28,218 research outputs found
'Beyond, both the Old World, and the New': Authority and Knowledge in the works of Francis Bacon, with special reference to the New Atlantis
No full textPhDThis study investigates the role of authority in the works of Francis Bacon,
arguing that the issue of authority provides not only an interpretation of New
Atlantis, but an important structural component of his body of works. From
the first manifestation of his philosophical project to his last works of natural
history, authority is an all-pervasive issue - the authority of nature, of
scripture, of the named author, and how authority functions in the
dissemination of natural knowledge. Chapter one argues that the publication
of New Atlantis alongside Sylva sylvarum in 1626/7 was more the result of
William Rawley's need to assert his own authority as the protector and
disseminator of Bacon's textual legacy than an appreciation of the work's own
qualities. Chapter two considers Bacon's views of history and time,
suggesting that Bacon not only conceived of a new, progressive mode of
historical time which would allow for the assertion of a textual authority based
on the records of a civilisation unbroken by the vicissitudes of time, but that
he figured these theories in New Atlantis. Chapter three argues that Bacon
used theology both as defence and imperative to his intellectual programme,
while his attempt to move beyond the deterministic, Calvinist world-view to
allow for multiple possible futures, or `chance': Bacon could then present
experiment as the way of eliminating chance, in order to accelerate the rate of
new discovery. Chapter four investigates Bacon's manipulations of textual
authority, from the early rehearsals of the Instauratio magna to the
performance of reliability in print in Sylva sylvarum. Finally, the afterword
seeks to suggest that the New Atlantis hinges on the issues of authority with
which Bacon engaged throughout his career and writings: in the issue of
authority, Francis Bacon found the beginning and the end of his philosophy
CUHK electronic theses & dissertations collection
No full textby Francis Ka-leung Chan.Thesis (M.D.)--Chinese University of Hong Kong, 1997.Includes bibliographical references (p. 187-210).Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.Mode of access: World Wide Web
Ka-band Phase Shifter for Tri-band (L-, Ku-, Ka-bands) Soil Moisture Smart Antenna Array
No full textSoil moisture is a critical parameter in agriculture and weather forecasting, requiring continuous monitoring. Remote sensing radiometers offer a valuable tool for mapping soil moisture over large areas and developing comprehensive climate models when combined with other environmental measurements. Integrating multiple frequency bands, including L-band, Ku-band, and Ka-band, within a single system has the potential to provide high spatial resolution and deep penetration. The primary objective of this thesis is to design Ka-band phase shifters and integrate them into a Ka-band antenna array, creating a cost-effective and planar smart antenna array for soil moisture remote sensing applications
Book review: Francisco Fuster, Aire de familia: Historia íntima de los Baroja. Madrid: Cátedra. 2018
No full textThis is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this recor
Ka-Ks calculation of each pair of syntenic Capsicum ABC paralogs.
No full textKa-Ks calculation of each pair of syntenic Capsicum ABC paralogs.</p
Religious pathways to coping with personal death anxiety among older adult British Christians and Chinese Buddhists: afterlife beliefs, psychosocial maturity and regret management
No full textReligion was proposed to account for the relatively low personal death anxiety found among older adults. This dissertation sought to examine the influence of religious afterlife beliefs, religiously enhanced psychosocial maturity and religious management of a past major regret on personal death anxiety in later life. Terror Management Theory and Erikson’s Psychosocial Theory were used to describe these three religious pathways to coping with personal death anxiety in later life. The cross-sectional postal survey samples consisted of 143 older adult British Christians and 141 older adult Chinese Buddhists. Structural Equation Modelling results from the British Christian survey study showed that intrinsic religiosity predicted lower personal death anxiety through: (a) fostering more benign afterlife beliefs; (b) enhancing psychosocial maturity; and (c) promoting emotional stability. No significant relationship between belief in reincarnation and personal death anxiety was found in the Chinese Buddhist survey study. Both survey studies failed to support the personal death anxiety buffering power of religious management of a past major life regret, although some religious coping strategies were associated with lower negative emotional appraisal towards the major life regret among older adults. The British survey study has been the first to demonstrate both the personal death anxiety buffering and psychosocial maturity enhancing power of religion in an increasingly secular society. The lack of relationship between Buddhist reincarnation beliefs and personal death anxiety suggests that not all religious afterlife beliefs have death anxiety buffering power as proposed by Terror Management Theory. The development of Buddhist reincarnation belief and Buddhist coping scales is a pioneering step towards developing research on under-explored Eastern non-theistic afterlife beliefs and coping measures. Implications for ways that help religious older adults cope with their personal death anxiety were discussed. Prospective cross cultural and cross-religion studies were recommended to replicate the present survey findings. Finally, self detachment (self negation) was proposed as the basis of an alternative death transcendence theory to be researched in future studies on personal death anxiety
KA-11, a Novel Pyrrolidine-2,5-dione Derived Broad-Spectrum Anticonvulsant: Its Antiepileptogenic, Antinociceptive Properties and in Vitro Characterization
No full textRecently,
compound KA-11 was identified as a promising candidate
for a new broad-spectrum anticonvulsant. This compound revealed wide
protective activity across the most important animal models of seizures
such as the maximal electroshock test (MES), the subcutaneous pentylenetetrazole
test (scPTZ), and the six-hertz test (6 Hz, 32 mA).
Importantly, KA-11 was devoid of acute neurological activity, which
was assessed by applying the chimney test (TD50 value higher
than 1500 mg/kg). The preliminary in vivo results confirmed favorable
anticonvulsant and safety properties of KA-11. With the aim of further
biological characterization of KA-11, in the current studies we evaluated
its antiepileptogenic activity in the kindling model of epilepsy induced
by repeated injection of PTZ in mice. Furthermore, we assessed the
antinociceptive activity of KA-11 in several animal pain models. As
a result, KA-11 (at all doses applied: 25, 50, and 100 mg/kg) significantly
delayed the progression of kindling induced by repeated injection
of PTZ in mice. Additionally, KA-11 revealed potent antinociceptive
activity in the formalin-induced tonic pain and, importantly, in the
oxaliplatin-induced neuropathic pain model in mice. Moreover, KA-11
did not induce motor deficits in the rotarod test. Patch-clamp experiments
revealed that one of the mechanisms of action of KA-11 is inhibition
of voltage-gated sodium currents. Compound KA-11 appeared to be safe in relation to hepatotoxic
properties as no phospholipidosis induction was determined in HepG2
cells at 50 μM, and a small, statistically significant decrease
of cell viability was observed only at the highest used dose of 100
μM. Moreover, KA-11 did not affect the function of CYP2D6. The
aforementioned hybrid substance proved to penetrate the biological
membranes in the in vitro permeability assays
Guadeloupe’s Ka-ribbean Bodies in Conflict: Gerty Dambury and Gisèle Pineau" Critical Perspectives on Conflict in Caribbean Societies of the Late 20th and Early 21st Centuries
No full textOriginally published in:
Francis, Gladys M. "Guadeloupe’s Ka-ribbean Bodies in Conflict: Gerty Dambury and Gisèle Pineau" Critical Perspectives on Conflict in Caribbean Societies of the Late 20th and Early 21st Centuries. Ed. R. Sobiac & P. Donatien-Yssa. Newcastle: Cambridge Scholars Press (2015): 65-82.
(c) Cambridge Scholars Press. Published with the permission of Cambridge Scholars Publishing
KA-injected rats display deficits in gross hindlimb function after two weeks.
No full textA score below 9 indicates that animals do not have full weight-supported steps but a score above 14 indicates consistent coordination while walking. (A-B) KA-injected animals have a significantly lower BBB score and sub-score after two weeks in comparison to the control (BBB score: 2-way ANOVA with Sidak’s post hoc test, group p 2 = 0.7913; BBB sub-score p 2 = 0.7957). For all data, n = 7 animals per group; * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001.</p
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