1,551 research outputs found
Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle
No full textIn prion diseases (PrDs), aggregates of misfolded prion protein (PrPSc) accumulate not only in the brain but also in extraneural organs. This raises the question whether prion-specific pathologies arise also extraneurally. Here we sequenced mRNA transcripts in skeletal muscle, spleen and blood of prion-inoculated mice at eight timepoints during disease progression. We detected gene-expression changes in all three organs, with skeletal muscle showing the most consistent alterations. The glutamate-ammonia ligase (GLUL) gene exhibited uniform upregulation in skeletal muscles of mice infected with three distinct scrapie prion strains (RML, ME7, and 22L) and in victims of human sporadic Creutzfeldt-Jakob disease. GLUL dysregulation was accompanied by changes in glutamate/glutamine metabolism, leading to reduced glutamate levels in skeletal muscle. None of these changes were observed in skeletal muscle of humans with amyotrophic lateral sclerosis, Alzheimer’s disease, or dementia with Lewy bodies, suggesting that they are specific to prion diseases. These findings reveal an unexpected metabolic dimension of prion infections and point to a potential role for GLUL dysregulation in the glutamate/glutamine metabolism in prion-affected skeletal muscle
Karl D. Darmstaedter Collection
No full textCorrespondence and autographs, including letters from former residents of Mannheim, as well as Rabbi Joseph Carlebach, Rabbi Jacob Hoffman, Richard Beer-Hofmann, Jacob Rosenheim, Felix Theilhaber, Fritz von Unruh, and Karl Wolfskehl.Clippings, notes, photos of synagogues and cemeteries, organizational records, and official and private documents about Jews in southwestern Germany, especially in Baden and the Palatinate including material from Alsberg an der Bergstrasse, Birkenau, Ettenheim, Grosbliederstroff, Karlsruhe, Königswart, Ladenburg, Memmingen, Mannheim, Neckarbischofsheim, Sugenheim, Weinheim, Worms, and Zwingenberg, as well as Amsterdam and Prague, from the eighteenth through the twentieth century.Material on the Ephraim Deinard collection at the Smithsonian Institution in Washington, D.C.Lists of refugees deported from Gurs and Rivesaltes internment camps; correspondence with former residents of Mannheim interned in Gurs and Récébédon, including Eugen Neter.The following places are mentioned in this collection:Alsberg/Bergstrasse; Amsterdam; Baden; Berlin; Berlin-Spandau; Birkenau (Concentration or internment camps); Boettigheim; Czechoslovakia; Dachau (Concentration or internment camps); Ettenheim; Fuerth; Grosbliederstroff; Gurs (Concentration or internment camps); Karlsruhe; Koenigswart; Ladenburg; Mannheim; Memmingen; Muehlhausen; Neckarbischofsheim; Palatinate; Poland; Prague; Recebedou (concentration or internment camps); Rivesaltes (internment camp); Sugenheim; Switzerland; Weinheim; Worms; ZwingenbergThe following individuals are mentioned in this collection:Baer, Max; Beer-Hofmann, Richard; Bialik, Chaim Nachman; Bin Gorion, Micha (Berdyczewski, Micha); Carlebach, Joseph; Cremieux, Adolphe; Deinard, Ephraim; Deutschlaender, Leo; Eisenstadt, Judah David; Eisenstein, Judah David; Finkelstein, Louis; Frank, Ludwig; Ginsburger, W.; Goslar, Hans; Greilsheimer, J.; Heilbronn, Siegfried; Herzl, Theodor; Hoffman, Jacob; Hoffman, Jacob; Kassewitz, Sigmund; Kussewitz, S.; Lamm, Louis; Liptzin, Sol; Loeb, Ferdinand; Loewe, Heinrich; Mosbacher, Leopold; Neter, Eugen; Neter, Mia; Neter, Richard; Pinkuss, Dr.; Posner, Alfred; Rosenheim, Jacob; Rothschild, Lehrer; Sabbatai Zvi; Schachnowitz, S.; Schnitzler, Arthur; Scholem, Gershom; Schwarzschild, Ignaz; Simon, Leopold; Sobernheim, Moritz; Theilhaber, Felix; Unna, Isak; Unruh, Fritz von; Wise, Stephen; Wolfskehl, Karl; Wuerzburger, HedwigBorn in Birkenau on September 25, 1892, Karl D.Darmstaedter emigrated to the United States via the Netherlands in 1939-1940. He settled in Washington, D.C., and was active as an author, poet, and professor of German. He died in 1984.12-page inventory.Carlebach, Rabbiner Joseph. "Ritualmord?" Sonderbeilage zum Israelitische Familienblatt, 6/14/34. Moved from collection to library. (BM 717 A2 C37)Last Folder, of Plate Glass Negatives, not on MicrofilmPhotographs removed to Photograph CollectiondigitizedMarriage; Holocaust; Holidays ; Orthodox Judaism ; Jewish law ; Prayers ; Blood accusation; Ritual slaughter; Burial societies; Deportations; Memorial books; Synagogue architecture; Prayer-books; Poems; Cemeteries; Voyages and travelsGurs ; Dachau ; Recebedou ; Rivesaltes ; Birkena
Memo from Captain Albert H. Moffitt, Jr., by order of Colonel Bendetsen to staff of the Wartime Civil Control Administration, May 3, 1942
No full textMemo from Albert H. Moffitt by order of Karl R. Bendetsen to staff of the Wartime Civil Control Administration, announcing the arrival of Major Lloyd F. Harris to serve as Liaison Officer for the Northern California Sector, replacing Lieutenant Colonel L. E. Rolfo.Consists of various materials collected and maintained by William J. Mountin, gathered in the course of his work in the Statistical Branch of the Wartime Civilian Control Administration (WCCA). Includes War Relocation Authority (WRA) and WCCA correspondence and memos concerning the administration of the office in San Francisco; copies of statistical reports and bulletins, including those compiled by the U.S. Census Bureau; sample forms, reports, maps, bulletins, and Civilian Exclusion Orders and Instruction broadsides; ephemeral publications of various official organizations concerned with the administration of the U.S. Army Western Defense Command office, including directories and organizational charts; and clippings
Memo from Captain Albert H. Moffitt, Jr., by order of Colonel Bendetsen to staff of the Wartime Civil Control Administration, May 1, 1942
No full textMemo from Albert H. Moffitt by order of Karl R. Bendetsen to staff of the Wartime Civil Control Administration, containing an assignment of personnel to duty within the Evacuation Operations Division.Consists of various materials collected and maintained by William J. Mountin, gathered in the course of his work in the Statistical Branch of the Wartime Civilian Control Administration (WCCA). Includes War Relocation Authority (WRA) and WCCA correspondence and memos concerning the administration of the office in San Francisco; copies of statistical reports and bulletins, including those compiled by the U.S. Census Bureau; sample forms, reports, maps, bulletins, and Civilian Exclusion Orders and Instruction broadsides; ephemeral publications of various official organizations concerned with the administration of the U.S. Army Western Defense Command office, including directories and organizational charts; and clippings
Administrative order (United States. Wartime Civil Control Administration), number 3, revised (May 1, 1942)
No full textAdministrative order number 3 regarding routine administrative procedures of the Wartime Civil Command Administration and the Civil Affairs Division. Document signed by Karl R. Bendetsen, and contains an attached revision dated May 1, 1942.Consists of various materials collected and maintained by William J. Mountin, gathered in the course of his work in the Statistical Branch of the Wartime Civilian Control Administration (WCCA). Includes War Relocation Authority (WRA) and WCCA correspondence and memos concerning the administration of the office in San Francisco; copies of statistical reports and bulletins, including those compiled by the U.S. Census Bureau; sample forms, reports, maps, bulletins, and Civilian Exclusion Orders and Instruction broadsides; ephemeral publications of various official organizations concerned with the administration of the U.S. Army Western Defense Command office, including directories and organizational charts; and clippings
Memo from Colonel Karl R. Bendetsen, Assistant Chief of Staff, Civil Affairs Division of the Wartime Civil Control Administration, to all assembly and reception center managers, April 29, 1942
No full textMemo to "all assembly and reception center managers from Karl R. Bendetsen regarding "instruction covering press relation and releases."Consists of various materials collected and maintained by William J. Mountin, gathered in the course of his work in the Statistical Branch of the Wartime Civilian Control Administration (WCCA). Includes War Relocation Authority (WRA) and WCCA correspondence and memos concerning the administration of the office in San Francisco; copies of statistical reports and bulletins, including those compiled by the U.S. Census Bureau; sample forms, reports, maps, bulletins, and Civilian Exclusion Orders and Instruction broadsides; ephemeral publications of various official organizations concerned with the administration of the U.S. Army Western Defense Command office, including directories and organizational charts; and clippings
WHAT'S IN A TEXT?RECONSTRUCTING THE ROMAN REPUBLIC– APPROACHES AND AIMS ONCE AGAIN
No full textAbstract
In this rejoinder to Michael Crawford's critical (re)view (pp. 105–14) of Karl-J. Hölkeskamp's book Reconstructing the Roman Republic: An Ancient Political Culture and Modern Research (Princeton 2010), the author answers concrete criticisms, restates his most important positions, perspectives, and proposals on the topic, and gives a survey of possible theories and models, methodological approaches, and conceptual frameworks discussed at length in the book: concepts of ‘politics’, ‘policies’etc. and the overcoming of traditional ‘constitutionalist’ and ‘factionalist’ approaches in recent research; the concept of ‘political culture’ as a catalyst for a change of paradigm and the new look at rituals and other symbolic dimensions of politics; ‘culturalist’, sociological and comparative approaches to ‘city-statehood’ as well as some concrete controversial issues of his so-called ‘elitist’ view of the Roman republic, its political class and the foundations of its self-construction, legitimization, and successful reproduction.</jats:p
Administrative order (United States. Wartime Civil Control Administration), number 5
No full textAdministrative order number 5 with subject "liaison with Department of Justice regarding enforcement under Public Law 503." Document is singed by Karl R. Bendetsen and lists an enclosure of memorandum for Assistant Secretary of War.Consists of various materials collected and maintained by William J. Mountin, gathered in the course of his work in the Statistical Branch of the Wartime Civilian Control Administration (WCCA). Includes War Relocation Authority (WRA) and WCCA correspondence and memos concerning the administration of the office in San Francisco; copies of statistical reports and bulletins, including those compiled by the U.S. Census Bureau; sample forms, reports, maps, bulletins, and Civilian Exclusion Orders and Instruction broadsides; ephemeral publications of various official organizations concerned with the administration of the U.S. Army Western Defense Command office, including directories and organizational charts; and clippings
"A Supertemporal Continuum": Christocentric Trinity and the Dialectical Reenvisioning of Divine Freedom in Bulgakov and Barth
Full text linkThis is the author accepted manuscript. The final version is available from Fortress Press via the link in this record.The diaspora of scholars exiled from Russia in 1922 offered something vital for both Russian Orthodoxy and for ecumenical dialogue. Under new conditions, liberated from scholastic academic discourse, and living and writing in new languages, the scholars set out to reinterpret their traditions and to introduce Russian Orthodoxy to the West. Yet, relatively few have considered the works of these exiles, particularly insofar as they act as critical and constructive conversation partners. This project expands upon the relatively limited conversation between such thinkers with the most significant Protestant theologian of the last century, Karl Barth. Through the topic and in the spirit of sobornost, this project charters such conversation. The body of Russian theological scholarship guided by sobornost challenges Barth, helping us to draw out necessary criticism while leading us toward unexpected insight, and vice versa. Going forward, this volume demonstrates that there is space not only for disagreement and criticism, but also for constructive theological dialogue that generates novel and creative scholarship. Accordingly, this collection will not only illuminate but also stimulate interesting and important discussions for those engaged in the study of Karl Barth’s corpus, in the Orthodox tradition, and in the ecumenical discourse between East and West
Can reforming global institutions help developing countries share more in the benefits from globalization?
Full text linkGlobalization could significantly expand trade, international investment, and technological advances, but the gains from global integration have been unevenly distributed across and within nations. Greater global interdependence has also brought greater macroeconomic volatility, resulting in several serious financial crises in the second half of the 1990s. The global matrix of Bretton Woods and United Nations institutions that developed starting in the 1940s, formed under a different balance of power, in a world of fixed exchange rates and limited capital mobility. Since the 1960s regional financial institutions have emerged because of the greater autonomy of different regions and the greater financial needs of development. The author reviews different proposals for reform of the international financial institutions and changes in the roles of the International Monetary Fund (IMF) and the World Bank. He highlights the implications for developing countries of (1) Policy conditionality. (2) The countercyclical role of multilaterals'lending. (3) Greater lending to middle-income than to low-income developing countries. (3) Access to liquidity at times of crisis. (4) Mechanisms for giving low-income countries a greater voice in IMF and World Bank decisionmaking. The author streses the overlapping responsibilities of the Bretton Woods and regional financial institutions and the need to reassess the allocation of responsibilities and to develop better coordination mechanisms between these institutions. Those designing institutional reform must consider the corporate capabilities of each type of institution. The corporate cultures of global and regional institutions differ. So does the kind of knowledge they generate and disseminate, and so do patterns of interactions with, and mechanisms for representation of, client countries.Finally, the author calls attention to the need to harmonize national and global growth-oriented policies in a way that reduces volatility and promotes social equity.Environmental Economics&Policies,Governance Indicators,Financial Intermediation,Economic Theory&Research,Banks&Banking Reform
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