1,721,479 research outputs found
Long-term results of a randomized trial comparing Cisplatin with Cisplatin and Cyclophosphamide with Cisplatin, Cyclophosphamide, and Adriamycin in advanced ovarian cancer.
No full textWe report the long-term results of a randomized trial comparing cisplatin (P) with cisplatin and cyclophosphamide (CP) with cisplatin, cyclophosphamide, and adriamycin (CAP) in advanced ovarian cancer. Overall, this update confirms previously published data on 529 cases. Median survival times for the three treatments--CAP, CP, and P--are, respectively, 23, 20, and 19 months. The differences among the three arms are still nonsignificant and the estimated percentage survival at 7 years and confidence limits are, respectively, 21.7 (14.9-28.4), 17.0 (11.0-22.9), and 12.2 (6.9-17.4). According to the results of the Cox regression model on prognostic factors, higher grading, a larger residual tumor size, and performance status less than 80 (Karnovsky) all were independently associated with a poorer outcome, while a serous histotype was related to a better prognosis. The other variables (age, stage, center, type of surgery) initially included in the model did not appear to be significantly related to prognosis. The implications of these long-terms results relative to the application of combination chemotherapy with CAP or CP are discussed
Requisiti Minimi per il Trattamento delle Neoplasie Ginecologiche. Società Italiana di Oncologia Ginecologica.
No full textL'evoluzione della modulazione della radicalità continuamnete proposta sia per la stadiazione che per l'adeguata exeresi primaria si è arricchita di tecniche di dissezione sempre più accurate e rispettose dei visceri contigui dell'apparato genitale. Questo autorevole contributo della SIOG, oltre a delineare i "requisiti minimi" per il trattamento delle neoplasie ginecologiche, enuncia lo stato dell'arte dell'oncologia ginecologica e sottolinea cultura e professionalità indispensabili per chi aspira ad esserne protagonista
Adenocarcinoma of uterine cervix. A clinicopathological Study.
No full textAdenocarcinoma of uterine cervix. A clinicopathological Study
Estrogeni e metabolismo osseo.
No full textThe authors present a review referring to cellular and biochemical control systems of bone remodeling as well as the effect of estrogens on modulation of bone metabolism. Systemic and local control factors such as PTH, calcitonin, vitamin D, prostaglandins, insulin-like growth factor-1, transforming growth factor-beta are analyzed as possible indirect targets for the estrogen induced inhibition of bone resorption. A direct receptor-linked action of estrogens on the osteoblast-lining cell unit, the most important modulator or bone metabolism, is furtherwise examined. The precise mechanism of the beneficial effect of estrogens for the prevention of postmenopausal bone loss and the treatment of established osteoporosis has not yet been clearly identified, but it seems likely that multiple mechanisms may be involved since postmenopausal osteoporosis itself appears as a heterogenic clinical condition related to multiple pathogenetic factor
Prolactin levels, after MPA employment, in women affected with endometrial adenocarcinoma.
No full textProlactin levels, after MPA employment, in women affected with endometrial adenocarcinoma
Immunodiagnosis in gynaecologic oncology: possibilities and limitations.
No full textThe theory of Immunological Surveillance suggested by Burnet has been the object of many criticisms over the last years, but the study and the clinical applications of tumours immunology still show a remarkable interest with attracting prospects for the future. Some markers for human tumours cells, detected by RIA assay (TA4 for cervical cancer, CEA for ovarian cancer and alpha-FP for Endodermal Sinus Tumour) allow accuracy in neoplastic patients. The study of the tumoural patient's immunologic status could point out diagnostic and prognostic criteria and is likely to be used in the future for screening groups at risk for developing neoplasia
Le infezioni in chirurgia ostetrico-ginecologica: chemioantibioticoprofilassi e terapia.
No full textThe Authors review, on the basis of their experience, the literature data concerning chemo-antibiotic prophylaxis in gynaecological surgery. Prophylaxis is widely employed although some important aspects are still under evaluation: bacterial selection and resistance, benefit in case of abdominal hysterectomy or elective Cesarean section, risk of pseudomembranous colitis. The most effective drugs are Piperacillin/Mezlocillin given in a single dose preoperatively. The same drugs are useful in the treatment of postsurgical infections
Le recidive del cervicocarcinoma ( rassegna bibliografica ).
No full text[Recurrence of cervical carcinoma (bibliographic review)]
Cinetica proliferativa delle neoplasie dell’ovaio: studio mediante incorporazione in vivo di bromodesossiuridina e citoflurometria a flusso.
No full textCinetica proliferativa delle neoplasie dell’ovaio: studio mediante incorporazione in vivo di bromodesossiuridina e citoflurometria a flusso
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