2,579 research outputs found
Selected Contributions of Sister Mary Berenice Beck, O.S.F. to Nursing in the United States, 1923-1956
No full textby Sister M. Timothy Costello.Typescript.Thesis (M.S.N.)--Catholic University of America.Bibliography: leaves 44-47.Also available in microfilm
Using clustering of genetic variants in Mendelian randomization to interrogate the causal pathways underlying multimorbidity from a common risk factor
No full textMendelian randomization (MR) is an epidemiological approach that utilizes genetic variants as instrumental variables to estimate the causal effect of an exposure on a health outcome. This paper investigates an MR scenario in which genetic variants aggregate into clusters that identify heterogeneous causal effects. Such variant clusters are likely to emerge if they affect the exposure and outcome via distinct biological pathways. In the multi-outcome MR framework, where a shared exposure causally impacts several disease outcomes simultaneously, these variant clusters can provide insights into the common disease-causing mechanisms underpinning the co-occurrence of multiple long-term conditions, a phenomenon known as multimorbidity. To identify such variant clusters, we adapt the general method of agglomerative hierarchical clustering to multi-sample summary-data MR setup, enabling cluster detection based on variant-specific ratio estimates. Particularly, we tailor the method for multi-outcome MR to aid in elucidating the causal pathways through which a common risk factor contributes to multiple morbidities. We show in simulations that our “MR-AHC” method detects clusters with high accuracy, outperforming the existing methods. We apply the method to investigate the causal effects of high body fat percentage on type 2 diabetes and osteoarthritis, uncovering interconnected cellular processes underlying this multimorbid disease pair
ASO Author Reflections: Re-resection of Positive Bile Duct Margin for Hilar Cholangiocarcinoma
No full textAuthor Reflections: Re-resection of Positive Bile Duct Margin for Hilar Cholangiocarcinom
t-pollington/developments_tau_statistic: First release
No full textCode release archived on Zenodo from the following paper:
@ARTICLE{Pollington2021, author={Pollington, T.M. and Tildesley, M.J. and Hollingsworth, T.D. and Chapman, L.A.C.},
volume = {42},
pages = {100438},
year = {2021},
note = {Towards Spatial Data Science},
issn = {2211-6753},
title={{Developments in statistical inference when assessing spatiotemporal disease clustering with the tau statistic}},
journal={Spatial Statistics},
doi={10.1016/j.spasta.2020.100438},
url = {https://www.sciencedirect.com/science/article/pii/S2211675320300324},
keywords = {Second order dependence, Pointwise confidence interval, Bias corrected accelerated BCa, Percentile confidence interval, Spatial bootstrap, Graphical hypothesis test} }Please contact Timothy M Pollington as corresponding author on [email protected] for any assistance.
TMP, LACC & TDH gratefully acknowledge funding of the NTD Modelling Consortium by the Bill &
Melinda Gates Foundation (BMGF) (grant number OPP1184344) and LACC acknowledges funding of
the SPEAK India consortium by BMGF (grant number OPP1183986). Views, opinions, assumptions
or any other information set out in this article should not be attributed to BMGF or any person
connected with them. TMP's PhD is supported by the Engineering & Physical Sciences Research
Council, Medical Research Council and University of Warwick (grant number EP/L015374/1). TMP
thanks Big Data Institute for hosting him during this work
A web-based screening tool for near-port air quality assessments
No full textAuthor(s): Isakov, Vlad; Barzyk, Timothy M; Smith, Elizabeth R; Arunachalam, Saravanan; Naess, Brian; Venkatram, Akul
Increasing Distributed Generation Penetration using Soft Normally-Open Points
No full textThis paper considers the effects of various voltage control solutions on facilitating an increase in allowable levels of distributed generation installation before voltage violations occur. In particular, the voltage control solution that is focused on is the implementation of `soft' normally-open points (SNOPs), a term which refers to power electronic devices installed in place of a normally-open point in a medium-voltage distribution network which allows for control of real and reactive power flows between each end point of its installation sites. While other benefits of SNOP installation are discussed, the intent of this paper is to determine whether SNOPs are a viable alternative to other voltage control strategies for this particular application. As such, the SNOPs ability to affect the voltage profile along feeders within a distribution system is focused on with other voltage control options used for comparative purposes. Results from studies on multiple network models with varying topologies are presented and a case study which considers economic benefits of increasing feasible DG penetration is also given
Evidence from North Carolina Shows that Immigrant Students with Limited English Have a Very Minor Impact on Native Students' Performance
No full textMuch of the recent concern about undocumented immigration into the U.S. can be linked to the perceived burden that these immigrants may create on the public education system. But is this really the case? Through analyzing detailed information on the performance of students in North Carolina,Timothy M. Diette and Ruth Uwaifo Oyelere find that the presence of students with limited English does have a negative, though small, effect on the math and reading achievement of natives that are male and black. They argue, however, that these effects are so small as not to warrant policy interventions. KEYWORDS: Education, English Language, Immigrants, Impact, Bilingual, Multilingual, and Multicultural Education, Educatio
Evaluating Research Impact through Open Access to Scholarly Communication
No full textScientific research is a competitive business – in order to secure funding, promotion and tenure researchers must demonstrate their work has impact in their field. To maximise impact researchers undertake high priority research, aim to get results first, and publish in the highest impact journals. The Internet now presents a new opportunity to the scholarly author seeking higher impact: s/he can now make their work instantly accessible on the Web through author self-archiving. This growing body of open access literature (coupled with new publishing models that make journals available for-free to the reader) maximises research impact by maximising the number of people who can read it, and making it available sooner. Open access also provides a new opportunity for bibliometric research. This thesis describes the relatively recent phenomenon of open access to research literature, tools that were built to collect and analyse that literature, and the results of analyses of the effect of open access and its effect on author behaviour. It shows that articles self-archived by authors receive between 50-250% more citations, that rapid pre-printing on the Web has dramatically reduced the peak citation rate from over a year to virtually instant and how citation-impact – now widely used for evaluation – can be expanded to include a new web metric of download impact
Timothy Findley's True Fictions: A Conversation at Stone Orchard
No full textHistory, myth, the process of writing and using language, and other works of fiction come together in Timothy Findley's work. The author sees parallels between fiction and history writers: he says that fiction writers are trying to articulate all the versions of reality, all the different points of view. While discussing two of his novels, Famous Last Words and The Wars, he elaborates on the difficulties of ever getting the complete story. The author attempts to land on just the right image, to say: "This is what was in that moment.
Lu et al-An Active Site Loop Toggles Between Conformations to Control Antibiotic Hydrolysis and Inhibition Potency for CTX-M beta-lactamase Drug-Resistance Enzymes
No full textMolecular dynamics simulations trajectories for publication, "An Active Site Loop Toggles Between Conformations to Control Antibiotic Hydrolysis and Inhibition Potency for CTX-M beta-lactamase Drug-Resistance Enzymes"
Shuo Lu1, Liya Hu2, Hanfeng Lin1, Allison Judge2, Paola Rivera1, Murugesan Palaniappan3, Banumathi Sankaran4, Jin Wang1, B.V. Venkataram Prasad2 and Timothy Palzkill1,2*
Department of Pharmacology and Chemical Biology1, Department of Biochemistry and Molecular Biology2, Center for Drug Discovery, Department of Pathology & Immunology3, Baylor College of Medicine, Houston, TX 77030
Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, California, USA4
*Corresponding author: [email protected]</p
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