261 research outputs found
Jean-Etienne Liotard und Karoline Luise von Baden: Eine Geschichte der Pastelle
No full textDas Rijksmuseum in Amsterdam beherbergt nach dem Musée d’Art et d’Histoire in Genf die zweitgrößte Sammlung von Pastellgemälden von Jean-Etienne Liotard (1702-1789). Im Hinblick auf die Wiedereröffnung des Museums 2013 wurde im Jahr 2007 ein großes Restaurierungs- und Forschungsprojekt zu den Pastellen initiiert. Die 23 Werke Liotards wurden aus dem Rahmen genommen und dokumentiert; 13 von ihnen wurden restauriert. Um die von Liotard verwendeten Techniken zu rekonstruieren, wurden sowohl Materialproben als auch schriftliche Quellen herangezogen. Neben seinem Traité des principes et règles de la peinture (1781) bilden die erhaltenen Unterlagen seiner einzigen Schülerin in der Pastellmalerei, Karoline Luise von Baden (1723-1783), einen einmaligen und unmittelbaren Beleg für Liotards Praxis. Die Untersuchung der Beziehung zwischen dem Schweizer Künstler und seiner Schülerin führte zur Wiederentdeckung einer Pastellkreidenprobe des Herstellers Bernard-Augustin Stoupan (1701-1775) Zusammenhang mit den technischen Beobachtungen stehen, die an Liotards Pastellen gemacht wurden. Eine eingehende Untersuchung von Liotards Pastelltechniken im Allgemeinen wurde bereits im Jahr 2014 veröffentlicht.Aerospace Structures and MaterialsAerospace Engineerin
Literatur und Emanzipation von Frauen in der Frühromantik : Bettine von Arnim und Karoline von Günderrode
No full textEarly German Romanticism is a period associated in literary analysis with the emancipation of women. Two women writers of the time. Bettine von Arnim and Karoline von Günderrode take up the Romantic view of literature as an emancipating medium. The thesis refers to Romanticism to define the concepts of feminity, literature and emancipation within their historical context. Romanticism attempts a dialogue between the self and its other, and ultimately re-defines woman as the other of the author male. Friedrich Schlegel's novel Lucinde is analysed as a paradigmatic example of the identification of the self through the medium of literature. The writings of Bettine and Karoline have been analysed as early examples of a feminist literary tradition from the standpoint of feminist theory located in the context of modern women's movements. By way of contrast to Romantic literary theory, this feminist literary theory is expressed as a perceived continuity of women's experience. The concept of self-realisation of women authors through literature is examined from the standpoint of understanding literary texts as objectification of self. French feminist criticism is employed to analyse the relation of feminity to systems of representations from the perspective of modern textual practice. It is argued that Bettine's novel is structured around the literary correspondence between herself and Karoline in which they were able to create a "free-space" (Freiraum) in order to discuss their alienation from society. In realising Romanticism's concept of a dialogue. Bettine achieves a new concept of authorship which allows a representation of female desire, as defined by French theory, through a reflection in Karoline as her other. While both women enjoy the advantage of education. Bettine rejects this as an example of male norms. Karoline imitates these norms to emancipate herself. Karoline identifies with the dominant aesthetic norms in her poetry in an attempt at identification. Her letters, on the other hand, reflect a modern experience of discontinuity of self, which she explains as a result of the absence of social practice in the society of her time and the limitations imposed on her as a woman. In the thesis, it is concluded that Karoline's production is difficult to reconcile with either of the above literary theories. Neither Karoline's nor Bettine's literature can be seen as representative of a unified female subject. The medium of literature enables the development of an aesthetic subjectivity, which, it is argued, can be applied to women-specific" (frauenspezifisch) criticism
Constructional change in North American Danish transitional verbs: The case of var født/konfirmeret/gift
No full textThis paper focuses on structural changes in Danish as an immigrant minority language in North America, i.e., language change under the conditions of language contact. Two corpora, the Corpus of North American Danish and the LANCHART corpus (both University of Copenhagen), provide data for a contrastive analysis of auxiliary choice in three verb phrases with transitional biographical verbs (født 'born', konfirmeret 'confirmed' and gift 'married') in North American Danish and modern spoken Danish. Taking a Construction Grammar approach, the author argues that the changes in auxiliary choice, namely the use of var 'was' instead of blev 'became', are the result of cross-linguistic analogy building by the bilingual speakers of North American Danish. The analogical leveling of North American Danish with English leads to constructional change in form and function as well as in frequency and prototype
Erratum: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition (Proceedings of the National Academy of Sciences of the United States of America (2020) 117 (4180-4187) DOI: 10.1073/pnas.1913481117)
No full textCorrection for “The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition,” by Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler, which was first published February 7, 2020; 10.1073/pnas.1913481117 (Proc. Natl. Acad. Sci. U.S.A. 117, 4180-4187). The authors note that Hitoshi Okada should be added to the author list between Karoline E. Kokot and David Hassel. Hitoshi Okada should be credited with providing mice. The corrected author line, affiliation line, and author contributions appear below. The online version has been corrected
Privat eller offentlig? : En studie av kändisbloggens innehåll och läsarnas kommentarer
No full textAbstractTitle: Private or public? A study of the content in the celebrity blog and the readers'comments. (Privat eller offentlig? En studie av kändisbloggens innehåll och läsarnaskommentarer)Number of pages: 36 (37 including enclosure)Author: Karoline FrankTutor: Else NygrenCourse: Media and Communication studies CPeriod: Fall semester 2009University: Uppsala UniversityAim: The aim of this study is to examine the boundary between the private and the public asit is expressed in a number of blogs written by Swedish celebrities.Material/Method: Qualitative textual analysis of four blogs written by Swedishcelebrities.The total amount of analyzed blog posts were 120, since 30 posts from each of theblogs were selected. Also the comments on the blog posts, given by the blog readers wereexamined.Main results: The examined blogs written by celebrities contain both issues that can beconsidered as private and public. The celebrities write about their families, especially theirchildren but, also about their partners as well as they write about things such as movies orrestaurants that they recommend. They also express their emotions relatively often. Only twoof the celebrities wrote something that can be considered to associate with their professionbut, only in one blog post each. Also, two of the celebrities made a treatment against media.Keywords: celebrities, blogs, private, public, Thompson, Giddens, qualitative analysis,comment
HistoryMA_danish_childhood_1999_2011
No full text<p>README</p><p>This is an archive containing items that hold significance for the Danish authors' childhood in the period late 1990's to early 2010's. The authors of the archive are Emma Falbe-Hansen, Andreas Emil Mikkelsen, Asta Bøtkjær Naamansen and Karoline Støjberg Sejersen. The filetypes of the archive are TIFF for pictures and MP3 for sound clips. </p><p>This Zenodo folder contains a media file with the items and a dataset which also includes metadata descriptions and author information. The media file is 164 MB and the dataset is 16.7 KB.</p>
Non-invasive fetal RHD genotyping tests : a systematic review of the quality of reporting of diagnostic accuracy in published studies
No full textArticles reporting the diagnostic accuracy of non-invasive prenatal diagnostic (NIPD) tests for RHD genotyping using fetal material extracted from maternal blood have been published steadily for over a decade. Health care providers in Europe have started to use this technology formanagement of the small number of sensitised pregnancies (ca. 220–600 per annum in the Netherlands, Germany, France and the UK). Scientists and clinicians are also advocating widespread implementation for the far larger number of non-sensitised RhD-negative pregnancies (ca. 34,000–125,000 per annum in the same countries). Largescale, prospective trials are only now underway. Estimates of the technical performance of these tests are currently based on results from small-scale studies, together with formal meta-analysis. The issue of
early assessment of test performance is one faced by many new genetic tests. As part of a wider study we have investigated the quality of reporting of diagnostic accuracy in publications and produced guidelines for future studies.
A systematic search of the literature identified 27 paperswhichmet predefined inclusion criteria. All 27 papers were, first, assessed against an international quality (STARD) checklist for reporting of diagnostic accuracy and, second, against our own in-house NIPD proforma to assess the implications of the quality of reporting specifically for the RhD NIPD test. Authors were found to generally present an optimistic view of NIPD, bearing in mind weaknesses identified in reporting and conduct of their studies and the analysis of results, as evidenced by the low STARD scores. The NIPD proforma identified that specific biases were potentially introduced through selective population sampling and/or failure to report the make-up of the population tested, omission of inconclusive results, inconsistencies in the handling of repeat results on a sample, and lack of adequate controls. These factors would inevitably affect the validity of diagnostic accuracy as reported in individual publications, as well as any subsequent meta-analyses. Together, published reports to date may provide a biased picture of the actual potential of NIPD testing for fetal RHD genotyping. Generalisation of the available evidence on
diagnostic accuracy, especially to large-scale implementation ofNIPD testing of non-sensitisedwomen, will also require that decisionmakers consider further aspects such as test reliability and cost of routine testing in clinical practice. It is recommended that all studies of diagnostic accuracy of NIPD tests adhere to the STARD quality checklist in order to improve reporting, thereby, minimising bias and increasing the comparability of studies. Researchers should also consider specific shortcomings for NIPD and avoid selective participant sampling; report population characteristics; report handling of replicate
sampling as well as their failure rates; and include controls for genotypes tested in the study. Furthermore, meta-analyses should consider the quality, as well as the sample size, of NIPD studies in their analysis. Larger trials, required to produce results that are valid and meaningful for clinical practice, must also adhere to these reporting standards
Business as usual?: the changing structure of “the Italian company” during their Scandinavian tour, 1800–1802
No full textThis article examines and discusses the changes made to “the Italian company” during their Scandinavian tour of 1800 to 1802, changes regarding leadership, membership and repertoire. Prior to 1800, the peripatetic company had performed all over Europe under the direction of Mr Casorti. While in Scandinavia, the company had several local directors. The changes in leadership were a legal necessity, in order to gain access to a Scandinavian entertainment market otherwise closed to foreigners. While in Scandinavia the company offered their usual mix of theatrical performances and artistic feats. In Sweden and Norway however, their programme expanded. The changes in the repertoire were connected with changes in membership, brought about by marriages, births and business partnerships. Whereas changes in leadership constituted an exception to the norm for the company, the author argues that changes to membership and consequentially repertoire were business as usual. Ellen Karoline Gjervan is Associate Professor at Queen Maud University College in Trondheim, Norway. She received her PhD in Theatre Studies at the University of Bergen in 2010. She has published on Henrik Ibsen’s theatrical career, on dramaturgy, and on political theatre and stagecraft of the long eighteenth century
A new fetal RHD genotyping test : costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales
No full textBackground
Postnatal and antenatal anti-D prophylaxis have dramatically reduced maternal sensitisations and cases of rhesus disease in babies born to women with RhD negative blood group. Recent scientific advances mean that non-invasive prenatal diagnosis (NIPD), based on the presence of cell-free fetal DNA in maternal plasma, could be used to target prophylaxis on "at risk" pregnancies where the fetus is RhD positive. This paper provides the first assessment of cost-effectiveness of NIPD-targeted prophylaxis compared to current policies.
Methods
We conducted an economic analysis of NIPD implementation in England and Wales. Two scenarios were considered. Scenario 1 assumed that NIPD will be only used to target antenatal prophylaxis with serology tests continuing to direct post-delivery prophylaxis. In Scenario 2, NIPD would also displace postnatal serology testing if an RhD negative fetus was identified. Costs were estimated from the provider's perspective for both scenarios together with a threshold royalty fee per test. Incremental costs were compared with clinical implications.
Results
The basic cost of an NIPD in-house test is £16.25 per sample (excluding royalty fee). The two-dose antenatal prophylaxis policy recommended by NICE is estimated to cost the NHS £3.37 million each year. The estimated threshold royalty fee is £2.18 and £8.83 for Scenarios 1 and 2 respectively. At a £2.00 royalty fee, mass NIPD testing would produce no saving for Scenario 1 and £507,154 per annum for Scenario 2. Incremental cost-effectiveness analysis indicates that, at a test sensitivity of 99.7% and this royalty fee, NIPD testing in Scenario 2 will generate one additional sensitisation for every £9,190 saved. If a single-dose prophylaxis policy were implemented nationally, as recently recommended by NICE, Scenario 2 savings would fall.
Conclusions
Currently, NIPD testing to target anti-D prophylaxis is unlikely to be sufficiently cost-effective to warrant its large scale introduction in England and Wales. Only minor savings are calculated and, balanced against this, the predicted increase in maternal sensitisations may be unacceptably high. Reliability of NIPD assays still needs to be demonstrated rigorously in different ethnic minority populations. First trimester testing is unlikely to alter this picture significantly although other emerging technologies may
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