1,720,979 research outputs found
Horny layer molecular structure: A new theory for hydrophilic molecules free diffusion through the skin
No full textAuthor shows a novel molecular theory capable to describe the passage of hydrophilic molecules and solutes through the horny layer (HL). According to the theory of the "gear wheels" the hydrophilic groups of the intercorneal lipids and especially ceramydes and free fatty acids, components of the lipidic domains, are oriented toward the hydrophilic head of the horny cells, represented by the aminoacidic appendages and humectants substances derived from the epidermal cells proteins catabolism (NMF). This mutual orientation would create aqueous zone placed between the surface of lipids domains surface and the surface of corneocytes so creating aqueous channels in which hydrophilic molecules can be solved in andflow toward the deepest skin layer moved by a mechanism similar to a "gear wheel" device. The molecules and solutes, so, could move for free diffusion or attracted by the aqueous gradient taking place through the adjacent different water content zones. This molecular theory could explain the penetration of high molecular weight hydrophilic molecules such as hyaluronic acid (HA) through the skin, thanks to the capability to hydrate in the water fulfilled channels placed in the space between lipids bi-lamellar domains and horny cells surface. It has been demonstrated that HA can penetrate deeply and quickly through the skin reaching dermal layer. Previous scientfic investigations on the HL structure clarified that skin surface exposure to a prolonged contact with moisture or water solutions produces a dramatic alteration of the HL inducing formation of "aqueous cisternae" and a geometric-structural alteration of the bi-layers inter-corneal lipids. This evidence supports the hypothesis according to which water can penetrate through the shin by mean of hydrophilic paths and then "enlarge" horny cells. Furthermore, this theory would open the path of investigation of new promising and performing new class of skin absorption enhancers even for hydrophilic drugs and cosmetics
Use of coumarin or its hydroxy derivative for the treatment of medium or severe vascular
No full textThe invention concerns the use of coumarin or its hydroxy derivative, preferably 7-hydroxycoumarin, for the preparation of a medicament for the treatment of medium and severe lymphatic and/or vascular edema. The amount of coumarin or its hydroxy derivative is between 35 and 55 mg pro drug unit, preferably of 45 mg. The sublingual pharmaceutical form is described for the first time
Skin side effects of cancer therapy: Etiology and non pharmacological management
No full textPalmar-plantar erythrodysesthesia, dermatitis and folliculitis are skin side effects that frequently occur with chemotherapy. Non pharmacological management includes skin hydratation and the application of substances with anaesthetic and antinflammatory properties
NUTRACEUTICALCOMPOSITIONSCONTAININGPROBIOTICSINANOILYVEHICLE
No full textThe invention concerns nutraceutical compositions based on probiotic microorganisms in an oily vehicle, characterized in that they contain an ascorbyl palmitate salt, a sorbitan ester and silica. Such compositions are advantageous since they allow a high vitality of the microorganisms to be maintained both during storage and after administering and they can be prepared with a process that is simple and cost-effective from the industrial point of view
Composition containing a polyaminoglycoside
No full textA composition comprising: a) a polymeric aminoglycoside and b) a phosphorylated organic acid, wherein the phosphorylated organic acid b) comprises in its structure at least one amine function, wherein - said composition is included in a pharmaceutical formulation in tablet form , capsule or granules comprising: i) an inner core comprising said composition, and ii) a coating of said core a) with gastro-resistant film, which coating is freely soluble in the enteric medium and, in general, at pH > 6; - at a pH between 6.0 and 7.0, when the enteric film dissolves ii) said phosphorylated organic acid b) is in the form of non-quaternary ammonium salt and at the same pH said polymeric aminoglycoside a) is in polycationic form, so that a salt is formed between said phosphorylated organic acid in non-quaternary ammonium salt form and said polymeric aminoglycoside in polycationic form
New Oral Delivery System to Improve Absorption of Berberine: Likely Interaction of Cationized Chitosan with PG-P Pump
No full textNanoemulsion, method for its preparation and use
No full textA nanoemulsion with a micellar size of 20 to 900 nm comprising: a) an active ingredient of interest in the pharmaceutical, cosmetic or food field b) an aqueous phase c) a lipid phase, and d) emulsifying agents, wherein: * said aqueous phase comprises a base; * the emulsifying agents d) consist of d1) ascorbyl palmitate, d2) one or more polyoxyethylene sorbitan esters and optionally d3) glycocropeptide; * said one or more polyoxyethylene sorbitan esters are comprised in said lipid phase c) * said ascorbyl palmitate is comprised in said aqueous phase or in said lipid phase or in both of said phases, * said active ingredient a) is selected from melatonin and fat soluble vitamins
Role of food's protein on skin health [Ruolo delle proteine alimentari sulla salute della pelle]
No full textOver the past few decades there has been a growing interest among researchers in the influence of diet on skin health. The conclusions of the studies about the contributory role of food on the development of acne are often contradictory. In the course of years the general opinion among researchers has oscillated between two different, opposite position: food is a key factor for acne development or, on the contrary, food isn’t involved. This review examines the role of various foods on the development of acne particularly focusing on carbohydrates. From that prospective we’ve analyzed the physiological and biochemical bases of the ketogenic diet. Finally we suggest the theoretical mechanisms through which this kind of nutritional approach could find a role in acne treatment
Trattato italiano di nutraceutica clinica
No full textIl primo Trattato Italiano di Nutraceutica Clinica, un progetto della Società Italiana di Nutraceutica Clinica (SINut) e di Edizioni Scripta Manent, è uno strumento di formazione ed aggiornamento professionale non solo per i super-specialisti della nutraceutica, ma in generale per tutti i professionisti di area sanitaria interessati a nutrizione, alimentazione funzionale ed integrazione alimentare, come Medici di Medicina Generale e Specialisti, Farmacisti, Biologi nutrizionisti, Laureati in Scienze dietistiche ed in Scienze erboristiche, Tecnologi alimentari.
Il Trattato è rivolto a tutti coloro che vogliono trovare spunti per approfondimenti, puntualizzazioni e confronti sui vari temi affrontati.
Discipline trattate: gastroenterologia, metabolismo ed endocrinologia, malattie cardiache e
cardiovascolari, epatologia, flebologia, geriatria, disturbi dell’umore, insonnia, sistema nervoso centrale e periferico, urologia, immunologia e flogosi, ginecologia, disturbi di ossa ed articolazioni, otorinolaringoiatria, oculistica, medicina dello sport, dermatologia, cosmeceutica
Novel micellar system for Vitamin D3 oral delivery: Assessment of enteric absorption through a digestion-like in vitro model
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