45 research outputs found
La riforma dell’ente di area vasta fra criticità costituzionali e difficoltà attuative
No full textIl lavoro, partendo dall'esame dei principali dubbi di costituzionalità sollevati in ordine alla cd. Legge Delrio, la n.56/2014, propone una lettura critica della sentenza n.50/2015, con cui la Corte costituzionale ha rigettato i ricorsi proposti avverso la suddetta legge dalle Regioni Campania, Puglia e Veneto
Regina Viarum heritage UNESCO, the new frontier of slow and sustainable tourism between East and West
No full textThe aim of this work is to analyze the economic and managerial perspectives of all public and
private entities involved in decision-making, executive and control processes related to the
protection of the new UNESCO site “Via Appia. Regina Viarum”. The survey is based on a
theoretical reflection on the issue of governance and management of Public Value (PV) in the
cultural field. The performance measurement at the level of public administration "groups" and
networks and the consequent evaluation of management results can be carried out following the
theoretical approach of Public Value Governance (PVG), which takes account of the exchange
systems and relational capital built by the network actors. The conceptual framework for the
PVG model analysis considers the co-creation of public value as the final performance outcome
at the level of inter-institutional supply chain. The problem of measuring supply chain PV is
placed within the context of describing the dynamics of programming, creation and evaluation
of the performance cycle within “mixed” type inter-institutional chains, composed of a
multitude of actors (public and private organizations, citizens/users) who cooperate to add
value. The method adopted is based on the analysis of the management plan drawn up by the
UNESCO Committee, which assumes a programmatic and strategic function in the
development of the area in which the cultural asset is inserted, with a focus on the recomposition
of the operational objectives linked to the numerous action plans and interventions in the
cultural and tourism sectors. The formalization of a model for monitoring the variables
affecting the Public Value creation in public-private networks is an immediate research
objective able to integrate the theoretical framework of a collaborative and participative PV
generation model in the cultural tourism management setting
Expression of 3-nitrotyrosine, a marker for peroxynitrite, in nasal polyps of nonatopic patients.
No full textBACKGROUND:
Several works have reported that nitric oxide and free oxygen radicals are up-regulated in nasal polyposis. This study aimed to assess the distribution of peroxynitrite in nasal polyps from nonatopic patients. Occurrence of peroxynitrite also was analyzed in relation with eosinophil infiltration and epithelial alterations.
MATERIAL/METHODS:
Hematoxylin and eosin staining was used for histologic study. Peroxynitrite was assessed by 3-nitrotyrosine immunohistochemistry. Quantitative evaluation was done by measuring the total number of eosinophils, the number of 3-nitrotyrosine-positive eosinophils, and the extension of the various epithelial alterations.
RESULTS:
Hematoxylin and eosin staining showed that the nasal polyp epithelium is characterized by progressive disruption or squamous metaplasia. In both cases, infiltrating eosinophils were found in the epithelium and lamina propria. The regions featuring epithelial disruption exhibited 3-nitrotyrosine immunostaining in eosinophils and epithelial cells; hematoxylin-and-eosin - stained eosinophils and 3-nitrotyrosine - positive eosinophils showed conspicuous variations in number. Within the regions featuring squamous metaplasia, 3-nitrotyrosine-positive eosinophils were rarely found, and the epithelium exhibited 3-nitrotyrosine only in the superficial cells. In these regions, hematoxylin-eosin - stained eosinophils showed slight variations in number.
CONCLUSIONS:
Peroxynitrite plays a pivotal role in the pathophysiology of nasal polyps. In fact, strong expression of peroxynitrite is associated with epithelial disruption, while poor expression of peroxynitrite is associated with squamous metaplasia. Peroxynitrite could influence afflux of eosinophils in the nasal mucosa; moreover, the total number of eosinophils is not critical in generating alterations of nasal polyp mucosa
Ionic‐Liquid‐Assisted Metal‐Free Oxidative Coupling of Amines To Give Imines
No full textAn oxidative coupling of amines to give imines in ionic liquids (ILs) under metal-free aerobic conditions has been developed. The high efficiency achievable in ILs is mechanistically explained in terms of activation of the starting materials (benzylamine and molecular oxygen) by an initial electron transfer, promoted by the ionic nature of the solvent. Reactivity data of variously p-substituted benzylamines show a general deactivating effect, which would imply a change in the rate-determining step in the reaction mechanism
Il ruolo dell’ossido nitrico nella mucosa nasale
No full textNitric oxide is a small gaseous molecule produced in many types of mammalian cells, in which it contributes to a variety of physiologic and pathophysiologic processes. The presence in the upper airways of high concentrations of nitric oxide has important effects for the field of otorhinolaryngology. In fact, several pieces of evidences have suggested that in the nasal respiratory mucosa nitric oxide plays significant functions, such as mucociliary clearance, vascular homeostasis, immune defense and cytotoxicity. The immunohistochemical and ultracytochemical studies have provided a number of evidences to know more about the role that nitric oxide plays in the nasal respiratory mucosa, both in healthy subjects and in some pathological conditions. Nevertheless, as several functional roles played by the nitric oxide in the nasal respiratory mucosa remain to be elucidated, further researches are required to understand fully the role of nitric oxide in the upper airways
Copper(II) chloride-catalysed oxidative carbonylation of glycerol to glycerol carbonate
No full textA systematic study on copper(II) as catalyst for the synthesis of glycerol carbonate via oxidative carbonylation
is here reported for the first time. Copper(II) chloride has been found to efficiently promote
the process under homogeneous conditions treating glycerol with CO:O2 (Ptot = 4 MPa; P(O2) = 0.7 MPa),
in DMA at 130 ◦C and in the presence of pyridine as co-catalyst. Excellent conversions (>92%) and selectivities
(>93%) are obtained in relatively short reaction times (3–4 h) also with copper(II) complexes.
The catalyst overall TON is evaluated and new experimental evidences are provided allowing significant
advancements in the mechanism comprehension
Regioselective aerobic oxidation of bis-sulfides into monosulfoxides
No full textThe cobalt(II)acetylacetonate/aldehyde-promoted aerobic oxidation of three bis-sulfides of general formula R1-
SCH2CH2S-R2, where R1 is a heterocycle and R2 is p-tolyl, provides a method to functionalise selectively the sulfur atom
bonded to the p-tolyl moiety leading to the corresponding monosulfoxides. The same chemoselectivity and little
diastereoisomeric excess (10%). was achieved by submitting to oxidative conditions the chiral bis-sulfide (5)-R3-
SCH2CHCH3.CH2-SR4 (R3sbenzothiazolyl, R4sp-tolyl)
The Leading Role of the Immune Microenvironment in Multiple Myeloma: A New Target with a Great Prognostic and Clinical Value
No full textMultiple myeloma (MM) is a plasma cell (PC) malignancy whose development flourishes in the bone marrow microenvironment (BMME). The BMME components’ immunoediting may foster MM progression by favoring initial immunotolerance and subsequent tumor cell escape from immune surveillance. In this dynamic process, immune effector cells are silenced and become progressively anergic, thus contributing to explaining the mechanisms of drug resistance in unresponsive and relapsed MM patients. Besides traditional treatments, several new strategies seek to re-establish the immunological balance in the BMME, especially in already-treated MM patients, by targeting key components of the immunoediting process. Immune checkpoints, such as CXCR4, T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT), PD-1, and CTLA-4, have been identified as common immunotolerance steps for immunotherapy. B-cell maturation antigen (BCMA), expressed on MMPCs, is a target for CAR-T cell therapy, antibody-(Ab) drug conjugates (ADCs), and bispecific mAbs. Approved anti-CD38 (daratumumab, isatuximab), anti-VLA4 (natalizumab), and anti-SLAMF7 (elotuzumab) mAbs interfere with immunoediting pathways. New experimental drugs currently being evaluated (CD137 blockers, MSC-derived microvesicle blockers, CSF-1/CSF-1R system blockers, and Th17/IL-17/IL-17R blockers) or already approved (denosumab and bisphosphonates) may help slow down immune escape and disease progression. Thus, the identification of deregulated mechanisms may identify novel immunotherapeutic approaches to improve MM patients’ outcomes
