200 research outputs found
RE: [YPFS] Did 30-day CD Deposits Count as Cash Reserves Prior to 2017?
No full textEmail exchange between Bank of Jamaica affiliate, Janelle Marks, and the author
Ohio plan to prevent heart disease and stroke 2008-2012
No full text2nd ed., 2009.; Title from PDF cover; author statement from p. i of PDF (viewed on May 23, 2011).; "The second edition ... represents the synergistic efforts of the Heart Disease and Stroke Prevention Council (formerly the Cardiovascular Health Alliance and the Ohio Stroke Council), and our internal and external partners across the state"--P. i.; "Created: 3/16/2010 ...; Modified: 3/17/2010 ..."--Document properties screen.; Includes bibliographical references (p. 56-57).; Harvested from the web on 5/23/1
Jazz as a vehicle for elementary music education
No full textThis thesis aims to explore the justification and development of jazz as a vehicle for elementary music education in the United States. A considerable amount of research has been done with jazz education in high school and collegiate settings, but elementary music, particularly from a historical perspective, is a less deliberated area of music education. Examining philosophies commonly used by American music educators establishes the language for the general aims of American elementary music education. Though there were initially objections to jazz in academic settings, it has been gaining acceptance in schools since the late 1940s. Analyses of student performances show evidence of student learning in the jazz idiom. Considering printed sources in conjunction with six interviews with a variety of music educators, the development of jazz education is traced from informal examples at the beginning of jazz itself to Dr. Herb Wong’s formal introduction of jazz to elementary schools in the 1960s. The movement grew through the work of Doug Goodkin and Nancy Ferguson in the 1980s and continues into the present day. Although professional organizations exist to bring these educators together, jazz in elementary schools is still a fragmented area of education that may benefit from the cohesive overview in this thesis.M.A.Includes bibliographical referencesIncludes vitaby Janelle Fis
"Stars of Orange and Black": Memorialization of the Great War in Kalamazoo
No full textii, 61 p.The author discusses how Kalamazoo memorialized four local heroes after World War I and how they represent similar efforts across the country after the war. Colonel Joseph Westnedge's death in 1918 sparked a lively debate in the Kalamazoo Gazette that led to renaming the main north-south street Westnedge Avenue. The author discusses both physical and literary memorials and discusses three other Kalamazoo heroes: Paul Butler, Stillman Jenks, and Howard Pyle
Investigation of the role of CUZD1-STAT5 signaling in mammary gland development and breast cancer
No full textIn the mammary gland, genetic circuits controlled by the hormones, estrogen, progesterone and prolactin (PRL), act in concert with pathways regulated by the epidermal growth factor (EGF) family to control the growth and morphogenesis of this tissue during puberty, pregnancy and lactation. However, the precise molecular mechanisms that integrate these signaling pathways are unclear. In this study, we identifed CUZD1 (CUB and zona pellucida-like domain containing protein- 1) as a novel mediator of PRL signaling in steroid hormone-primed mouse mammary gland and undertook an examination of its role in growth and differentiation of this tissue during pregnancy. CUZD1 expression is markedly induced in steroid-primed mammary epithelial cells in response to PRL treatment. Cuzd1-null mice exhibited a striking impairment in ductal branching and alveolar development during pregnancy, resulting in a subsequent defect in lactation. Interestingly, phosphorylation and activation of STAT5, a transcription factor that mediates PRL signaling, was absent in Cuzd1-null mammary tissue during pregnancy and lactation. We also noted that the expression of epiregulin (EREG), an EGF family growth factor regulated directly by STAT5, is suppressed in Cuzd1-null mammary gland. Protein interaction studies, using flag-tagged CUZD1 expressed in HC11 mouse mammary epithelial cells, revealed that CUZD1 associates with a multi-protein complex containing JAK1/JAK2 and STAT5. Elevated expression of CUZD1 in HC11 cells stimulated phosphorylation and nuclear translocation of STAT5. Chromatin immunoprecipitation experiments indicated that STAT5 and CUZD1 co-occupy the same regulatory region of the Ereg gene. Over-expression of CUZD1 in mammary epithelial HC11 cells induced tumorigenic characteristics, such as substrate independent growth and migration. Furthermore, HC11-Cuzd1 cells formed mammary tumors in vivo following orthotopic injection into nude and Balb/C mice. Mammary tumor cells derived from these animals showed elevated levels of phosphorylation and nuclear localization of STAT5 and consequent activation of the EGF signaling pathway. Blockade of JAK/STAT5 signaling through the use of a STAT5 inhibitor markedly reduced the production of the EGF family growth factors and inhibited PRL-induced tumor cell proliferation in vitro. It also impaired the progression of CUZD1-driven mammary tumorigenesis in vivo. Collectively, our findings suggest that CUZD1 plays an important role in mammary epithelial cell proliferation during mammary gland development and in tumorigenesis by facilitating JAK-STAT5 signaling and subsequent production of growth factors, such as EREG. CUZD1, therefore, emerges as a critical mediator of PRL action that controls mammary alveolar development during pregnancy and lactation and cell proliferation during tumorigenesis.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-05-01The student, Janelle Mapes, accepted the attached license on 2017-04-14 at 15:34.The student, Janelle Mapes, submitted this Dissertation for approval on 2017-04-14 at 15:36.This Dissertation was approved for publication on 2017-04-17 at 08:38.DSpace SAF Submission Ingestion Package generated from Vireo submission #10704 on 2017-08-10 at 14:30:23Made available in DSpace on 2017-08-10T19:51:50Z (GMT). No. of bitstreams: 3
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Previous issue date: 2017-04-17Embargo set by: Colleen Fallaw for item 102612
Lift date: 2019-08-10T21:25:30Z
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College Author Reception Opening Remarks
No full textWelcome to Musselman Library! We are excited to host this celebration of scholarly work with our colleagues in the Provost’s Office.
Thank you to Upscale for kicking this off. Nothing says “party” like acapella. We’re glad you’re here today.
Thank you also to the team of people who made this event possible – to the Library Exhibits and Events Committee, which is chaired beautifully by Kate Martin and also includes Jim Ramos, Lisa McNamee, Donna Skekel, Carolyn Sautter, Susan Pinckey, and Becky Strevig. Becky had a baby a month ago, and Sarah Appedu has been filling in for her and taking care of a multitude of large and small things. Also thanks to Suzanne Gockowski for coordinating with the Provost’s Office and Ryan Nadeau for corralling all these publications that surround us. (excerpt
Europe in the Face of the Black Death
No full text34 p.This paper investigates how medieval Europeans understood the causes and effects of the plague during the mid-fourteenth century. The author identifies three major groups -- the common people, the Church, and men of science and learning—and investigates how this pandemic changed each of these groups
Emergent patterns of diversity and dynamics in natural populations of planktonic Vibrio bacteria
No full textThesis (Ph. D.)--Joint Program in Biological Oceanography (Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering; and, the Woods Hole Oceanographic Institution), 2005.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references.Despite the importance of microorganisms for global and engineering processes, currently lacking is a theoretical framework to describe how the structure of a microbial assemblage translates an environmental condition into a system-level response. Prerequisite to developing such a framework is an understanding of how microbial diversity is partitioned into functional groups of organisms. This thesis has explored the organization and dynamics of microbial diversity within coastal bacterioplankton using the genus Vibrio as a model system. Vibrios are ubiquitous marine bacteria, and include a variety of pathogens. Quantification of Vibrio environmental dynamics by cultivation- independent quantitative PCR and constant denaturant capillary electrophoresis (CDCE), suggests that sea surface temperature is a driving factor in the distribution and abundance of Vibrio populations and that groups of organisms with >98-99% 16S rRNA sequence similarity maintain similar responses to temperature-mediated environmental change. Fine-scale analysis of the genetic structure within one Vibrio population (>99% rRNA similarity to V. splendidus) reveals vast co-occurring genomic diversity. The average concentration of unique genome-types is observed to be 1000-fold lower than the total population size and individual genomes vary in gene content by as much as 1.1 Mb (the equivalent of -1,000 genes). It is proposed that competition between individual genome variants is a weak driver of population genetic structure while stochastic interactions in the water column promote genetic heterogeneity rendering much of the observed diversity in natural populations neutral or effectively neutral.(cont.) Quantification of Vibrio diversity and dynamics is critical to understanding the global factors that determine the prevalence and proliferation of disease-causing strains and their potential contribution to ecosystem-level processes such as organic matter degradation and macronutrient cycling. In addition, an understanding of how diversity is organized in natural assemblages is an important step in the effort to predict the characteristics of microbial systems based upon their component populations.by Janelle Renée Thompson.Ph.D
Modeling coupled physics and biology in ocean straits
No full textThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Includes bibliographical references (p. 149-153).In this thesis, we conduct research toward understanding coupled physics-biology processes in ocean straits. Our focus is on new analytical studies and higher-order simulations of idealized dynamics that are relevant to generic biological processes. The details of coupled physics-biology models are reviewed and an in-depth global equilibrium and local stability analysis of a Nutrient-Phytoplankton-Zooplankton (NPZ) model is performed. This analysis includes parameter studies and methods to evaluate parameter sensitivity, especially in the case where some system parameters are unknown. As an initial step toward investigating the interaction between physics and biology in ocean straits, we develop and verify a new coupled physics-biology model for two-dimensional idealized physical processes including tides and apply it to the San Bernardino Strait in the Philippine Archipelago. This two-dimensional numerical model is created on a structured grid using operator splitting and masking. This model is able to accurately represent biology for various physical flows, including advection-dominated flows over discontinuities, by using the Weighted Essentially Non-Oscillatory (WENO) scheme. The numerical model is verified against a Discontinuous-Galerkin (DG) numerical scheme on an unstructured grid. Several simulations of tidal flow are completed using bathymetry and flow magnitudes comparable to those found in the San Bernardino Strait with different sets of parameters, tidal periods, and levels of diffusion.(cont.) Results are discussed and compared to those of a three-dimensional modeling system. New results include: new methods for analyzing stability, the robust two-dimensional model designed to best represent advection-dominant flows with minimal numerical diffusion and computational time, and a novel technique to initialize three-dimensional biology fields using satellite data. Additionally, application of the two-dimensional model with tidal forcing to the San Bernardino Strait reveals that flow frequencies have strong influence on biology, as very fast oscillations act to stabilize biology in the water column, while slower frequencies provide sufficient transport for increased biological activity.by Lisa Janelle Burton.S.M
The Food First Crusade: Feeding God's Armies Along the Road to the Holy Land
No full text68 p.During the First Crusade, food was of the utmost importance and the need for food ultimately had a major impact on the tactics and outcomes of many of the movements, battles, and sieges in which the armies of Peter the Hermit, Walter Sans-Avoir, and Godfrey of Bouillon were involved. The author reviews the primary sources and describes how the availability of food affected the journey from Europe to the Middle East, shaped the siege of Antioch, and the eventual success in Jerusalem
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