4,027 research outputs found
Closing the Class Gap in Civic Participation
No full textIn the Margaret Chase Smith essay, Amy Fried discusses the implications of increasing class stratification on civic participation in the United States. She suggests that public schools can play an important role in improving citizen engagement
Coinfection of Schistosoma species with Hepatitis B or Hepatitis C Viruses
No full textAlthough a considerable number of studies have been undertaken to date, it is still controversial as to whether or not coinfection with schistosomiasis increases the susceptibility to or progression from HBV or HCV infection. This review is a closer examination of the key studies conducted on human populations on clinical factors that were published in English between 1975 to January 2015. Our review is mainly based on tables containing the salient information, which are arranged first by study population, country of study, and publication date. We provide further explanation, clarification and discussion in the text. As such, it includes both studies that have been conducted on general populations who are largely asymptomatic for clinical disease (Table 1.2.1), as well as those focusing on special populations, which are usually comprised of clinical patients. These special populations have been presented as follow: subjects with chronic liver disease or related conditions such as cirrhosis, Table 1.3.1; subjects with primary liver cancer, Table 1.3.2; subjects with schistosomiasis, Table 1.3.3; subjects with acute or chronic hepatitis resulting from Hepatitis B virus, Table 1.3.4; and, subjects with Hepatitis C virus, Table 1.3.5. We have presented studies that compared two mono-infected groups with one that is coinfected separately in Table 1.4, as these offer us the best basis from which to evaluate if any synergistic effects accompany coinfection.
A number of factors contributed to the results reported in our tables. These included, but are not limited to: subject selection (i.e., asymptomatic cases typically drawn from the general population vs. subjects presenting to a hospital or clinic with clinical disease); study design, which directly impacts our ability to infer causality (i.e., case series, cross-sectional, case control, cohort study); use and choice of control population (i.e., apparently healthy subjects vs. other hospital patients vs. none); sample size, which directly impacts statistical power and can result in a Type II error; geographic area, which may reflect differences in population genetics, public health history, environmental differences or any number of other important factors (i.e., Egypt, Brazil, China); method of testing for schistosomal infections (i.e., stool vs. antibody test); method of testing to determine if advanced schistosomal disease was present (i.e., ultrasound, liver biopsy vs. none); method of serological testing for HBV (i.e., use of HBsAg alone or with other markers or DNA testing); method of serological testing for HCV (i.e., use of anti-HCV alone or with RNA testing); and, year of the study, which reflects among other things, technological improvements between tests as well as possible changes in the frequency of exposure in the populations under study (i.e., use of parenteral anti-schistosomal therapy vs. the oral anti-schistosomal medication).
Despite all these differences, throughout this review we have observed general patterns that seem largely consistent with one another. Studies conducted on general, largely asymptomatic populations tend to support the view that having one of the diseases in question (i.e., schistosomiasis does not necessarily predispose one to becoming coinfected with another (i.e., HBV or HCV). Rather, the probability of becoming coinfected seems most closely associated with modes of transmission for either HBV or HCV in schistosome-endemic areas, such as the past use of parenteral anti-schistosomal therapy or frequent blood transfusion. Once coinfected, however, the clinical course of illness for those with Schistosoma-HBV or Schistosoma-HCV infections are typically much more severe than for mono-infected subjects. The strongest evidence for this was found in the half-dozen or so prospective cohort studies that systematically monitored disease progression in their subjects. With respect to HBV infection, coinfection with Schistosoma prolonged the carriage state and more often resulted in chronic hepatitis with greater cirrhosis as well as higher mortality. Much of the same was also observed with respect to HCV, where coinfection with Schistosoma was associated with a reduced ability to spontaneously resolve the viral infection and more often resulted in rapid fibrosis as well as higher mortality. Furthermore, two of these studies which were fully comparative in nature, support the supposition that there is a synergistic association between Schistosoma-HCV for both liver fibrosis and mortality. Immunological studies, all conducted on HCV, also generally seem to support this.
The results of our research argue for greater primary prevention for both HBV and HCV in Schistosoma-endemic populations. Although no vaccine currently exists for HCV as it does for HBV, additional steps can still be taken to reduce transmission in high risk populations. Greater use of the HBV vaccine is particularly advisable. Finally, additional observational, longitudinal studies conducted on human populations that are fully comparative in nature could help answer some of the remaining questions on both Schistosoma-HBV as well as Schistosoma-HCV coinfections. Some of these include the role of active vs. past schistosomal infections, the role of genetic variants, as well as the effect of coinfection on treatment. Future studies should make a particular effort to use a sufficient sample size to ensure adequate statistical power, which was not often properly considered in many of the studies we reviewed for this paper.Peer reviewe
Maine: Pushed From Away, The Pine Tree State Sways But Does Not Break
No full textChaper 4, on Maine politics. In the book, More Than Blue, More than Yankee: Complexity and Change in New England Politics, Edited by Amy Fried and Ed O\u27Brien, University of Massachusetts Press 2024
Amy Fried Headshot
No full textHeadshot of Amy Friedhttps://digitalcommons.library.umaine.edu/univ_photos/5625/thumbnail.jp
In the Public Interest: A Discussion with Theda Skocpol about the Scholars Strategy Network
No full textLuisa Deprez and Amy Fried interview Theda Skocpol about the Scholars Strategy Network (SSN). The SSN was founded to serve as a bridging organization to help university-based researchers and teachers to get involved in public debates and make their research and ideas accessible to fellow citizens, legislators, and journalists. The SSN includes scholars from many disciplines who share research about public policy issues, elections and civic life, as well as ideas for improvements in legislation and government practices
FIT Authors Talks: "The Miracles" with Amy Lemmon
No full textProfessor and Chair of English and Communication Studies Amy Lemmon reads from and talks about her book The Miracles.With lyricism and grace, Amy Lemmon gives us a worldview to live by. The all-too-familiar “wear of sorrow’s rub” is presented alongside the world’s miracles, including the author’s two children. Fearlessly bridging the gap between tradition and artistic innovation, the author moves us forward with her into the unknown, to entertain new relationships with herself, her children, and the world
American Women Writers: Amy M. Clark
No full textA 2011 conversation with the author Amy M. Clark about her life and the inspiration for her work
Dr. Amy Howard – Faculty Author Interview
No full textAmy Howard, executive director of the Bonner Center for Civic Engagement and associated faculty in American studies, discusses her new book, More Than Shelter: Activism and Community in San Francisco Public Housing, published recently by the University of Minnesota Press. Her research and book looks closely at three public housing projects in San Francisco and brings to light the dramatic measures tenants have taken to create communities that mattered to them
Payton, Amy Louise. "Looking Back" radio show on Paytons book on Georgina Stirling.
No full textCBC freelance broadcaster Cathy Porter talking to author Amy Louise Payton about the life of Georgina Stirling, Soprano Premadonna from Twillingate. Payton talks about her interest in the singer and her book on Stirling; Hiram Silk interviews Amy Louise Payton on the program Looking Back about her book Nightingale of the North about Georgina Stirling. Payton talks about Stirling and the history of the Twillingate area
At war with government : how conservatives weaponized distrust from Goldwater to Trump
No full textPolling shows that since the 1950s Americans\u27 trust in government has fallen dramatically to historically low levels. In At War with Government , the political scientists Amy Fried and Douglas B. Harris reveal that this trend is no accident. Although distrust of authority is deeply rooted in American culture, it is fueled by conservative elites who benefit from it. Since the postwar era conservative leaders have deliberately and strategically undermined faith in the political system for partisan aims. Fried and Harris detail how conservatives have sown distrust to build organizations, win elections, shift power toward institutions that they control, and secure policy victories. They trace this strategy from the Nixon and Reagan years through Gingrich\u27s Contract with America, the Tea Party, and Donald Trump\u27s rise and presidency. Conservatives have promoted a political identity opposed to domestic state action, used racial messages to undermine unity, and cultivated cynicism to build and bolster coalitions. Once in power, they have defunded public services unless they help their constituencies and rolled back regulations, perversely proving the failure of government. Fried and Harris draw on archival sources to document how conservative elites have strategized behind the scenes. With a powerful diagnosis of our polarized era, At War with Government also proposes how we might rebuild trust in government by countering the strategies conservatives have used to weaken it.https://digitalcommons.library.umaine.edu/fac_monographs/1320/thumbnail.jp
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