102,515 research outputs found
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Warren G. Harding letter to Adolphe Danziger, February 21, 1921
No full textIn this letter dated February 21, 1921, President-elect Warren G. Harding writes to Adolphe Danziger, a Jewish scholar, lawyer and author, to thank him for the poem he wrote honoring Harding titled "Within the Storm."
This letter is part of the Warren G. Harding Papers (MSS 345). This collection includes correspondence, business records, and other materials documenting Harding’s business career as owner and editor-in-chief of The Daily Marion Star, as well as the various stages of his political career. A significant portion of the collection, and what’s available on Ohio Memory, highlights his 1920 presidential campaign, spanning just before publicly announcing his candidacy to handily defeating Ohio Governor James M. Cox in the election. Correspondents include both Ohio and national businessmen, political figures, and ordinary citizens writing with questions, support, congratulatory notes, and campaign advice. Some of the most interesting insights into the tumultuous political climate in the U.S., the extreme factionalism within the Republican Party in Ohio, and Harding’s campaign strategies are described in letters between Harding and his campaign manager, Harry M. Daugherty. Some of the topics addressed include women’s suffrage, Prohibition, the League of Nations, African American representation and issues, and lingering peace negotiations following World War I
Wissenschaftliche Bibliographie Hilarion G. Petzold 1958 – 2014 mit Anhang von 2007 als Einführung
No full textDieses Archiv enthält die Gesamtbiliograpie der Werke des Autors bis Dez. 2013 nebst einiger Texte „Über H. G. Petzold“ und einen Anhang mit einer Einführung in die Struktur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author up to Dec. 2013 and some texts about H. G. Petzold, moreover an appendix with an introduction to the structure of the work in its epistemological structure and composition as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2014-petzold-h-g-2014-wissenschaftliche-gesamtbibliographie-1958-2014/peerReviewedpublishedVersio
G-Rank: Unsupervised Continuous Learn-to-Rank for Edge Devices in a P2P Network
No full textRanking algorithms in traditional search engines are powered by enormous training data sets that are meticulously engineered and curated by a centralized entity. Decentralized peer-to-peer (p2p) networks such as torrenting applications and Web3 protocols deliberately eschew centralized databases and computational architectures when designing services and features. As such, robust search-and-rank algorithms designed for such domains must be engineered specifically for decentralized networks, and must be lightweight enough to operate on consumer-grade personal devices such as a smartphone or laptop computer. We introduce G-Rank, an unsupervised ranking algorithm designed exclusively for decentralized networks. We demonstrate that accurate, relevant ranking results can be achieved in fully decentralized networks without any centralized data aggregation, feature engineering, or model training. Furthermore, we show that such results are obtainable with minimal data preprocessing and computational overhead, and can still return highly relevant results even when a user’s device is disconnected from the network. G-Rank is highly modular in design, is not limited to categorical data, and can be implemented in a variety of domains with minimal modification. The results herein show that unsupervised ranking models designed for decentralized p2p networks are not only viable, but worthy of further research.https://github.com/awrgold/G-RankComputer Scienc
Design and synthesis of G-quadruplex selective macrocyclic polyoxazoles
No full textNucleic acid sequences that can form stable G-quadruplex structures have been implicated in numerous biological functions. G-quadruplexes are thought to play a vital role in telomere maintenance and regulating gene expression. The majority of cancer cells over-express telomerase, an enzyme that bypasses the aging process by adding telomeric repeats to chromosome ends. Also about 65% of oncogenes have a potential G-quadruplex forming sequence in their promoter region. It is believed that stabilized G-quadruplexes can indirectly inhibit telomerase and decrease oncogene expression resulting in cancer cell death. These observations have led to the development of small molecules that stabilize G-quadruplexes as a new class of anticancer agents. Several research groups have developed such molecules but most lack selectivity over other forms of DNA. A unique molecule among these is telomestatin, a macrocyclic natural product with 70-fold selectivity for G-quadruplex DNA over duplex and low micromolar cytotoxicity. Although telomestatin has exceptional activity, it is difficult to synthesize and hard to formulate because it lacks water-solubilizing groups. Initial studies utilized telomestatin as a lead structure to develop a novel class of macrocyclic hexaoxazoles with the most active compound being HXDV. It was shown to stabilize G-quadruplex DNA with no detectable interaction with duplex DNA and had comparable cytotoxic activity to telomestatin. Unfortunately, HXDV had limited aqueous solubility and required a lengthy synthesis. Efforts to modify the structure of HXDV to enhance water solubility and simplify the synthetic process are described in this dissertation. While this was generally successful, a shorter synthesis was needed to rapidly assess structure-activity relationships. This led to the development of a second class of compounds called macrocyclic pyridyl polyoxazoles (PyPX). These compounds utilize a molecular scaffold that is readily accessed in few synthetic steps to form numerous macrocyclic analogs. This enables quick assessment of structure-activity relationships. Several members of this class are excellent G-quadruplex stabilizers and do not interact with duplex DNA. These compounds also possess low nanomolar cytotoxicity and one was active in an in vivo bioassay. Structure-activity studies utilizing the PyPX scaffold continue in an effort to identify clinical candidates.Ph.D.Includes bibliographical referencesIncludes vitaby Suzanne G. Rzucze
Pensar la violencia desde G. Deleuze
No full textEl artículo reflexiona sobre el fenómeno de la violencia en nuestras sociedades tardomodernas. En primer lugar, critica la concepción ilustrada de la violencia, según la cual ésta es siempre una desviación de la razón, es decir, una "sinrazón". En segundo lugar, el autor sostiene que la comprensión de la violencia debe hacerse desde el "pensamiento de la diferencia". Desde esta última perspectiva, la violencia es el resultado del imperio de la "lógica oposicional" o "lógica binaria", la cual sustituye a la relación diferencial de carácter rizomático. Se recurre, fundamentalmente, al pensamiento de G. Deleuze, matizando el fenómeno de la violencia como "necedad", "geometría de Estado" e "incapacidad para ser afectado".The article reflects on the phenomenon of violence in our late modern societies. First, criticizes the Enlightenment conception of violence, that it is always a deviation of reason, ie a "unreason". Secondly, the author argues that the understanding of violence must be from the "thought of difference". From the latter perspective, violence is the result of the rule of "oppositional logic" or "binary logic" which replaces the differential relation of rhizomatic character. It basically resorts to thoughts of G. Deleuze, qualifying the phenomenon of violence as "stupidity", "geometry of State" and "incapacity to be affected"
Comment on “Application of (G′/G)-expansion method to travelling-wave solutions of three nonlinear evolution equation" [Comput Fluids 2010;39;1957-63]
No full textIn a recent paper [Abazari R. Application of (G′ G )-expansion method to travelling wave solutions of three nonlinear evolution equation. Computers & Fluids 2010;39:1957–1963], the (G′/G)-expansion method was used to find travelling-wave solutions to three nonlinear evolution equations that arise in the mathematical modelling of fluids. The author claimed that the method delivers more general forms of solution than other methods. In this note we point out that not only is this claim false but that the delivered solutions are cumbersome and misleading. The extended tanh-function expansion method, for example, is not only entirely equivalent to the (G′/G)-expansion method but is more efficient and user-friendly, and delivers solutions in a compact and elegant form
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
Interview of Andres G. Guerrero
No full textAndres G. Guerrero, author of "A Chicano Theology," reminisces about his childhood in east Texas, his family and his education, and describes his personal evolution and awakening as a community organizer and teacher working with the poor in the Saginaw, MI Diocese. Guerrero, who holds a doctorate in theology, says that most religions are Euro-centric and do not account for a "native way" of thinking and he challenges all religious institutions to simply "teach love". Guerrero also discusses his book and suggests areas for further study in leadership, organizing, and managing power for the benefit of the entire Chicano Latino community and not just the few. Guerrero is interviewed by Michigan State University Librarian Diana Rivera for the "Mexican Voices - Michigan Lives" oral history series
Evolution of the G+C content frontier in the rat cytomegalovirus genome
No full textWithin the 230138 bp of the rat cytomegalovirus (RCMV) genome, the G+C content changes abruptly at position 142644, constituting a G+C content frontier. To the left of this point, overall G+C content is 69.2%, and to the right it is only 47.6%. A region of extremely low G+C content (33.8%) is found in the 5 kb immediately to the right of the frontier, in which there are no predicted coding sequences. To the right of position 147501, the G+C content rises and predicted coding sequences reappear. However, these genes are much shorter (average 848bp, 50% G+C) than those in the left two-thirds of the genome (average 1462bp, 70% G+C). Whole genome alignment of several viruses indicates that the initial ultra-low G+C region appeared in the common ancestor of the genera Cytomegalovirus and Muromegalovirus, and that the lowering of G+C in the right third has been a subsequent process in the lineage leading to RCMV. The left two-thirds of RCMV has stop codon occurrences at 67.5% of their expected level, based on a modified Markov chain model of stop codon distribution, and the corresponding figure for the right third is 78%. Therefore, despite heavy mutation pressure, selective constraint has operated in the right third of the RCMV genome to maintain a degree of gene length unusual for such low G+C sequences
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