2,493 research outputs found
Forest plot of the primary efficacy outcome of 2G-CB for PerAF at the one-year FU.
No full textForest plot of the primary efficacy outcome of 2G-CB for PerAF at the one-year FU.</p
Forest plot of the primary efficacy outcome of 2G-CB for PerAF at a mid-term FU.
No full textForest plot of the primary efficacy outcome of 2G-CB for PerAF at a mid-term FU.</p
A historical comment about the GVT in short interval
No full textIn this article, the author introduces the history, progress and method in the Goldbach-Vinogradov Theorem in short interval by which every sufficiently large odd integer could be expressed as the sum of three almost equal prime numbers.http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000183488400018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701MathematicsCPCI-S(ISTP)
Investigation on the DC CB Performance during a Current Interruption Failure at First Current Zero
No full textThe vacuum interrupter is used as the key component of an active DCCB due to its excellent interruption and dielectric recovery characteristics after current zero. The vacuum interrupter can only interrupt the fault currents below the limitation of a critical di/dt and TIV, otherwise it causes a reignition and the interruption failure. In this paper, a detailed active injection DC CB model is developed, considering operation delay of switches, parasitic parameters of switches and thorough control logic. The limitation dielectric strength between the vacuum gap is defined by the cold break down voltage. Based on the numerical modelling, investigation will be performed to see the performance of DC CB with a failure interruption on the first current zero. The simulation results can help to optimize the injection circuit parameters when DC CB has a failure on the first current zero and has to interrupt in the next current zeros. This algorithm will consider predefined threshold of di/dt, chopping current and variable operation time in different scenarios.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Intelligent Electrical Power Grid
Segreti e virtù dello scorpione nelle carte Estensi
No full textUn'opera manoscritta di dedica a Ercole I d'Este di Massa Baptista de Argenta (Ms. XV sec.) rivela nelle ultime carte bianche una ricetta, l'olio di scorpioni nella formula più semplice, conosciuta con il nome di San Bernardino: Scorpioni ben aizzati, Olio antico El quale olio vale contra peste contra veneno contra morsus vipis.
Il composito - che fu nel Cinquecento la fortuna dei Castagno medici spagnoli alla Corte Estense - over'oglio contra peste, & veleni, che si fa ogn'anno per l'illustrissima comunità di Ferrara è a formula segreta. Non viene rivelata, se non nell'uso, in nessuna delle edizioni - dalla prima manoscritta all'ultima delle numerose a stampa - del Reggimento contra peste.
Nel Ricettario medico-cosmetico (Ms. XVI sec) denominato Pseudo-Savonarola viene ripreso il Modo d'usar l'olio de m. Tomaso da Lucca contro la peste [...] si unge il cuore e tutti li polsi e se ne beve due gocce una sola volta con un poco di vino bianco.
Il recupero negli Archivi di note di spesa (1568 e 1591) delle robe comprate in Venetia per fare il composito [...] in la spiciaria dell'Ospitale della beata S. Anna, per Zan Paulo Castagno indicherebbe un'alta corrispondenza con la ricetta nota del Mattioli. Il Nigrisoli (Farmacopea ferrarese, 1723) conferma questa ipotesi: gli oli, indicando per primo l'olio del Mattioli, non multum distant à compositione dell'olio ferrarese, che risulta comunque il più valente.
Il veleno dello scorpione studiatissimo oggi rivela, tra le molte, attività antimicrobica, immunizzante, antitumorale, antidolorifica, afrodisiaca
Technical performance of different DC CB technologies for future HVDC Grids
No full textMultiterminal dc (MTDC) network is preferred due to its reliability, security of supply and flexibility. However, MTDC network also comes with the protection challenges resulting from dc faults. Hence, the dc circuit breaker (DC CB) is imperative in such a network. In these recent years, several DC CB technologies have been proposed and demonstrated by different manufacturers. Besides, these DC CB technologies differ from each other in terms of the speed of operation, interruption capability and costs. Hence, for the optimal performance of the MTDC network, a study of the co-ordinative operation of different DC CB technologies is required. In this thesis, two typical types of DC CBs are modelled in detail and implemented in a 4-terminal MTDC network in PSCAD environment, by considering operation time, interruption capability and interruption characteristics. The obtained results are used for DC CB’s selection optimization methodology for the future MTDC networks. Similarly, a scaled model of DC CB has to be analysed in terms of its interruption capability in MTDC network considering various scenarios. Therefore, in this master thesis, technical performance of DC CB technologies is conducted for a test and multiterminal dc network in EMT based software environment.The DC CB is the key to unlock the reliable operation of a Multi-terminal direct current network, whereas fast, effective and accurate models are frequently needed for system-level studies. Due to higher subsystem components in DC CB, a detailed DC CB model creates a bottleneck in the network analysis. This thesis also proposes and compares, an average model with a detailed model of Voltage source converter Assisted Resonant Current (VARC) and Mechanical DC CB in MTDC Network in terms of their performance and computation time for two typical simulation cases. The average and detailed model is modelled and simulated on the PSCAD/EMTDC electromagnetic transient platform. Decisively, this thesis concludes by presenting an accurate response of the average model during the fast transient event, showing additional computational advantage.<br/
Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease
No full textThe endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD). However, the association between CB1 alterations and the development of AD neuropathology is unclear and often contradictory. In this study, brain CB1 mRNA and CB1 protein levels were analyzed in 3 × Tg-AD mice and compared to wild-type littermates at 2, 6 and 12 months of age, using in-situ hybridization and immunohistochemistry, respectively. Semiquantitative analysis of CB1 expression focused on the prefrontal cortex (PFC), prelimbic cortex, dorsal hippocampus (DH), basolateral amygdala complex (BLA), and ventral hippocampus (VH), all areas with high CB1 densities that are strongly affected by neuropathology in 3 × Tg-AD mice. At 2 months of age, there was no change in CB1 mRNA and protein levels in 3 × Tg-AD mice compared to Non-Tg mice in all brain areas analyzed. However, at 6 and 12 months of age, CB1 mRNA levels were significantly higher in PFC, DH, and BLA, and lower in VH in 3 × Tg-AD mice compared to wild-type littermates. CB1 immunohistochemistry revealed that CB1 protein expression was unchanged in 3 × Tg-AD at 2 and 6 months of age, while a significant decrease in CB1 receptor immunoreactivity was detected in the BLA and DH of 12-month-old 3 × Tg-AD mice, with no sign of alteration in other brain areas. The altered CB1 levels appear, rather, to be age-and/or pathology-dependent, indicating an involvement of the endocannabinoid system in AD pathology and supporting the ECS as a potential novel therapeutic target for treatment of AD
L’Erbario Estense dell’Archivio di Stato di Modena: progetto di studio delle piante più notevoli dal lato storico, botanico e terapeutico
No full textL’Erbario Estense, conservato nell’Archivio di Stato di Modena, risale alla seconda metà del 1500 ed è pertanto fra i più antichi d’Europa. Consta di 146 fogli, su cui sono incollati 180 exsiccata, di solito consistenti in una singola parte della pianta (una foglia, un ramo fiorifero ecc.); le filigrane dei fogli e le calligrafie delle scritte presenti presso i campioni sono talvolta diverse fra loro. Fu preparato a Ferrara, nel contesto dello Studio e della Corte estense, culturalmente assai vivace e frequentato da eminenti botanici europei, quali Amato Lusitano e John Falconer. Non si conosce l’autore dell’erbario, che potrebbe anche essere opera di più mani.
L’erbario fu studiato per la prima volta da Jules Camus e Otto Penzig (1885); tuttavia, non ha mai goduto di una fama paragonabile a quella degli erbari coevi (Aldrovandi, Cesalpino ecc.). Il progetto di studio qui presentato mira a esaminare i campioni delle specie più notevoli dal lato storico, botanico e farmaceutico, per ottenere un’identificazione certa e notizie sulla loro storia. Un primo passo è già stato compiuto in questo senso, grazie all’analisi del campione n. 120, denominato «spigo nardo» nella scritta riportata accanto al campione stesso, riconducibile con buona probabilità a Nardostachys jatamansi (D. Don) DC., specie assai nota fin dall’antichità per le sue qualità officinali e cosmetiche. In parallelo, sono in corso anche alcune ricerche per cercare di stabilire l’autore dell’erbario
The characteristics of the polish CB-language
No full textThe paper analyzes the language used by drivers on the Citizens’ Band radio (CB radio). The
users of the radio communicate only in speech, their communication is highly pragmatic and
based on partnership. The utterances alternate between formal and informal ones, which
determines the range and register of vocabulary. Drivers often use diminutives and polite
addresses thus creating the atmosphere of mutual respect and cordiality, which can be
comforting and reassuring for strangers who happen to establish a casual contact. The specific
language used on the CB radio fulfils two basic functions: it creates a sense of community
among drivers and protects the information passed on as warnings. At the end of the paper,
the author appends a comprehensive glossary of the CB language
Supplementary Data from 5-Fluorouracil Enhances the Antitumor Activity of the Glutaminase Inhibitor CB-839 against <i>PIK3CA</i>-Mutant Colorectal Cancers
No full textSupplementary Figures 1-6 and Tables 1-3. Figure S1. PIK3CA mutant cells are more sensitive to a glutaminase inhibitor CB-839 than their WT counterparts. Figure S2. CB-839 enhances 5-FU tumor inhibitory effect in PIK3CA mutant CRC. Figure S3. Genes and pathways that are up-regulated in PIK3CA mutant cells after glutamine deprivation. Figure S4. Characterization of Nrf2 and its targets in CRC cells. Figure S5. CB-839 and 5-FU combinational treatment induces more DNA damage. Figure S6. Phase I clinical trial. Table S1: Patient Baseline Characteristics. Table S2. Patient information. Table S3. Treatment Related Adverse Events (all grade 3/4 AEs and grade 1/2 AEs seen in {greater than or equal to} 10% of patients).</p
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