65 research outputs found
An Exploration of Transformer and Convolution Layers in Medical Image Segmentation
No full textDeep convolutional neural networks (DCNNs) are a popular deep learning technique that has been widely used in segmentation tasks and has received positive feedback. However, DCNN-based frameworks are known to be inadequate in dealing with global relations within imaging features when it comes to segmentation tasks. While several techniques have been proposed to enhance the global reasoning of DCNN, these models are either unable to achieve satisfactory performance compared to traditional fully-convolutional structures or unable to utilize the fundamental advantages of CNN-based networks, namely the ability of local reasoning. In this study, we designed a novel attention mechanism for 3D computation and used it to fully extract the self-attention ability. We proposed a new segmentation framework (called 3DTU) for three-dimensional medical image segmentation tasks, which processes images in an end-to-end manner and performs 3D computation on both the encoder side (with a 3D transformer) and the decoder side (based on a 3D DCNN). In comparison to existing attempts to combine FCNs and global reasoning methods, our framework outperforms several state-of-the-art segmentation methods on two independent datasets consisting of 3D MRI and CT images, as evidenced by experimental results
Practicing Strategy and Performance Preparation of György Ligeti’s \u3ci\u3eMusica Ricercata\u3c/i\u3e.
No full textABSTRACT Hungarian composer György Ligeti (1923–2006) is renowned as one of the most significant composers of the twentieth century. Musicians around the world have admired his innovative musical language. “Through the 1950s and 1960s, he went from composing in the style of his countryman Béla Bartók to working at the cutting edge of the Western European avant-garde.” His folk elements and avant-garde compositional techniques expanded through various genres, including orchestral, chamber, and keyboard compositions. This study\u27s primary purpose is to explore Ligeti\u27s piano work Musica Ricercata and ultimately provide a resource to other musicians that will assist in preparing and performing this work. This study provides a chronological history of Musica Ricercata, including its inspiration and influences. It explores Ligeti’s biography during the 1950s–1960s with background information about the political situation. The study then focuses on how Béla Bartók influenced Ligeti’s compositional journey and how Musica Ricercata influenced Ligeti’s later works. The research also focuses more specifically on the inspirations of each movement while examining its compositional traits. Following this, the study will provide detailed explorations of the major technical challenges presented in the work and provide ways to solve these challenges. It is the hope of the author that this study will enable players to learn the music efficiently and provide thoughtful advice to guide them from the initial learning process to the final performance. The study is divided into seven chapters. Chapter 1 covers the introduction, purpose, need, and limitations of the study. Chapter 2 focuses on Ligeti\u27s biography and the compositional background of Musica Ricercata. Chapter 3 explores the influence of Bartok’s compositional style on Ligeti. Chapter 4 provides an analysis of Musica Ricercata with regard to technical difficulties as well as practice advice for each movement. Chapter 5 explores the influence of Ligeti’s Musica Ricercata on his later works in similar compositional style. Chapter 6 explains psychological preparation and strategy before performance. Chapter 7 serves as the conclusion of the entire study
An Improved Fingerprint Algorithm of 3D-DCT for Video Fingerprinting
No full textIn this paper, a new learned basis set algorithm (3D-LBT) based on 3D-DCT (Discrete Cosine Transform) is proposed for video fingerprinting and matching, in which for different video categories an Adaboost-based machine learning method is applied to each category of videos for selecting suitable sets of 3D-DCT coefficients to generate fingerprints, and a weighted distance of fingerprints is also defined for fingerprint matching. Our experimental results have illustrated that the proposed algorithm outperforms the conventional 3D-DCT algorithm and the 3D-RBT (Randomized Basis seT) algorithm in terms of robustness and uniqueness. Moreover, the proposed algorithm has better security performance for copyright applications.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000349789200052&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Engineering, Electrical & ElectronicImaging Science & Photographic TechnologyEICPCI-S(ISTP)
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux
No full textThe metabolism and apoptosis of tumor cells are important factors that increase their sensitivity to chemotherapeutic drugs. p53 and cisplatin not only induce tumor cell apoptosis, but also regulate the tumor cell metabolism. The TP53-induced glycolysis and apoptosis regulator (TIGAR) can inhibit glycolysis and promote more glucose metabolism in the pentose phosphate pathway. We speculate that the regulation of the TIGAR by the combination therapy of p53 and cisplatin plays an important role in increasing the sensitivity of tumor cells to cisplatin. In this study, we found that the combined treatment of p53 and cisplatin was able to inhibit the mitochondrial function, promote mitochondrial pathway-induced apoptosis, and increase the sensitivity. Furthermore, the expression of the TIGAR was inhibited after a combined p53 and cisplatin treatment, the features of the TIGAR that regulate the pentose phosphate pathway were inhibited, the glucose flux shifted towards glycolysis, and the localization of the complex of the TIGAR and Hexokinase 2 (HK2) on the mitochondria was also reduced. Therefore, the combined treatment of p53 and cisplatin may modulate a glycolytic flux through the TIGAR, altering the cellular metabolic patterns while increasing apoptosis. Taken together, our findings reveal that the TIGAR may serve as a potential therapeutic target to increase the sensitivity of lung cancer A549 cells to cisplatin
DataSheet1_Fast degradation of carbamazepine in water by electric discharge plasma.docx
No full textThe proliferation of pharmaceuticals in the aqueous environment has adversely impact on human health and ecosystem balance. Pharmaceutical contaminations are difficult to remove effectively by conventional treatment technologies. In order to degrade carbamazepine (CBZ) efficiently, a common antiepileptic drug, three plasma discharge modes were studied, including liquid-phase discharge, air gas-liquid jet and dielectric barrier discharge. It is noteworthy that the degradation efficiency and energy yield reached to highest levels (0.11 g/kWh) when operating at 225 W input power under liquid phase discharge, compared with the other discharge modes. The parameters of concentration, electrode distance, volume, input power and frequency of the discharge were also evaluated and optimized. Plasma emission spectroscopy revealed the degradation process is mainly attributed to reactive oxygen species (ROS), while the role of reactive nitrogen species was not significant. The contributions of diverse ROS were assessed by radical quenching experiments, including p-benzoquinone, p-phthalic acid and tert-butanol. The possible degradation intermediates and pathways of CBZ were tested and analyzed by liquid chromatography-mass spectrometry (LC-MS). Comprehensively consideration of cleanliness, degradation efficiency and application difficulty, liquid-phase discharge treatment is a promising technology for water treatment.</p
How Fear of External Threats Plays Roles: An Examination of Supervisors’ Trait Anger, Abusive Supervision, Subordinate Burnout and CCB
No full textIn times of uncertainty, such as during COVID-19, many organizations experience profit decline, and employees develop a fear of external threats, such as organizational layoffs. However, most of the literature focuses on how people’s fear influences their well-being. Less is known about how employees’ fear of external threats influences their workplace behaviors. The current study proposes that supervisors’ fear of external threats stimulates those who are high in trait anger to behave in a more abusive way. Simultaneously, subordinates’ fear of external threats would strengthen the positive relationship between abusive supervision and their burnout and compulsory citizenship behaviors (CCB), as fear of external threats constrains their response options to abusive supervision. We tested the hypotheses with a multiwave and multisource survey study (N = 322 dyads) in China, and the results showed that supervisors’ fear of external threats strengthened the positive effect of trait anger on abusive supervision. Subordinates’ fear of external threats strengthens the positive relationships of abusive supervision with CCB and the mediating effect of abusive supervision in the relationship of supervisors’ trait anger with subordinates’ CCB. Our study enriches people’s understanding of how supervisors’ and subordinates’ fear of external threats may play roles in workplace behaviors
Morphological and Physiological Changes in Sedum spectabile during Flower Formation Induced by Photoperiod
No full textSedum spectabile is an ornamental herbaceous perennial considered as a long-day plant. Varying levels of hormones and sugars possibly affect flower bud formation. This study aimed to determine the changes in endogenous hormones, sugars, and respiration levels in leaves and in apical buds. In addition, the current research was also conducted to observe the morphological changes during the induction, initiation and development of flower buds. Results showed that the periods of floral induction, initiation and development of S. spectabile were the period from 0 d to 1 d, 2 d to 10 d and after 11 d respectively under long day of 20 hours. High zeatin level in apical buds was conducive to floral induction; the increasing levels of gibberrelin and indole acetic acid favor floral initiation; floral development was regulated by mutually synergistic and antagonistic relationships of hormones. The total starch content in leaves remarkably decreased during floral induction. Moreover, soluble sugar content increased and reached the maximum level at 20 d of the treatment period. Afterward, soluble sugar content declined rapidly and was probably transported to the apical buds for rapid floral development. Furthermore, the total respiration of leaves maintained an upward trend; the cytochrome pathway also maintained an increasing trend after the plants were treated for 20 d. Such changes may favour the morphological differentiation of apical buds in floral development
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