). Halcyon pileata (Coraciiformes) was used to root the trees as an outgroup.Published as part of <i>Du, Chao, Liu, Li, Liu, Yunpeng & Fu, Zhaohui, 2020, The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference, pp. 351-360 in Zootaxa 4810 (2)</i> on page 356, DOI: 10.11646/zootaxa.4810.2.8, <a href="http://zenodo.org/record/4280803">http://zenodo.org/record/4280803</a>
FIG. 1 in The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference
No full textFIG. 1. Circular map of the J. torquilla mitogenome. The inner circle shows the GC content, which is calculated based on a window-sliding method. The outer circle shows the gene features, orange for rRNA, red for tRNA, and blue for CDS. Genes inside the circle (on the J strand) are transcribed clockwise, while the outsides (on the N strand) are transcribed counterclockwise.Published as part of Du, Chao, Liu, Li, Liu, Yunpeng & Fu, Zhaohui, 2020, The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference, pp. 351-360 in Zootaxa 4810 (2) on page 354, DOI: 10.11646/zootaxa.4810.2.8, http://zenodo.org/record/428080
FIG. 4 in The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference
No full textFIG. 4. Phylogenetic trees of 17 piciform species based on the amino acid dataset. The numbers abutting branches refer to Bayesian posterior probabilities (left) and ML bootstraps (right), ‾ not recovered. Branch lengths and topology are from the BI analysis. Halcyon pileata (Coraciiformes) was used to root the trees as an outgroup.Published as part of Du, Chao, Liu, Li, Liu, Yunpeng & Fu, Zhaohui, 2020, The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference, pp. 351-360 in Zootaxa 4810 (2) on page 358, DOI: 10.11646/zootaxa.4810.2.8, http://zenodo.org/record/428080
Supplemental_Material – Supplemental material for A nomogram based on a gene signature for predicting the prognosis of patients with head and neck squamous cell carcinoma
No full textSupplemental material, Supplemental_Material for A nomogram based on a gene signature for predicting the prognosis of patients with head and neck squamous cell carcinoma by Bowen Yang, Lingyu Fu, Shan Xu, Jiawen Xiao, Zhi Li and Yunpeng Liu in The International Journal of Biological Markers</p
FIG. 2 in The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference
No full textFIG. 2. Genetic distance within subfamily, between subfamily and family. Each boxplot represents the P distance based on the nucleotide and the amino acid datasets from 13 mitochondrial PCGs. Lower horizontal bar represents smallest observation, lower edge of rectangle represents 25 percentile, central bar within rectangle represents median, upper edge of rectangle represents 75 percentile, upper horizontal bar represents largest observation.Published as part of <i>Du, Chao, Liu, Li, Liu, Yunpeng & Fu, Zhaohui, 2020, The complete mitochondrial genome of the Eurasian wryneck Jynx torquilla (Aves Piciformes: Picidae) and its phylogenetic inference, pp. 351-360 in Zootaxa 4810 (2)</i> on page 356, DOI: 10.11646/zootaxa.4810.2.8, <a href="http://zenodo.org/record/4280803">http://zenodo.org/record/4280803</a>
Image_1_5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients.TIF
No full textAlthough the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU) is generally considered to directly kill cancer cells and exert immunostimulatory effects in advanced gastric cancer, accumulating evidence indicates that it upregulates the expression of PD-L1, a representative immune checkpoint blockade molecule involved in negative regulation of the immune response. It was reported that exosomes could transfer functional PD-L1 locally and distantly to suppress the antitumor immune response. However, whether 5-FU alters the expression of exosomal PD-L1 and induces immunosuppression in gastric cancer remains unclear. Herein, we found that 5-FU increased gastric cancer-derived exosomal PD-L1. Importantly, compared with baseline levels, circulating exosomal PD-L1 was significantly upregulated in 21 stage III–IV gastric cancer patients after two, four, and six repeated cycles of fluoropyrimidine treatment (P = 0.009, P = 0.047, and P = 0.023, respectively), accompanied by decreased amounts of IFN-γ, TNF-α, IL-2, IL-6, and GM-CSF (P = 0.014, P = 0.004, P = 0.009, P = 0.031, and P = 0.014, respectively). Additionally, circulating exosomal PD-L1 was increased more significantly in clinical non-responders compared with responders (P = 0.018). Furthermore, exosomal PD-L1 induced apoptosis in Jurkat T cells and inhibited T cell activation in PBMCs, which could be partly reversed by nivolumab. These results suggested that 5-FU-induced upregulation of exosomal PD-L1 causes systemic immunosuppression in advanced gastric cancer following multiple cycles of chemotherapy, especially after two cycles.</p
Table_1_5-FU-Induced Upregulation of Exosomal PD-L1 Causes Immunosuppression in Advanced Gastric Cancer Patients.DOCX
No full textAlthough the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU) is generally considered to directly kill cancer cells and exert immunostimulatory effects in advanced gastric cancer, accumulating evidence indicates that it upregulates the expression of PD-L1, a representative immune checkpoint blockade molecule involved in negative regulation of the immune response. It was reported that exosomes could transfer functional PD-L1 locally and distantly to suppress the antitumor immune response. However, whether 5-FU alters the expression of exosomal PD-L1 and induces immunosuppression in gastric cancer remains unclear. Herein, we found that 5-FU increased gastric cancer-derived exosomal PD-L1. Importantly, compared with baseline levels, circulating exosomal PD-L1 was significantly upregulated in 21 stage III–IV gastric cancer patients after two, four, and six repeated cycles of fluoropyrimidine treatment (P = 0.009, P = 0.047, and P = 0.023, respectively), accompanied by decreased amounts of IFN-γ, TNF-α, IL-2, IL-6, and GM-CSF (P = 0.014, P = 0.004, P = 0.009, P = 0.031, and P = 0.014, respectively). Additionally, circulating exosomal PD-L1 was increased more significantly in clinical non-responders compared with responders (P = 0.018). Furthermore, exosomal PD-L1 induced apoptosis in Jurkat T cells and inhibited T cell activation in PBMCs, which could be partly reversed by nivolumab. These results suggested that 5-FU-induced upregulation of exosomal PD-L1 causes systemic immunosuppression in advanced gastric cancer following multiple cycles of chemotherapy, especially after two cycles.</p
Fault location in a marine low speed two stroke diesel engine using the characteristic curves method
No full textWhen a malfunction occurs in a marine main engine system, the impact of the anomaly will
propagate through the system, affecting the performance of all relevant components in the system. The
phenomenon of fault propagation in the system caused by induced factors can interfere with fault
localization, making the latter a difficult task to solve. This paper aims at showing how the
“characteristic curves method” is able to properly locate malfunctions also when more malfunctions
appear simultaneously. To this end, starting from the working principle of each component of a real
marine diesel engine system, comprehensive and reasonable thermal performance parameters are
chosen to describe their characteristic curves and include them in a one-dimensional thermodynamic
model. In particular, the model of a low-speed two stroke MAN 6S50 MC-C8.1 diesel engine is built
using the AVL Boost software and obtaining errors lower than 5% between simulated values and test
bench data. The behavior of the engine is simulated considering eight multi-fault concomitant
phenomena. On this basis, the fault diagnosis method proposed in this paper is verified. The results
show that this diagnosis method can effectively isolate the fault propagation phenomenon in the system
and quantify the additional irreversibility caused by the Induced factors. The fault diagnosis index
proposed in this paper can quickly locate the abnormal components
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