584 research outputs found
Bioinformatics for genetical genomics : novel experimental design and algorithms
No full textJingyuan Fu promoveert op een onderzoek naar genetische analyses. Onder andere werkte ze aan een nieuw softwarepakket MetaNetwork, dat hulp biedt bij het zoeken naar een optimaal ontwerp van experimenten op het gebied van genetical genomics.
Bioinformatics for genetical genomics:novel experimental design and algorithms
No full textJingyuan Fu promoveert op een onderzoek naar genetische analyses. Onder andere werkte ze aan een nieuw softwarepakket MetaNetwork, dat hulp biedt bij het zoeken naar een optimaal ontwerp van experimenten op het gebied van genetical genomics
Bioinformatics for genetical genomics:novel experimental design and algorithms
No full textJingyuan Fu promoveert op een onderzoek naar genetische analyses. Onder andere werkte ze aan een nieuw softwarepakket MetaNetwork, dat hulp biedt bij het zoeken naar een optimaal ontwerp van experimenten op het gebied van genetical genomics
Publisher Correction:Age-dependent sex differences in cardiometabolic risk factors
Full text linkCorrection to: Nature Cardiovascular Research, published online 12 September 2022. In the version of this article initially published, Lude Franke, Jan A. Kuivenhoven, Alexandra Zhernakova and Jingyuan Fu were listed in the Lifelines Cohort Study group but were omitted from the main author list, while Jan A. Kuivenhoven was mistakenly included in the study group. The errors have been corrected in the HTML and PDF versions of the article.</p
Identification of key differentially methylated genes regulating muscle development in chickens: insights from Jingyuan breed
No full textABSTRACT: Skeletal muscle development is a complex, regulated physiological process that involves myoblast proliferation and differentiation and the fusion of myotubes. In this study, phenotypic differences in the breast and leg muscles of 180-day-old Jingyuan chickens were investigated. Differentially methylated genes (DMG) that regulate muscle development were identified through differential expression analysis and weighted gene co-expression network analysis. Moreover, myoblasts were used as test material and treated with cycloleucine to investigate the effect of N6-methyladenosine (m6A) modification on their proliferation and differentiation. The results revealed that the myofiber diameter and cross-sectional area in the breast muscle of Jingyuan chickens were significantly smaller than those in the leg muscle, while myofiber density in the breast muscle was significantly higher. A total of 484 DMG were identified in both muscle types. Module gene association analysis with DMGs revealed multiple DMG associated with muscle development. In vitro cell model analysis revealed that cycloleucine treatment significantly downregulated the m6A modification level of myoblasts and inhibited their proliferation and differentiation. Additionally, stage-specific differences in LDHA, LDHB, and GAPDH expressions were observed during myoblast differentiation. Cycloleucine treatment significantly inhibited LDHA, LDHB, and GAPDH expression. These findings indicate that m6A methylation modifications play significant regulatory roles in muscle development, with LDHA, LDHB, and GAPDH being potential candidate genes for regulating muscle development. This study provides an essential theoretical basis for further study on the functional mechanisms of m6A modifications involved in muscle development
sj-xlsx-2-try-10.1177_11786469221126888 – Supplemental material for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV
No full textSupplemental material, sj-xlsx-2-try-10.1177_11786469221126888 for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV by Nadira Vadaq, Yue Zhang, Elise Meeder, Lisa Van de Wijer, Muhammad Hussein Gasem, Leo AB Joosten, Mihai G Netea, Quirijn de Mast, Vasiliki Matzaraki, Arnt Schellekens, Jingyuan Fu and André JAM van der Ven in International Journal of Tryptophan Researc
sj-xlsx-2-try-10.1177_11786469221126888 – Supplemental material for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV
No full textSupplemental material, sj-xlsx-2-try-10.1177_11786469221126888 for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV by Nadira Vadaq, Yue Zhang, Elise Meeder, Lisa Van de Wijer, Muhammad Hussein Gasem, Leo AB Joosten, Mihai G Netea, Quirijn de Mast, Vasiliki Matzaraki, Arnt Schellekens, Jingyuan Fu and André JAM van der Ven in International Journal of Tryptophan Research</p
sj-docx-1-try-10.1177_11786469221126888 – Supplemental material for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV
No full textSupplemental material, sj-docx-1-try-10.1177_11786469221126888 for Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV by Nadira Vadaq, Yue Zhang, Elise Meeder, Lisa Van de Wijer, Muhammad Hussein Gasem, Leo AB Joosten, Mihai G Netea, Quirijn de Mast, Vasiliki Matzaraki, Arnt Schellekens, Jingyuan Fu and André JAM van der Ven in International Journal of Tryptophan Research</p
Decoding non-coding RNAs in fatty liver disease
Full text linkNon-alcoholic fatty liver disease (NAFLD) encompasses a range of liver disorders, from simple deposition of fat in the liver (hepatic steatosis) to more severe phenotypes characterized by the presence of inflammation, ballooning and fibrosis (non-alcoholic steatohepatitis or NASH). Obesity is the major risk factor for NAFLD and, driven by the global obesity epidemic, NAFLD has become the leading cause of chronic liver disease worldwide. 10-20% of NASH patients will progress further towards cirrhosis and hepatocellular carcinoma (HCC) which, in view of their increasing prevalence, will become frequent indications for liver transplantation. It is therefore important to understand the mechanisms involved in NAFLD etiology, in order to prevent its development as well as its progression towards more severe conditions. It has been estimated that more than 98% of human genome is now considered as the non-coding genome. Interestingly, a large part of non-coding genome is found to be transcribed into non-coding RNAs (ncRNAs) that can participate in a number of critical biological processes, such as chromatin remodeling, gene transcription and protein transport and trafficking, thus implicating ncRNAs in a wide range of complex human diseases. However, the involvement of ncRNAs in the liver and in NAFLD development and progression is not well understood. In this thesis we aim to understand the role of ncRNAs in NAFLD by combining transcriptome profiling in a patient cohort, functional genomics in in vitro models to mimic disease progression, and follow-up functional studies using various molecular techniques. This research highlights the importance of ncRNAs in NASH
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