86,542 research outputs found

    Reticulated platelets and immature platelet fraction: Clinical applications and method limitations

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    So-called “reticulated” or “immature platelets,” which are newly released into the circulation, are more reactive than mature platelets, contain more RNA, and can be counted using flow cytometry after staining with thiazole orange or using some fully automated hematology analyzers, albeit with numerical disagreement. This review provides an overview of the state of the art of available technology for measuring immature or reticulated platelets (RP) with preanalytical (time stability, biological variation), analytical (methods, imprecision), and postanalytical (reference range) limitations. We also analyzed the clinical conditions in which immature/RP can be considered a diagnostic or prognostic tool (ie, differential diagnosis of thrombocytopenia, recovery after bone marrow or stem cell transplantation, risk assessment in cardiovascular diseases, response to antiplatelet drugs). They might also be of clinical utility in other settings but with lower evidence. The lack of a specific reference method and universal control material, as well as dependency of results on the measurement technique used, calls for different reference intervals and compromises comparison between clinical studies carried out using different analytical methods. To obviate lack of agreement between methods, more specific RNA dyes are necessary and the impact of the platelet size on the fluorescence signal defined. In the harmonization age, also in nomenclature field, a new definition instead of “reticulated” or “immature” platelets would be useful, and “young platelets” might be a more appropriate definition taking into account both the age and the functionality of this platelet fraction

    Production and use in the lithic industry of the Mousterian in Santa Croce (Bisceglie, Italy)

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    The techno-functional analysis of the lithic assemblages from the Mousterian of Santa Croce has evidenced the complementarity of the two main knapping processes: the laminar débitage, which is characterized by a higher level of standardization, proves to have a more specialized function with respect to the discoid débitage, which is allotted instead to other more diversified activities. It is interesting to note that the opportunistic use of rejuvenation flakes and core residuals responds to the selection of standards, allowing us to assimilate this category to the objectives of discoid production

    I laureati di Padova tra l'impiego, il diniego e il ripiego occupazionale

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    Nella nota si studiano alcuni aspetti di un modello di comportamento sul mercato del lavoro ai laureati e ai diplomati dell’Università di Padova entro 18 mesi dal conseguimento del titolo universitario. Il modello riguarda la ricerca del lavoro, gli eventuali rifiuti e l’accettazione finale di un lavoro che, in certi casi, i laureati/diplomati considerano un ripiego rispetto alle attese maturate conseguendo il titolo universitario. Per l’analisi si utilizzano i dati raccolti con l’indagine longitudinale che l’Università di Padova conduce dal 2000 sui propri laureati e diplomati. Si confronta, in modo particolare, il comportamento dei laureati che già lavoravano prima del conseguimento con quello di chi cerca un primo lavoro dopo il titolo, distinguendo secondo il titolo posseduto, e valutando l’interazione tra il comportamento e le caratteristiche fondamentali dei laureati

    Phoenicians preferred red pigments: micro-Raman investigation on some cosmetics found in Sicily archaeological sites

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    This research was undertaken in the aim of identifying and getting deeper knoowledge into materials and pigments used in cosmestics concerning the contest of the phoenician settlements in Sicilian territory. In fact, about the typologies of cosmetics in use among the Phoenicians, little is known. On this subject, generally references come from bibliographic latin sources: in antiquity, women preferred to paint white their face, red lips and cheeks, yellowish eyes and black to sorround their look (Pliny the Elder, Naturalis Historia; Ovidius, De medicamine faciei feminae). An interesting aspect of this research is that just one paper is known on Punic cosmetics.[1] In the Museo Archeologico Regionale “Antonino Salinas” (Palermo, Sicily) an important collection of unguentaries coming from the town of Selinunte is preserved. Some of them, finely crafted, come from the sanctuary of Demetra Malophoros, some unguentaries come from the acropolis and some more from the necropolis (dating from the 6th to the 5th century b. C). The sacred area, excavated by Cavallari (1818) and Salinas (1903-1905), have provided a great amount of archaeological materials. In the area where once the acropolis rose, the remains show a mixed village, Phoenician and Greek. In this study, the findings from Salinas were considered, as well as some others from the Museum Conte Agostino Pepoli (Trapani), from the Museum Baglio Anselmi (Marsala) and from the museum of Mozia. The number of glass and fictile unguentaries, pyxis and alabastra examined were large: 142 items from Salinas, 210 from Mozia, 14 from Pepoli and 117 from Baglio Anselmi. This research has completed the one carried out on 210 samples from the Museum of Whitaker Foundation from Mozia, a merely phoenician –punic settlement.[2,3] The samples were analyzed by spectroscopic techniques. The IR spectra were acquired with a spectrophotometer VERTEX 70 (Bruker) FT-IR, equipped with a detector deuterium triglycine sulphate (DTGS). The setting parameters were: resolution 4 cm-1, spectral range 4000-600 cm-1, number of scans 32. ATR spectra were recorded using an Elmer Golden-Gate accessory. The micro-Raman spectrometer used in this case was a Labram Model from the Jobin Yvon-Horiba with a spatial resolution of 1 μm and with quick detection ability as a result of the CCD detector 1024x256 pixels cooled to -70°C by the Peltier effect. The spectral resolution was 1 cm-1. The exciting wavelength was the 632.8 nm red line of a He-Ne laser. Generally the samples were presented as inorganic powders of different colors: white, black, blue and red. Though the samples came from different museums, they were considered togheter, since they belonged all to the Phoenician culture and coming from Trapani archaeological sites. The white samples were of two types. The first one was mainly composed of gypsum and anhydrite mixtures (e.g. Inv No 1680, 1663, 1753); the other type (e.g. pyxes Inv N° 1393, 1451) was composed of fully carbonated cerussite, gypsum and litharge. The second kind of cosmetic corresponded to the most famous Greek cosmetic, called psymition, used by women to white the skin. The first type suggested that, for the same use, alternative materials, cheaper and most readily available, could be employed in the past. The black powders, usually used to outline the eyes, were mostly given by carbon obtained from vegetable combustion (e.g. Inv. N° 1566, 2314, 4313) or, sometimes, from bone combustion (animal charcoal) as for the samples Inv. N° 3140, 1761. A single blue powder (Inv N° 42259) was consisted by the famous Egyptian blue (CaCuSi4O10). The love for the red color by Phoenician is evident from the great number of powders of this color, probably used to give color to the cheeks or lips. A wide variety of red minerals was found. In many cases the presence of hematite (e.g. Inv N° 2309, 2689, 4269) was detected. A large number of pink and red powders containing cinnabar (unguentaries Inv N° 1393, 6480-1, 34396) was observed. No frequent and very interesting is in fact the HgS finding powder into alabastra (e.g. Inv. N° 7317/7, 1255), a holder typically used to contain ointments. Another red pigment was identified as red lead (e.g. Inv N° 1606). Finally, a singular discovery was the presence of red lead chromates chrocoite and phoenicochroite, two very rare minerals (e.g. sample Inv. N° 805, 1-98-2, 4386). In fact, they have never been previously attested for cosmetic use, and also rarely attested in paintings before the end of the 18th century when it began to be produced industrially.[4] The high number of Phoenicians samples taken into examination has allowed to understand the typology of raw materials used by the Phoenicians settled in Sicilian contexts. In this study affects the materials heterogeneity used for the make-up, even for example in comparison to the Roman culture, for which there has come a greater number of samples (sites such as Pompeii, Herculaneum and Oplontis were analyzed by our research group),[5-7] but which revealed a palette less extensive and less refined. In particular, this study identified the use of many kind of red pigments, also very rareof mineral origin. References [1] A. Huqet al., Combined, Appl. Phys. A, 2006, 83, 253–256. [2] G. Freguglia, C. Baraldi, M.C. Gamberini, P. Toti, P. Baraldi, PRIN07- Colors and balms in antiquity: from the chemical study to the knowledge of technologies in cosmetics, painting and medicine. Aboca, Sansepolcro (Arezzo, Italy), 2-3th December 2010, p. 50-51. [3] C. Baraldi, G. Freguglia, M.C. Gamberini, P. Baraldi, 5-8th September 2011, RAA2011, Parma, 2011, p. 103-104. [4] R.J.H. Clark. Chimie, 2002, 5, 7–20. [5] P. Baraldi, C. Fagnano, C. Baraldi, M.C. Gamberini, Automata, 2006, 1, 49. [6] M.C.Gamberini, C. Baraldi, F. Palazzoli, E. Ribechini, P. Baraldi, Vib. Spectrosc. 2008, 47/2, 82. [7] E. Van Elslande, M.C. Gamberini, C. Baraldi and P. Walter, An overview of the Raman studies on cosmetic powders from Pompeii, 14-18th September 2009. RAA2009, Bilbao, 2009

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship

    [Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]

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    Newspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.

    ABILITARE la PROFESSIONE DOCENTEEsiti occupazionali e differenziale professionale degli specializzati SSIS Veneto

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    Una ricerca condotta per più di due anni discute i suoi risultati in un volume che assume, per molti aspetti, un rilievo particolare nella ricerca nazionale ed europea sulla professionalità docente. L’indagine, infatti, sconfessa definitivamente il luogo comune che ha voluto caratterizzare le Scuole di Specializzazione degli Insegnanti secondari come “fabbriche di disoccupati”. In 10 anni di esistenza, e con più di 5.000 abilitati dalla SSIS del Veneto, l’81,5% di essi risulta occupato, con più del 31% in ruolo e più del 30% di occupati a tempo determinato. Inoltre l’indagine ha identificato e valutato il differenziale delle competenze fra gli abilitati della Scuola di Specializzazione e gli abilitati che hanno seguito altri percorsi formativi L’interpretazione di questi aspetti permette di comprendere di quanto e come la formazione iniziale incida sul profilo professionale degli insegnanti. Ma l’indagine assume anche un rilievo scientifico perché non tratta di un profilo professionale astratto o accademico dell’insegnante secondario, ma ne definisce il “profilo in esercizio”, collocandolo nel vivo delle trasformazioni profonde che la società della conoscenza oggi impone. E vi giunge rielaborando una metodologia di indagine qualitativa rigorosa che rilegge in modo originale l’impianto della più nota Grounded Theory. Non più vate, né intellettuale triste, l’insegnante riscopre la sua come professione sociale, necessaria anzi indispensabile per una scuola che formi talenti; che amplifica le strutture cognitive e conoscitive dei giovani, abituandoli ad una autonomia senza se e senza ma, capace di navigare entro universi in competizione, con uno sguardo sul mondo proteso ad una mobilità culturale e professionale non provinciale

    Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation

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    The desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters

    John F. Kennedy telegram to Roosevelt

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    Jersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
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