704 research outputs found
Rethinking Demonic Possession: The impact of the debates about the John Darrel case on later demonological thought, with particular reference to John Deacon and John Walker
No full textThe controversy that led to the conviction of the Puritan exorcist John
Darrel for fraud in 1599 has mainly been viewed by historians in the context of
the struggle between Puritans and the Church of England. Darrel’s activities
have been seen as Puritan propaganda, whilst the authorities’ reaction has been
seen as part of their campaign against Puritanism. Their clamp down on
Darrel’s activities has also been seen as contributing towards increasing
scepticism towards demonic possession in early modern England, especially in
cases involving witchcraft.
This thesis argues that the Darrel controversy cannot be read solely as a
manifestation of the Puritan/establishment conflict, as it will demonstrate how
the controversy was actually part of the broader re-assessment of the role of the
supernatural in the contemporary world following the Reformation, and that
anti-Catholicism, in particular hostility towards the Catholic rite of exorcism,
played a significant role in informing sceptical attitudes towards demonic
possession.
Focussing upon the work of the Puritan preachers John Deacon and John
Walker, it will also challenge the Puritan/establishment dichotomy over
possession. Their work denied the possibility of possession in their own time by
drawing on and elaborating existing medical, natural philosophical and
theological arguments, particularly the doctrine of the cessation of miracles.
Their work was significant because it was the first work that systematically
explored the intricacies of the phenomenon of possession, and it offered an
alternative way of thinking about demonic affliction, namely the category of
obsession. Writings that appeared following the Darrel controversy demonstrate
an awareness of Deacon and Walker’s arguments, and also reveal how the idea
of obsession was absorbed into broader demonological thought, thus
highlighting how Deacon and Walker’s work was much more significant than
has previously been thought
PSX848901_Supplemental_material – Supplemental material for Education, Family Background, and Political Knowledge: A Test of the Compensation Hypothesis with Identical Twins
No full textSupplemental material, PSX848901_Supplemental_material for Education, Family Background, and Political Knowledge: A Test of the Compensation Hypothesis with Identical Twins by Darrel Robinson in Political Studies</p
Francis Bacon's science of magic
Get PDFThis thesis seeks to explain how Francis Bacon promoted a materialist ontology whilst at the same time designating the goal of his inquiry into nature "true natural magic. " It attempts to establish the precise relationships among Bacon's concepts of matter, inquiry and magic in terms of his novel conception of nature. Baconian matter forms the basis of Bacon's substantive natural philosophy; it is highly potent and the unique source of operative power. In its unhampered or "free" state, nature takes the easiest and most economic route leaving a reservoir of unused possibility. To access the benefits of this unexploited potential, the Baconian mage experimentally and methodically deflects nature from its habitual course. Thus
Baconian operational power is derived from constraining or binding nature so as to activate matter's dormant powers. For Bacon, magic is the artful constraint of nature. Through harnessing the primitive and archetypal powers of matter, Baconian magic would achieve what the magical and alchemical traditions had attempted haphazardly. Magic constitutes the capstone of Bacon's reform of natural
philosophy and it relies fundamentally on a plenipotentiary matter. The inquiry prepares and guides the mind in its efforts to achieve that goal. Although these themes are often fragmented by commentators, they form a coherent natural philosophical foundation for Bacon's Instauratio magna. Their reintegration requires a return to Bacon's texts. A close reading of Bacon's works demonstrates a
complex but internally coherent substantive philosophy. By placing Bacon's materialism centre-stage, in conjunction with thorough and detailed exegesis, longstanding
disputes over central Baconian concepts can be resolved
sj-pdf-1-psx-10.1177_00323217211067385 – Supplemental material for Educating Democrats or Autocrats? The Regime-Conditional Effect of Education on Support for Democracy
No full textSupplemental material, sj-pdf-1-psx-10.1177_00323217211067385 for Educating Democrats or Autocrats? The Regime-Conditional Effect of Education on Support for Democracy by Marcus Österman and Darrel Robinson in Political Studies</p
Haemodynamic optimization of cardiac resynchronization therapy
Get PDFHeart failure carries a very poor prognosis, unless treated with the appropriate pharmacological agents which, have been evaluated in large randomized clinical trials and have demonstrated improvements in morbidity and mortality of this cohort of patients. A significant proportion of these patients develop conduction abnormalities involving both the atrioventricular node and also the specialised conduction tissue (bundle of His and Purkinje fibers) of the ventricular myocardium which is most commonly evidenced by the presence of a wide QRS, typically left bundle branch block. The net effect of these conduction abnormalities is inefficient filling and contraction of the left ventricle. The presence of these conduction abnormalities is an additional strong marker of poor prognosis. Over the last 15 years pacing treatments have been developed aimed at mitigating the conduction disease. Large scale randomized multicentre trials have repeatedly demonstrated the effectiveness of cardiac pacing, officially recognized as cardiac resynchronization therapy (CRT). This mode of pacing therapy has undoubtedly had a positive impact on both the morbidity and mortality of these patients.
Despite the large advancement in the management of heart failure patients by pacing therapies, a significant proportion of patients (30%) being offered CRT are classed as non-responders. Many explanations have been put forward for the lack of response. The presence of scar at the pacing site with failure to capture or delayed capture of myocardium, too much left ventricular scar therefore minimal contractile response, incorrect pacing site due to often limited anatomical options of lead placement and insufficient programming i.e optimization, of pacemaker settings such as the AV and VV delay are just some of the suggested areas perceived to be responsible for the lack of patients’ response to cardiac resynchronization therapy.
The effect of optimization of pacemaker settings is a field that has been investigated extensively in the last decade. Disappointingly, current methods of assessing the effect of optimization of pacemaker settings on several haemodynamic parameters, such as cardiac output and blood pressure, are marred with very poor reproducibility, so measurement of any effect of optimization is close to being meaningless.
Moreover, detailed understanding of the effects of CRT on coronary physiology and cardiac mechanoenergetics is equally, disappointingly, lacking.
In this thesis, I investigated the acute effects of cardiac resynchronization therapy and AV optimization on coronary physiology and cardiac mechanoenergetics. This was accomplished using very detailed and demanding series of invasive catheterization studies. I used novel analytical mathematical techniques, such as wave intensity analysis, which have been developed locally and this provided a unique insight of the important physiological entities defining coronary physiology and cardiac mechanics.
I explored in detail the application and reliability of photoplethysmography as a tool for non-invasive optimization of the AV delay. Photoplethysmography has the potential of miniaturization and therefore implantation alongside pacemaker devices.
I compared current optimization techniques (Echocardiography and ECG) of VV delay against beat-to-beat blood pressure using the Finometer device and defined the criteria that a technique requires if such a technique can be used meaningfully for the optimization of pacemaker settings both in clinical practice and in clinical trials.
Finally, I investigated the impact of atrial pacing and heart rate on the optimal AV delay and attempted to characterize the mechanisms underlying any changes of the optimal AV delay under these varying patient and pacing states.
In this thesis I found that optimization of AV delay of cardiac resynchronization therapy not only improved cardiac contraction and external cardiac work, but also cardiac relaxation and coronary blood flow, when compared against LBBB.
I found that most of the increase in coronary blood flow occurred during diastole and that the predominant drive for this was ventricular microcirculatory suction as evidenced by the increased intracoronary diastolic backward-travelling decompression wave.
I showed that non-invasive haemodynamic optimization using the plethysmograph signal of an inexpensive pulse oximeter is as reliable as using the Finometer. Appropriate processing of the oximetric signal improved the reproducibility of the optimal AV delay. The advantage of this technology is that it might be miniaturized and implanted to provide automated optimization.
In this thesis I found that other commonly used modalities of VV optimization such as echocardiography and ECG lack internal validity as opposed to non-invasive haemodynamic optimization using blood pressure. This finding will encourage avoidance of internally invalid modalities, which may cause more harm than good.
In this thesis I found that the sensed and paced optimal AV delays have, on average, a bigger difference than the one assumed by the device manufacturers and clinicians. As a significant proportion of patients will be atrially paced, especially during exercise, optimization during this mode of pacing is equally crucial as it is during atrial sensing.
Finally, I found that the optimal AV delay decreases with increasing heart rate, and the slope of this is within the range of existing pacemaker algorithms used for rate adaptation of AV delay, strengthening the argument for the rate adaptation to be programmed on.Imperial Users Onl
Supplemental Material, AJE824417_Supplemental_Appendix_A - Enhancing the Effectiveness of Logic Models
No full textSupplemental Material, AJE824417_Supplemental_Appendix_A for Enhancing the Effectiveness of Logic Models by Natalie D. Jones, Tarek Azzam, Dana Linnell Wanzer, Darrel Skousen, Ciara Knight and Nina Sabarre in American Journal of Evaluation</p
sj-docx-1-tah-10.1177_20406207221085202 – Supplemental material for International consensus recommendations on the management of people with haemophilia B
No full textSupplemental material, sj-docx-1-tah-10.1177_20406207221085202 for International consensus recommendations on the management of people with haemophilia B by Daniel P. Hart, Davide Matino, Jan Astermark, Gerard Dolan, Roseline d’Oiron, Cédric Hermans, Victor Jiménez-Yuste, Adriana Linares, Tadashi Matsushita, Simon McRae, Margareth C. Ozelo, Sean Platton, Darrel Stafford, Robert F. Sidonio and Andreas Tiede in Therapeutic Advances in Hematology</p
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