3,457 research outputs found
Efficacy of IRI/5-FU and IrC™/5-FU treatment in the HT-29 s.c. model of CRC.
No full text<p>Mice bearing s.c. HT-29 tumors were treated with saline+D5W (grey solid square), 5-FU (16 mg/kg; black solid upright triangle), IRI (60 mg/kg; grey solid diamond), IrC™ (40 or 60 mg IRI/kg; black solid inverted triangle or black solid circle, respectively), IRI +5-FU (60 mg/kg +16 mg/kg; black open circle), or IrC™ +5-FU (40 mg IRI/kg +16 mg/kg; grey solid star). Beginning on day 14, D5W and 5-FU were administered QD×5 (x 3 weeks) via i.p. injection (arrowheads); all other treatments were administered Q7D×3 via i.v. injection (full arrows). Data are presented as mean fold tumor volume increase +/− standard error of the mean (n = 6).</p
Attitudes of Three Fu on “Yushan” towards the Garden and Its Owner
No full text晚明時期，祁彪佳在山陰城外闢建寓山園林，當時文人以各種文體進行題詠、唱和，共同參與寓山的詮釋活動。除大量詩歌、園記之外，今日仍存見三篇賦作，作者分別為陳遯、陳函煇、陳子龍。本文以三人之〈寓山賦〉為觀察核心，嘗試呈現晚明文人園林賦曾有的試驗與努力。主要討論視點有三：一為書寫者與園林主人的交遊關係，如何影響賦篇書寫角度的擬立？二為園林賦如何詮釋主人賦予空間的意義，尤其回應著晚明時局，主人出處之際的選擇如何影響空間意義中心的認取？三為賦體作為晚明園林書寫的文類之一，如何繼承「鋪采摛文，體物寫志」的傳統特質，以與園林主題相結合？在他們的討論中，園林與主人密切結合的性質，彰顯了寓山與自然山林的差異；而書寫者與主人的交遊與瞭解，影響著對園林的觀看角度與詮說，三陳〈寓山賦〉的差異，也正反映出他們撰作之際，與祁彪佳相互交會的光亮所能照見的能見度。During the end of the Ming dynasty, Qi Biaojia (祁彪佳) built his “Yushan” (寓山) garden in the outskirts of the city of Shanyin (山陰). Literati of the time participated in the interpretation of this garden with odes and reply-response pieces in a number of different styles. In addition to the large number of poem, and prose pieces, three works in the fu (賦) style written by Chen Dun (陳遯, date of birth and death unknown), Chen Hanhui (陳函輝, 1590-1646), and Chen Zilong (陳子龍, 1608-1647) have survived. This paper uses these three works in an effort to show the experimentation with and efforts put into writing fu on the subject of gardens by the literati of the late Ming. Three main questions are discussed. First, how did the relation between writer and owner affect the writing angle of three fu ? Second, how did fu written about gardens interpret the meaning invested in the space by the owner, and, particularly in light of the political situation of the time, how did the owner’s choice to either take office or stay out of public life affect the meanings imparted in the garden space? Third, given that literati during the late Ming did in fact use the fu style to write about gardens, how did they go about utilizing the characteristic of the fu as “stacking colors and layering shades, shaping objects and expressing thoughts (鋪采摛文，體物寫志)? In these works, the close connection of the garden with their owner brings to light the difference between this garden and the natural mountain terrain, while at the same time the writer’s relation to and understanding of the owner will also affect the perspective with which they look at the garden and their interpretation of it
Clinical and biochemical risk factors for first and recurrent episodes of venous thrombosis
Full text linkThe objectives of this thesis were to study the magnitude of the risk of venous thrombosis (VT) in the general population, and to determine clinical and biochemical factors that influence this risk. We examined this separately for first and for recurrent thrombotic events: TROL, a Norwegian prospective follow-up study in the population, in which we counted patients with a 1st event of VT and LETS, a follow-up of a Dutch cohort of 474 consecutive patients with a 1st objectively confirmed VT. The incidence rates for all first VT events was 1.43 per 1000 person-years and increased exponentially with age, and were slightly higher in women than in men. Patients with pre-existing inflammation or anticardiolipin antibodies did not have any increased risk for subsequent VT disease. We found that high levels of homocysteine are at most a weak risk factor for subsequent VT. In the LETS-study, the rate of VT recurrence was 25.9 per 1000 patient-years. The risk of recurrence was 2.7 times higher in men than in women. Recurrence risk was increased if the initial VT was unprovoked or if women used oral contraceptives during follow-up. Surprisingly, there was no clear relation between recurrence risk and the presence of thrombophiliaThe studies were financial supported by grants from the Prevention Fund/ZonMW (grant no.2827170), the Netherlands Heart Foundation (grants no. 2000B185, 89.063), the Research Council of Norway (grant no. 148037) and the research council of Helse Sunnmøre (grants no. 56-FU-69-05, 56-FU-52-07, 56-FU-20-08, 56-FU-07-09)UBL - phd migration 201
Natural Variation of the Circadian Clock in Neurospora
No full textMost living organisms on earth experience daily and expected changes from the rotation of the earth. For an organism, the ability to predict and prepare for incoming stresses or resources is a very important skill for survival. This cellular process of measuring daily time of the day is collectively called the circadian clock. Because of its fundamental role in survival in nature, there is a great interest in studying the natural variation of the circadian clock. However, characterizing the genetic and molecular mechanisms underlying natural variation of circadian clocks remains a challenging task. In this chapter, we will summarize the progress in studying natural variation of the circadian clock in the successful eukaryotic model Neurospora, which led to discovering many design principles of the molecular mechanisms of the eukaryotic circadian clock. Despite the success of the system in revealing the molecular mechanisms of the circadian clock, Neurospora has not been utilized to extensively study natural variation. We will review the challenges that hindered the natural variation studies in Neurospora, and how they were overcome. We will also review the advantages of Neurospora for natural variation studies. Since Neurospora is the model fungal species for circadian study, it represents over 5 million species of fungi on earth. These fungi play important roles in ecosystems on earth, and as such Neurospora could serve as an important model for understanding the ecological role of natural variation in fungal circadian clocks.Advances in Genetics, Vol. 99
A thermal emitter with selective wavelength: Based on the coupling between photonic crystals and surface plasmon polaritons
No full textCorrigendum to “A generic multi-level framework for microscopic traffic simulation with automated vehicles in mixed traffic” [Transport. Res. Part C: Emerg. Technol. 110 (2020) 291–311] (Transportation Research Part C (2020) 110 (291–311), (S0968090X19304322), (10.1016/j.trc.2019.11.019))
No full textThe authors regret that a contributing author was missing from the list of authors. The complete list of authors should be: “S.C. Calvert, B. van Arem, & J. W. C. van Lint”. All are with Delft University of Technology, Department of Transport & Planning, The Netherlands updated as above. The authors would like to apologise for any inconvenience caused.Transport and Plannin
Hybrid simulation for health and social care: the way forward, or more trouble than it’s worth?
No full textTowards the Holy Grail: combining system dynamics and discrete-event simulation in healthcare
No full textThe idea of combining discrete-event simulation and system dynamics has been a topic of debate in theoperations research community for over a decade. Many authors have considered the potential benefits ofsuch an approach from a methodological or practical standpoint. However, despite numerous examples ofmodels with both discrete and continuous parameters in the computer science and engineering literature,nobody in the OR field has yet succeeded in developing a genuinely hybrid approach which truly integratesthe philosophical approach and technical merits of both DES and SD in a single model. In this paperwe consider some of the reasons for this and describe two practical healthcare examples of combinedDES/SD models, which nevertheless fall short of the “holy grail” which has been so widely discussed inthe literature over the past decade
A Study of Li Yide’s Annotated Compilation of the Zuozhuan Commentaries by Jia Kui and Fu Qian
No full text清代「漢學」的主流趨勢下，學者依漢儒古義以解經，並相對於十三經注疏另撰新疏。李貽德在此學風影響之下，企慕孫星衍與洪亮吉等乾嘉諸儒之學，汲取既有之成果，輯存賈逵、服虔之《左傳》舊注，依以申述，向新疏之撰成再邁前一步。清儒群經新疏薈萃一代經學的主要成果，而在清代《左傳》學從古義到新疏的發展脈絡中，李氏的著作無疑佔有重要地位。 During the Qinb dynasty, Confucian scholars who came under the influ-ence of the mainstream "Han Learning" often relied heavily on the Han Confucian guyi (古義) to interpret the Classics. They even went so far as to propose new commentaries vis-?-vis the long-standing Shisanjing Zhushu (十三經注疏). Given the influence of this scholarly direction, Li Yide (李貽德) had great respect for the scholarship of Qian-Jia scholars such as Sun Xingyen (孫星衍) and Hong Liangji (洪亮吉). Drawing substantially on the results of their works, Li compiled the Zouzhuan (左傳) commentaries by Jia Kui (賈逵) and Fu Qian (服虔), and thereby made significant advancements towards the completion of new subcommentaries. These new commentaries and subcommentaries constituted the major accomplishments of the Qing studies of Confucian Classics. Within the Zouzhuan studies, in particular, Li Deyi's work undoubtedly occupied a vital position in the development from guyi to new subcommentaries
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