133,069 research outputs found
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
11-0367 CITY OF N. RICHLAND HILLS, TEX. v. FRIEND
No full text11-0367 City of North Richland Hills v. Laura Friend and Luther Friend from Tarrant County and the Second District Court of Appeals, Fort Worth For petitioner: Fredrick Wayne “Fritz” Quast, Fort Worth For respondents: Darrell L. Keith, Fort Worth For ami
Emergence and Collapse of Peace with Friend Selection Strategies
No full textA society consisting of agents who can freely choose to attack or not to attack others inevitably evolves into a battling society (a \'war of all against all\'). We investigated whether strategies based on C. Schmitt\'s concept of the political, the distinction of a friend and an enemy, lead to the emergence and collapse of social order. Especially, we propose \'friend selection strategies\' (FSSs), one of which we called the \'us-TFT\' (tit for tat) strategy, which requires an agent to regard one who did not attack him or his \'friends\' as a \'friend\'. We carried out evolutionary simulations on an artificial society consisting of FSS agents. As a result, we found that the us-TFT results in a peaceful society with the emergence of an us-TFT community. In addition, we found that the collapse of a peaceful society is triggered by another FSS strategy called a \'coward\'.Community, Carl Schmitt, a Friend and an Enemy, Tit for Tat, Coward, Evolutionary Simulation
Preparation, characterization, and structural systematics of diphosphane and diarsane complexes of indium(III) halides
No full textThe ligands o-C6H4(PMe2)2 and o-C6H4(AsMe2)2 (L?L) react with anhydrous InX3 (X = Cl, Br, or I) in a 2:1 InX3/ligand ratio to form [InX2(L?L)][InX4] containing distorted tetrahedral cations, established by X-ray crystal structures for L?L = o-C6H4(PMe2)2 (X = Br or I) and o-C6H4(AsMe2)2 (X = I). IR, Raman, and multinuclear NMR (1H, 31P, 115In) spectroscopy show that these are the only species present in solution in chlorocarbons and in the bulk solids. The products from reactions in a 1:1 or 1:2 molar ratio are more diverse and include the halide-bridged dimers [In2Cl6{o-C6H4(PMe2)2}2] and [In2X6{o-C6H4(AsMe2)2}2] (X = Cl or Br) and the distorted octahedral cation trans-[InBr2{o-C6H4(PMe2)2}2][InBr4]. The neutral complexes partially rearrange in chlorocarbon solution, with multinuclear NMR spectroscopy revealing [InX4]? among other species. The iodo complexes trans-[InI2(L?L)2][InI4(L?L)] contain rare examples of six-coordinate anions, as authenticated by an X-ray crystal structure for L?L = o-C6H4(PMe2)2. Two species of formula [In2Cl5(L?L)2]n[InCl4]n (L?L = o-C6H4(PMe2)2 and o-C6H4(AsMe2)2) were identified crystallographically and contain polymeric cations with six-coordinate indium centers bonded to one chelating L?L and a terminal chlorine, linked by alternating single and double chlorine bridges into chains. The complicated chemistry of InX3 with these two rigid chelates is contrasted with that of the flexible diphosphane Et2P(CH2)2PEt2, which forms [In2Cl6{Et2P(CH2)2PEt2}2], and with more sterically demanding o-C6H4(PPh2)2 (Sigl et al. Eur. J. Inorg. Chem. 1998, 203?210). The results also contrasted with those found for GaX3 with the same ligand
Towards a semantic modeling of learners for social networks
No full textThe Friend of a Friend (FOAF) ontology is a vocabulary for mapping social networks. In this paper we propose an extension to FOAF in order to allow it to model learners and their social networks. We analyse FOAF alongside different learner modeling standards and specifications, and based on this analysis we introduce a taxonomy of the different features found in those models. We then compare the learner models and FOAF against the taxonomy to see how their characteristics have been shaped by their purpose. Based on this we propose extensions to FOAF in order to produce a learner model that is capable of forming the basis of a semantic social network.<br/
When a friend dies the impact can be as traumatic as losing a family member
No full textFirst paragraph: The death of a friend is a loss that most people face at some point in their lives – often many times. But it is a grief that may not be taken seriously by employers, doctors or others. The so-called hierarchy of grief, a scale used to determine who is considered a more legitimate mourner than others, puts family members at the top. For this reason, the death of a close friend can feel shunted to the periphery and has been described as a disenfranchised grief.https://theconversation.com/when-a-friend-dies-the-impact-can-be-as-traumatic-as-losing-a-family-member-11647
Inscribed portrait of Senator George L. Radcliffe.
No full textHandwritten inscription: \u27To my friend Felton M. Johnston with pleasantest of reflections and best of wishes - George L. Radcliffe\u27https://egrove.olemiss.edu/fmjohnston/1081/thumbnail.jp
David L. McCarty Civil War letter
No full textThis collection contains a letter written by David L. McCarty from a camp near Helena, Ark., to his friend Ellen, on March 18, 1863
Portrait of Leslie L. Biffle, Secretary of the Senate.
No full textHandwritten inscription: \u27With best wishes to my warm personal friend, \u27Skeeter\u27 - Leslie L. Biffle\u27https://egrove.olemiss.edu/fmjohnston/1114/thumbnail.jp
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