13,342 research outputs found
More on Fustat Fused Rod Beads
No full textMore on Fustat Fused Rod Beads, by Peter Francis, Jr. (1993, 23:3-4
Rod-Like Nanostructured Cu–Co Spinel with Rich Oxygen Vacancies for Efficient Electrocatalytic Dechlorination
No full textDichloromethane (CH2Cl2) hydrodechlorination
to methane (CH4) is a promising approach to remove the
halogenated contaminants and generate clean energy. In this work,
rod-like nanostructured CuCo2O4 spinels with
rich oxygen vacancies are designed for highly efficient electrochemical
reduction dechlorination of dichloromethane. Microscopy characterizations
revealed that the special rod-like nanostructure and rich oxygen vacancies
can efficiently enhance surface area, electronic/ionic transport,
and expose more active sites. The experimental tests demonstrated
that CuCo2O4-3 with rod-like nanostructures
outperformed other morphology of CuCo2O4 spinel
nanostructures in catalytic activity and product selectivity. The
highest methane production of 148.84 μmol in 4 h with a Faradaic
efficiency of 21.61% at −2.94 V (vs SCE) is shown. Furthermore,
the density function theory proved oxygen vacancies significantly
decreased the energy barrier to promote the catalyst in the reaction
and Ov-Cu was the main active site in dichloromethane hydrodechlorination.
This work explores a promising way to synthesize the highly efficient
electrocatalysts, which may be an effective catalyst for dichloromethane
hydrodechlorination to methane
Interview with Rod Ruth - OH 778
No full textThis interview was conducted by Kenya L. Lane with Rod Ruth as part of Project 2020: A Collaborative Oral History. Clover High School Principal Rod Ruth shares his experiences leading one of the state’s largest public schools amid the year 2020’s alarming rise in racial injustice. He discusses in detail the response of his school and school district to students and parents’ concerns regarding racism, especially in light of the unjust deaths of several African Americans across the nation that year. Ruth also talks about his efforts to understand the problems that African Americans students face. In doing so, he recounts participating in a march against racial injustice led by the members of the Roosevelt Community in Clover, SC. Notable topics of conversation include race, racism, diversity, education, leadership, Clover High School, and the Clover School District (CSD).
Rod Ruth served as the Principal of Clover High School from 2015 to 2023; he previously taught social studies education and served in several administrative capacities including as Assistant Principal of Oakridge Middle School (2012-14). In 2023, Ruth took on a new role as the CSD Chief Student Services and Secondary Education Officer. The same year, he was named the South Carolina Secondary Principal of the Year by the SCASA. Ruth holds a B.S. degree from Francis Marion University, a M.Ed. degree from USC-Columbia, and an Educational Specialist degree from Winthrop University.
Spearheaded by Dr. O. Jennifer Dixon-McKnight, an Assistant Professor of History & African American Studies at Winthrop University, Project 2020 is best summarized in her words: “The goal was to conduct interviews that explored the various ways in which Americans were experiencing and being impacted by the various watershed moments that emerged during 2020 (the global pandemic, social unrest, financial challenges, issues with healthcare, etc.).”https://digitalcommons.winthrop.edu/oralhistoryprogram/1694/thumbnail.jp
Rod-Scale Design Strategies for Immune-Targeted Delivery System toward Cancer Immunotherapy
No full textStrengthening
the antitumor immune response to surpass the activation
energy barrier associated with the immunosuppressive tumor microenvironment
is an active area of cancer immunotherapy. Emerging evidence suggests
that delivery of immunostimulatory molecules with the aid of a carrier
system is essential for cancer immunotherapy. However, the size-dependent
effect of the delivery system on immune-targeted sites and anticancer
immune responses is yet to be comprehensively understood. Herein,
to clarify the size-dependent effect of the delivery system on the
underlying anticancer immune mechanism, rod-shaped hydroxyapatite
(HA) particles with lengths from 100 nm to 10 μm are designed.
HA rods stimulate anticancer immunity in a size-dependent manner.
Shorter HA rods with lengths ranging from 100 to 500 nm promote antigen
cellular uptake, dendritic cell (DC) maturation, and lymph node targeting
antigen. In contrast, longer HA rods with lengths ranging from 500
nm to 10 μm prolong antigen retention and increase DC accumulation.
Medium-sized HA rods with a length of 500 nm, taking advantage of
both short and long rods, show optimized antigen release and uptake,
increased DCs accumulation and maturation, highest CD4+ and CD8+ T cell population, and the best anticancer immunity in vivo. The present study provides a rod-scale design strategy
for an immune-targeted delivery system toward cancer immunotherapy
in the future
ROD-1 is required for KNL-1, BUB-1 and CLS-2 to localize to sub-cortical patches.
No full text(A) Maximum intensity projections (MIPs) of the five surface-most focal planes, merged with 5 internal focal planes that include most of the chromosomes, in live control (upper row) or rod-1(RNAi) (lower row) ex utero oocytes expressing mCherry::H2B to mark chromosomes (magenta) and a GFP fusion to ROD-1, CLS-2, BUB-1 or KNL-1 (cyan). (B) Selected and merged focal planes from ex utero oocytes during meiosis I anaphase B that express GFP::PH (cyan) and mCherry::H2B (magenta) to mark the plasma membrane and chromosomes, respectively. A single central focal plane is shown for the membrane, merged with a maximum intensity projection of 5 consecutive internal focal planes that encompass most of the oocyte chromosomes. (C) Quantification of the mean length of membrane ingressions that were 1μm or more in length, the mean sum of lengths, and the mean number of membrane ingressions, over normalized anaphase B time in control and rod-1(RNAi) oocytes. The mean length and mean sum of lengths, but not the number, of ingressions were significantly increased in rod-1 mutant oocytes. (D) Quantification of threshold-limited sub-cortical patch intensities in control and rod-1(RNAi) oocytes expressing GFP fused to ROD-1 and mCherry::H2B, after manually removing spindle associated signal, showing scatter plots for raw integrated pixel intensities and bar graphs for per cent depletion. (PDF)</p
Rod-Shaped Micelles Based on PHF‑<i>g</i>‑(PCL-PEG) with pH-Triggered Doxorubicin Release and Enhanced Cellular Uptake
No full textA biodegradable
brush-type copolymer PHF-g-(PCL-PEG)
based on a cleavable polyacetal backbone and biodegradable side chain
modified with polyethylene glycol (PEG) was synthesized in this paper.
This particular structure was directional to facilitate the formation
of spherical or rod-shaped micelles. Flow cytometry showed that rod-shaped
micelles displayed enhanced cellular uptake compared to spherical
micelles. Rod-shaped micelles were selected to investigate their drug
delivery abilities in detail. In vitro experiments
verified the pH-triggered drug release of DOX-loaded micelles, and
the release rate of doxorubicin (DOX) was 77% at pH 5.0 and 26% at
pH 7.4. In drug-release kinetic analysis, a double-exponential model
achieved the best fit. The copolymer appeared to be almost nontoxic,
while the DOX-loaded micelles showed equivalent cytotoxicity compared
to DOX at high concentration. The endocytosis of DOX-loaded micelles
was two times that of DOX. Our findings suggest that the pH-sensitive
brush type copolymer could be a possible carrier in drug delivery
Mutations in CNNM4 Cause Recessive Cone-Rod Dystrophy with Amelogenesis Imperfecta
No full textCone-rod dystrophies are inherited dystrophies of the retina characterized by the accumulation of deposits mainly localized to the cone-rich macular region of the eye. Dystrophy can be limited to the retina or be part of a syndrome. Unlike nonsyndromic cone-rod dystrophies, syndromic cone-rod dystrophies are genetically heterogeneous with mutations in genes encoding structural, cell-adhesion, and transporter proteins. Using a genome-wide single-nucleotide polymorphism (SNP) haplotype analysis to fine map the locus and a gene-candidate approach, we identified homozygous mutations in the ancient conserved domain protein 4 gene (CNNM4) that either generate a truncated protein or occur in highly conserved regions of the protein. Given that CNNM4 is implicated in metal ion transport, cone-rod dystrophy and amelogenesis imperfecta may originate from abnormal ion homeostasis
Rod-Shaped β‑FeOOH Synthesis for Hydrogen Production under Light Irradiation
No full textRenewable energy
is spotlighted as a resource to replace fossil
fuels, and among the resources, active research on hydrogen energy
is ongoing. Various methods have been developed to produce hydrogen
energy using photoreduction processes. In this study, we synthesized
β-phase iron oxyhydroxide (β-FeOOH) using a hydrothermal
method with an optimal synthesis time and investigated its photofunctional
properties, including hydrogen production. The obtained samples were
characterized and compared with reference data. X-ray powder diffraction
results corresponded to the peaks of the reference data. A rod structure
was confirmed by scanning electron microscopy, and no impurities were
observed. The band-gap energy of β-FeOOH was calculated as 1.8–2.6
eV. A photoreduction process was performed based on a photo-Fenton
reaction to produce hydrogen by irradiating ultraviolet (UV) on β-FeOOH.
The synthesized β-FeOOH was subjected to UV irradiation for
24 h to produce hydrogen, and we confirmed that hydrogen was successfully
produced. The properties of β-FeOOH were evaluated after UV
irradiation
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