65 research outputs found
Infestation of Platypodine Beetles (Coleoptera: Curculionidae) on Rubber Trees in China
No full textLai, Shengchang, Wang, Jianguo, Fu, Yueguan, Duan, Bo, Hongchang, A, Zhang, Ling, Tarno, Hagus (2020): Infestation of Platypodine Beetles (Coleoptera: Curculionidae) on Rubber Trees in China. The Coleopterists Bulletin 74 (3): 626-631, DOI: 10.1649/0010-065X-74.3.626, URL: http://dx.doi.org/10.1649/0010-065x-74.3.62
Next generation ex vivo patient-derived tumour explant model for immunotherapy
No full textOver the past decade, immunotherapy has become a new pillar of cancer treatment. Despite the success of some therapeutic agents, most patients do not benefit. This can be attributed to several factors. Clinically, there is a lack of effective therapeutic targets. Pre-clinically, there is a lack of models that accurately recapitulate the patient tumour microenvironment (TME). This discrepancy highlights the urgent need for models that can close this gap. The patient-derived tumour explant model (PDE) offers a preclinical model that mimics the patient tumour microenvironment.
Studies have used this model to predict the clinical response to standard-of-care immunotherapies. However, as it preserves an intact patient TME, its use for dissecting the immune- and tumour intrinsic mechanisms remains largely underexplored. In this thesis, I investigated the potential of PDE for the pharmacological modulation of tumour cell-intrinsic pathways, the nonsense-mediated decay pathway with SMG1 inhibitors, leading to anti-tumour immunogenicity, where such an elevated response is tumour-specific and not in normal-adjacent tissue. Furthermore, the PDE model was further explored to modulate immune-cell-intrinsic mechanisms. Three biological pathways were targeted with novel therapeutic agents, focusing on T cells, macrophages, and dysfunctional dendritic cells, respectively. Among these targets, the anti-OSM antibody was successfully proven to reduce the percentage of dysfunctional CD8+ T cells, paving the way for preclinical possibilities in combination therapies alongside standard-of-care immunotherapies.
Meanwhile, technical innovations were developed to tackle some of the challenges in the PDE field. These efforts aimed to enhance viability and support the perfusion of external cells by vascularising PDEs with genetically engineered HUVECs and microfluidics. In summary, this thesis provides a comprehensive overview of the field. These findings and innovations highlight PDE as a promising next-generation preclinical model for cancer immunotherapy
Long-term deterioration of lubricant-infused nanoporous anodic aluminium oxide surface immersed in NaCl solution
No full textThis study investigated the deterioration of a lubricant-infused anodic aluminium oxide surface in a 1 M NaCl solution for ∼200 days. Direct observation by cryo-SEM and quantitative analyses by UV spectroscopy and EIS revealed that the long-term deterioration of the lubricant-infused surface was divided into two stages: the surface-adhered lubricant layer gradually dissolved at a constant rate until the substrate was exposed; afterwards the lubricant infused in the nanochannels began to diffuse and was depleted after ∼200 days. The EIS results also revealed that the defects reduced the corrosion resistance of the lubricant-infused surface considerably.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
The effect of riboflavin on the microbiologically influenced corrosion of pure iron by Shewanella oneidensis MR-1
No full textThe microbiologically influenced corrosion of pure iron was investigated in the presence of Shewanella oneidensis MR-1 with various levels of exogenous riboflavin (RF) serving as electron shuttles for extracellular electron transfer (EET). With more RF available, a larger and denser phosphate layer was formed on the surface of pure iron by the bacteria. The results of electrochemical impedance spectroscopy, linear polarization resistance and potentiodynamic polarization tests showed that the product layer provided good corrosion protection to the pure iron. Using electrochemical noise, we observed that the addition of RF accelerated the corrosion at the initial stage of immersion, thereby accelerating the deposition of products to form a protective layer subsequently.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Arjan Mo
Algorithm research for user trajectory matching across social media networks based on paragraph2vec
No full textData_Sheet_2_Association between appendicular lean mass and chronic obstructive pulmonary disease: epidemiological cross-sectional study and bidirectional Mendelian randomization analysis.ZIP
No full textBackgroundThe association of BMI with COPD, and sarcopenia in COPD have been both confirmed by several studies, but research on the relationship and causality of body lean mass and the risk of chronic obstructive pulmonary disease (COPD) remains to be discovered. The purpose of this study was to explore the association between lean mass and COPD risk as well as to further examine the causal relationship in the findings.MethodsThree thousand four hundred fifty-nine participants from NHANES 2013–2018 were included in the epidemiological cross-sectional study to assess the association between relative lean mass and COPD by restricted spline analysis (RCS) and weighted multiple logistic regression. Furthermore, to verify the causality between lean mass and COPD, a two-sample Mendelian randomization (MR) with inverse variance weighting (IVW) method was used to analyze GWAS data from European ancestry. Genetic data from the United Kindom Biobank for appendicular lean mass (450,243 cases) and lung function (FEV1/FVC) (400,102 cases) together with the FinnGen platform for COPD (6,915 cases and 186,723 controls) were used for MR.ResultsWeighted multiple logistic regression showed a significant correlation between relative appendicular lean mass and COPD after adjusting for confounders (OR = 0.985, 95% CI: 0.975–0.995). Compared to the lower mass (155.3–254.7) g/kg, the high mass (317.0–408.5) g/kg of appendicular lean apparently decreases the risk of COPD (OR = 0.214, 95% CI: 0.060–0.767). Besides, in the analysis of MR, there was a forward causality between appendicular lean mass and COPD (IVW: OR = 0.803; 95%CI: 0.680–0.949; p = 0.01), with a weak trend of causality to lung function.ConclusionOur study not only found an inverse association between appendicular lean mass and COPD but also supported a unidirectional causality. This provided possible evidence for further identification of people at risk for COPD and prevention of COPD based on limb muscle exercise and nutritional supplementation to maintain skeletal muscle mass.</p
Data_Sheet_1_Association between appendicular lean mass and chronic obstructive pulmonary disease: epidemiological cross-sectional study and bidirectional Mendelian randomization analysis.PDF
No full textBackgroundThe association of BMI with COPD, and sarcopenia in COPD have been both confirmed by several studies, but research on the relationship and causality of body lean mass and the risk of chronic obstructive pulmonary disease (COPD) remains to be discovered. The purpose of this study was to explore the association between lean mass and COPD risk as well as to further examine the causal relationship in the findings.MethodsThree thousand four hundred fifty-nine participants from NHANES 2013–2018 were included in the epidemiological cross-sectional study to assess the association between relative lean mass and COPD by restricted spline analysis (RCS) and weighted multiple logistic regression. Furthermore, to verify the causality between lean mass and COPD, a two-sample Mendelian randomization (MR) with inverse variance weighting (IVW) method was used to analyze GWAS data from European ancestry. Genetic data from the United Kindom Biobank for appendicular lean mass (450,243 cases) and lung function (FEV1/FVC) (400,102 cases) together with the FinnGen platform for COPD (6,915 cases and 186,723 controls) were used for MR.ResultsWeighted multiple logistic regression showed a significant correlation between relative appendicular lean mass and COPD after adjusting for confounders (OR = 0.985, 95% CI: 0.975–0.995). Compared to the lower mass (155.3–254.7) g/kg, the high mass (317.0–408.5) g/kg of appendicular lean apparently decreases the risk of COPD (OR = 0.214, 95% CI: 0.060–0.767). Besides, in the analysis of MR, there was a forward causality between appendicular lean mass and COPD (IVW: OR = 0.803; 95%CI: 0.680–0.949; p = 0.01), with a weak trend of causality to lung function.ConclusionOur study not only found an inverse association between appendicular lean mass and COPD but also supported a unidirectional causality. This provided possible evidence for further identification of people at risk for COPD and prevention of COPD based on limb muscle exercise and nutritional supplementation to maintain skeletal muscle mass.</p
Robust Control under Uncertainty for Seaport Handling Equipments
No full textAbstractUncertainty in transport includes mainly unavailability of transportation resource, durations of maintenance activities and the infrastructure constraints. The uncertainty influences the transportation resource availability, and consequently the planned transport schedule. Developments presented in this paper are devoted to the robustness control of transportation system. A robust control strategy towards uncertainty is presented. The presented control strategy tries to reduce unavailability of machines in transportation system and to minimize the total transfer time. To illustrate the effectiveness and accuracy of proposed robustness approach, an application to a seaport handling equipments is outlined
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