1,721,018 research outputs found

    INTERDIGITATING RETICULUM CELL AND LYMPHOPROLIFERATIVE DISEASE:POSSIBLE CORRELATIONS BETWEEN SKIN AND THYMUS-DEPENDENT LYMPHOCYTE SYSTEM REVISITED

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    Three cases of primary cutaneous T-cell lymphoma non-Sézary and non-mycosis fungoides are described, in which ultrastructural investigations revealed the presence of interdigitating reticulum cell in the skin infiltrate. The cytological finding is discussed in light of the immunological function hypothetically performed by the skin

    Darbepoetin in the control of cancer-related anaemia

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    A group of 62 patients with different advanced cancers and with an anaemic condition were treated with a short course of darbepoetin administered on two different schedules as supportive therapy. The response rates (i.e. a haemoglobin increase of at least 1 g in 1 month) were 45.7% overall, 52.3% with weekly administration and 39% with 3-weekly administration. Darbepoetin activity was higher in men than in women, in younger patients than in older patients and in moderately anaemic patients than in severely anaemic patients, but these differences were not significant. Darbepoetin administration appears to be useful in rapidly reversing anaemia related to advanced cancer. However, the results reported in the literature for alpha-erythropoietin remain more appealing
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